Anest. intenziv. Med. 2010;21(3):128-133

Sugammadex (Bridion®) - our first experience with the reversal of moderate rocuronium-induced neuromuscular blockAnaesthesiology - Original Paper

Adamus Milan^1,*, Hrabálek Lumír², Koutná Jiřina¹

¹ Klinika anesteziologie a resuscitace, Fakultní nemocnice a Lékařská fakulta Univerzity Palackého v Olomouci

² Neurochirurgická klinika, Fakultní nemocnice a Lékařská fakulta Univerzity Palackého v Olomouci

Objective:
To study the reversal of moderate rocuronium-induced neuromuscular block as part of balanced general anaesthesia with sugammadex 2 mg/kg.

Design:
Clinical, observational, retrospective, non-interventional study.


Setting:
Department of Anaesthesiology, University Hospital.

Materials and methods:
The reversal of moderate rocuronium-induced neuromuscular block with sugammadex (2 mg/kg) was retrospectively studied. We used TOF stimulation of the ulnar nerve at 15-s intervals and measured the accelerometric response of the adductor pollicis muscle (TOF-Watch® SX). Following spontaneous recovery to TOF-count = 2, sugammadex (2 mg/kg) was administered and the reversal of the block was recorded. We transferred the data (TOF-ratio, T1) via a link to the computer and presented the results using descriptive statistics and graphs.

Results:
We analysed the data from 18 males and 14 females. The mean age was 46 years, mean weight 74 kg, mean height 170 cm and mean BMI 25.84 kg/m2. The mean duration of anaesthesia was 64 minutes. During spontaneous recovery from the block, the reaction to the second impulse in TOF (TOF-count = 2) was detected as early as T1 = 19 %. Median (quartiles) of time to full recovery (TOF-ratio ≥ 0.9) was 97.5 (75; 130) s following sugammadex administration. Full recovery was observed in 13 % patients at 1 minute, in 72 % at 2 minutes and in all the patients at 3 minutes. No adverse effects following sugammadex administration were observed.

Conclusion:
Following sugammadex (2 mg/kg) administration, the reversal of moderate rocuronium-induced block was reliable and full recovery was reached within 3 minutes of sugammadex administration.

Keywords: rocuronium; sugammadex; neuromuscular block; reversal

Published: June 1, 2010  Show citation