Anest. intenziv. Med. 2016;27(3):170-176

Fifty-five year old man with thrombocytopaenia and life threatening diffuse alveolar haemorrhage. Case reportIntesive Care Medicine - Case Report

T. Karvunidis1,*, M. Harazim1, J. Raděj1, P. Salaj2, J. Horák1, I. Novák1, M. Matějovič1
1 Jednotka intenzivní péče, I. interní klinika FN Plzeň a LF v Plzni, Univerzita Karlova v Praze
2 Ústav hematologie a krevní transfuze, Praha

This case report presents a patient with acute respiratory failure due to life-threatening haemoptysis resulting from severe and refractory thrombocytopenia. It presents the diagnostics, differential diagnostics and management of such illness.

Keywords: thrombocytopaenia; haemoptysis; respiratory failure; intensive care

Published: June 1, 2016  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Karvunidis T, Harazim M, Raděj J, Salaj P, Horák J, Novák I, Matějovič M. Fifty-five year old man with thrombocytopaenia and life threatening diffuse alveolar haemorrhage. Case report. Anest. intenziv. Med. 2016;27(3):170-176.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Abrahamson, P. E., Hall, S. A., Feudjo-Tepie, M., Mitrani-Gold, F. S., Logie, J. The incidence of idiopathic thrombocytopenic purpura among adults: a population-based study and literature review. Eur. J. Haematol., 2009, 83, 2, p. 83-89. Go to original source... Go to PubMed...
    2. Terrell, D. R., Beebe, L. A., Vesely, S. K., Neas, B. R., Segal, J. B., George, J. N. The incidence of immune thrombocytopenic purpura in children and adults: A critical review of published reports. Am. J. Hematol., 2010, 85, 3, p. 174-180. Go to original source... Go to PubMed...
    3. Schoonen, W. M., Kucera, G., Coalson, J., Li, L., Rutstein, M., Mowart, F., Fryzek, J., Kaye, J. A. Epidemiology of immune thrombocytopenic purpura in General Practice Research Database. Br. J. Haematol., 2009, 145, 5, p. 235-244. Go to original source... Go to PubMed...
    4. Cines, D. B., Blanchette, V. S. Immune thrombocytopenic purpura. N. Engl. J. Med., 2002, 346, 19, p. 995-1008. Go to original source... Go to PubMed...
    5. Cines, D. B., Liebman, H., Stasi, R. Pathobiology of secondary immune thrombocytopenia. Semin. Hematol., 2009, 46, 1, Suppl. 2, p. 2-14. Go to original source... Go to PubMed...
    6. DiMaggio, D., Anderson, A., Bussel, J. B. Cytomegalovirus can make immune thrombocytopenic purpura refractory. Br. J. Haematol., 2009, 146, 1, p. 104-112. Go to original source... Go to PubMed...
    7. Zhang, W., Nardi, M. A., Borkowsky, W., Li, Z., Karpatkin, S. Role of molecular mimicry of hepatitis C virus with platelet GPIIIa in hepatitis C-related immunologic thrombocytopenia. Blood, 2009, 113, 7, p. 4086-4093. Go to original source... Go to PubMed...
    8. Ustun, C., Dainer, P., Hendricks, L., Bruker, C. T., Burgess, R. Association of breast cancer and immune thrombocytopenic purpura. South Med. J., 2002, 95, 1, p. 1335-1337. Go to original source...
    9. Perricone, C., Ceccarelli, F., Nesher, G., Borella, E., Odeh, Q., Conti, F., Schoenfeld, Y., Valesini, G. Immune thrombocytopenic purpura (ITP) associated with vaccinations: a review of reported cases. Immunol. Res., 2014, 60, 2-3, p. 226-235. Go to original source... Go to PubMed...
    10. Aster, R. H., Curtis, B. R., McFarland, J. G., Bougie, D. W. Drug-induced immune thrombocytopenia: pathogenesis, diagnosis, and management. J. Thromb. Haemost., 2009, 7, 6, p. 911-918. Go to original source... Go to PubMed...
    11. Neunert, C., Noroozi, N., Norman, G., Buchanan, G. R., Goy, J., Nazi, I., Kelton, J. G., Arnold, D. M. Severe bleeding events in adults and children with primary immune thrombocytopenia: a systematic review. J. Thromb. Haemost., 2015, 13, 3, p. 457-464. Go to original source... Go to PubMed...
    12. Moulis, G., Palmaro, A., Montastruc, J. L. et al. Epidemiology of incident immune thrombocytopenia: a nationwide population-based study in France. Blood, 2014, 124, 22, p. 3308-3315. Go to original source... Go to PubMed...
    13. McMillan, R. The role of antiplatelet autoantibody assays in the diagnosis of immune thrombocytopenic purpura. Curr. Hematol. Rep., 2005, 4, 2, p. 160-165.
    14. Toltl, L. J., Arnold, D. M. Pathophysiology and management of chronic immune thrombocytopenia: focusing on what matter. Br. J. Haematol., 2011, 152, 1, p. 52-60. Go to original source... Go to PubMed...
    15. Cortelazzo, S., Finazzi, G., Buelli, M., Molteni, A., Viero, P., Barbiu, T. High risk of severe bleeding in aged patients with chronic idiopathic thrombocytopenic purpura. Blood, 1991, 77, 1, p. 31-33. Go to original source...
    16. Goel, R., Ness, P. M., Takemoto, C. M., Krishnamurti, L., King, K. E., Tobian, A. A. Platelet transfusions in platelet consumptive disorders are associated with arterial thrombosis and in-hospital mortality. Blood, 2015, 125, 9, p. 1470-1476. Go to original source... Go to PubMed...
    17. Ghanima, W., Godeau, B., Cines, D. B., Bussel, J. B. HowI treat immune thrombocytopenia: the choice between splenectomy or a medical therapy as a second-line treatment. Blood, 2012, 120, 5, p. 960-969. Go to original source... Go to PubMed...
    18. George, J. N. Management of patients with refractory immune thrombocytopenic purpura. J. Thromb. Haemost., 2006, 4, 8, p. 1664-1672. Go to original source... Go to PubMed...
    19. Braendstrup, P., Bjerrum, O. W., Nielsen, O. J. et al. Rituximab chimeric anti-CD20 monoclonal antibody treatment for adult refractory idiopathic thrombocytopenic purpura. Am. J. Hematol., 2005, 78, 4, p. 275-280. Go to original source... Go to PubMed...
    20. Neylon, A. J., Saunders, P. W., Howard, M. R., Proctor, S. J., Taylor, P. R. Clinically significant newly presenting autoimmune thrombocytopenic purpura in adults: a prospective study of a population-based cohort of 245 patients. Br. J. Haematol., 2003, 122, 6, p. 966-974. Go to original source... Go to PubMed...
    21. McMillan, R., Durette, C. Long-term outomes in adults with chronic ITP after splenectomy failure. Blood, 2004, 104, 4, p. 956-960. Go to original source... Go to PubMed...
    22. Portielje, J. E., Westendrop, R. G., Kliun-Nelemans, H. C., Brand, A. Morbidity and mortality in adults with idiopathic thrombocytopenic purpura. Blood, 2001, 97, 9, p. 2549-2554. Go to original source... Go to PubMed...
    23. Karpatkin, S. Autoimmune thrombocytopenic purpura. Blood, 1980, 56, 3, p. 329-343. Go to original source...
    24. Keeling, D. M., Isenberg, D. A. Haematological manifestation of systemic lupus erythematosus. Blood Rev., 1993, 7, 4, p. 199-207. Go to original source... Go to PubMed...
    25. Newman, K., Owlia, M. B., El-Hemaidi, I., Akhtari, M. Management of immune cytopenias in patients with systemic lupus erythematosus - old and new. Autoimmun. Rev., 2013, 10, 1, p. 784-791. Go to original source... Go to PubMed...
    26. Liebman, H. Other immune thrombocytopenias. Semin. Hematol., 2007, 44, 4, Suppl. 5, p. 24-34. Go to original source... Go to PubMed...

    Return to the content


    Anesteziologie a intenzivní medicína

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.