Anest. intenziv. Med. 2013;24(1):26-32

Contribution of brain dormancy to clinical signs of brain damage and the possibility of its treatment by zolpidemAnaesthesiology - Review articles

Augustini Lucie1, Gabrhelík Tomáš2,*, Adamus Milan1
1 Rehabilitační oddělení NsP Nový Jičín
2 KARIM FN a LF UP v Olomouci, Olomouc

Most of the various types of brain injuriy are supposed to be connected with neuroprotective supression of brain activity, so-called brain dormancy. The reason for this suppressed neuronal activity is protection of brain tissue from damage. However reduction in neuronal energy metabolism and function makes the clinical symptoms more serious. Later after brain injury inception, brain dormancy and suppression offer no benefit. Currently many experimental advances, pharmacological and non-pharmacological, are being made to achieve brain dormancy switch-off. One of drugs frequently used to restore brain function is zolpidem.

Keywords: brain dormance; brain tissue damage; GABA; zolpidem; vegetative state; treatment of brain injury consequence

Received: October 10, 2012; Accepted: November 13, 2012; Published: February 1, 2013  Show citation

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Augustini L, Gabrhelík T, Adamus M. Contribution of brain dormancy to clinical signs of brain damage and the possibility of its treatment by zolpidem. Anest. intenziv. Med. 2013;24(1):26-32.
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    References

    1. Lippertová-Grünerová, M. Trauma mozku a jeho rehabilitace. 1. vyd. Praha: Galen, 2009, ISBN 978-80-7262-569-7.
    2. Kuschinsky, W. Krevní oběh mozku, hematoencefalická bariéra, mozkomíšní mok. In Folsch, S. et al. Patologická fyziologie. Praha: Grada Publishing, 2003, s. 163-172, ISBN 80-247-0319-X.
    3. Vožeh, F. Mechanismy excitotoxicity. In Hulín, V. et al. Patofyziológia. 7. vyd. Bratislava: FABER, 2009, s. 1119-1122, ISBN 978-80-8095-043-9.
    4. Clauss, R. P., Nel, W. Drug induced arousal from the permanent vegetative state. NeuroRehabilitation, 2006, roč. 21, s. 23-28. Go to original source... Go to PubMed...
    5. Singh, R., McDonald, C., Dawson, K., Lewis, S., Pringle, A. M., Smith, S., Pentland, B. Zolpidem in a minimally conscious state. Brain Injury, 2008, roč. 22, 1, s. 103-106. Go to original source... Go to PubMed...
    6. Giacino, J. T., Hirsch, J., Schiff, N., Laureys, S. Functional neuroimaging applications for assessment and rehabilitation planning in patients with disorders of consciusness. Arch. Phys. Med. Rehabil., 2006, roč. 87, 2, s. 67-76. Go to original source... Go to PubMed...
    7. Clauss, R. P., Güldenpfennig, W. M., Nel, H. W., Sathekge, M. M., Venkannagari, R. R. Extraordinary arousal from semi-comatose state on zolpidem. SAMJ, 2000, roč. 90, s. 68-72.
    8. Clauss, R. P. Evidence for zolpidem efficacy in brain damane. Pharm. Pract., 2005, roč. 47, 3, s. 49-50. Go to original source...
    9. Cohen, L., Chaaban, B., Habert, M. Transient improvement of aphasia with zolpidem. N. Engl. J. Med., 2004, roč. 350, 9, s. 949-950. Go to original source... Go to PubMed...
    10. Shames, J., Ring, H. Transient reversal of anoxic brain injury - related minimally conscious state after zolpidem administration: A case report. Arch. Phys. Med. Rehabil., 2008, roč. 89, 2, s. 386-388. Go to original source... Go to PubMed...
    11. Cohen, S., Duong, T. Increased arousal in a patient with anoxic brain injury after administration of zolpidem. Am. J. Phys. Med. Rehabil., 2008, roč. 87, 3, s. 229-931. Go to original source... Go to PubMed...
    12. Thomas, P., Cottencin, O., Rascle, C., Vaiva, G., Goudemand, M., Bieder, J. Catatonia in French Psychiatry: Implications of the zolpidem challenge test. Psychiatric. Annals, 2007, roč. 37, 1, s. 45-54. Go to original source...
    13. Daniele, A., Albanese, A., Gainotti, G., Gregori, B., Bartolomeo, P. Zolpidem in Parkinson's disease. Lancet, 1997, roč. 349, s. 1222-1223. Go to original source... Go to PubMed...
    14. Chen, Y., Sy, H., Wu, S. Zolpidem improves akinesia, dystonia and dyskinesia in advanced Parkinson's disease. J. Clin. Neurosci., 2008, roč. 15, s. 955-956. Go to original source... Go to PubMed...
    15. Shadan, F., Poceta, J., Kline, L. Zolpidem for postanoxic spasticity. Southern Medical Journal, 2004, roč. 97, 8, s. 791-792. Go to original source... Go to PubMed...
    16. Whyte, J., Myers, R. Incidence of clinically significant responses to zolpidem among patients with disorders of consciousness. Am. J. Phys. Med. Rehabil., 2009, roč. 88, 5, s. 410-418. Go to original source... Go to PubMed...
    17. Lazzaro, V., Pilato, F., Dileone, M., Ranieri, F., Ricci, V., Profice, P., Bria, P., Tonali, P.A., Ziemann, U. GABAA receptor subtype specific enhancement of inhibition in human motor cortex. J. Physiol., 2006, roč. 575, 3, s. 721-726. Go to original source... Go to PubMed...
    18. Brefel-Courbon, C., Payoux, P., Ory, F., Sommet, A., Slaoui, T., Raboyeau, G. et al. Clinical and imaging evidence of zolpidem effect in hypoxic encephalopathy. Annals of Neurology, 2007, roč. 62, 1, s. 102-105. Go to original source... Go to PubMed...
    19. Hall, S., Yamawaki, N., Fisher, A. E., Clauss, R. P., Woodhall, G. L., Stanford, I. M. Desynchronization of pathological low-frequency brain activity by the hypnotic drug zolpidem. Nature Precedings, 2008, roč. 23, s. 6-11. Go to original source...
    20. Nyakale, N. E., Clauss, R. P., Nel, W., Sathekge, M. Clinical and brain SPECT scan response to zolpidem in patients after brain damage. Arzneimittelforschung, 2010, roč. 60, 4, s. 177-181. Go to original source... Go to PubMed...
    21. Clauss, R. P. Neurotransmitters in coma, vegetative and minimally conscious states, pharmacologicals interventions. Medical hypotheses, 2010, roč. 75, 3, s. 287-290. Go to original source... Go to PubMed...
    22. Hall, S., Yamawaki, N., Fisher, A. E., Clauss, R. P., Woodhall, G. L., Stanford, I. M. GABA(A) alpha-1 subunit mediated desynchronization of elevated low frequency oscillations alleviates specific dysfunction in stroke - A case report. Clinical neurofysiology, 2010, roč. 121, 4, s. 549-555. Go to original source... Go to PubMed...
    23. Oliveira, L., Fregni, F. Pharmacological and electrical stimulation in chronic disorders of consciousness: New insights and future directions. Brain Injury, 2011, roč. 25, 4, s. 315-327. Go to original source... Go to PubMed...
    24. ReGen Therapeutics. Pharmaceuticals - Zolpidem. [online]. 2009 Dec; [cit. 2012-4-28]. Dostupné na: www.regentherapeutics.com/rtl/products/zolpidem/

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