Anest. intenziv. Med. 2000;11(5):219-221

Lung Changes as a Possible Result of Adverse Effects of Betalactam AntibioticsArticles

M. Filaun¹, I. Lišková¹, J. Stejskal², V. Mužíková³, O. Lochman⁴, E. Bébrová⁴

¹ Klinika AR 2. LF UK a IPVZ, FN Motol, přednosta doc. MUDr. K. Cvachovec, CSc.

Authors refer to not much known adverse reaction in treatment with betalactam antibiotics. In years 1997 - 1998 there was 691 children treatedin our ICU, we found in 25 of them increased level of antibodies against betalactam antibiotics. Indication for examination of level antibodies wasX-ray picture of wet lung, contemporary application of betalactam antibiotics and somet imes positive allergic history. Antibodies was determined withmethod of non direct hemaglutination and as a positive finding was level 1:320 and more. In these cases was antibiotic treatment changed to antibioticsof other type. We found recess of X-ray picture in 20 cases, 5 children died. Histological inv estigation for evaluation of immunocomplexes C3 and IgGin the wall of alveoli was made immediately post mortem. Immunofluorescent investigation findings were positive in 4 cases. Authors recommend incase of worsening of lung changes to evaluate level of antibodies and replace betalactam antibiotics with antibiotics of other type.

Keywords: betalactam antibiotics; level of antibodies against betalactam antibiotics; adverse effect of antibiotics; immunofluorescent investigation

Published: October 1, 2000  Show citation