Anest. intenziv. Med. 2008;19(4):210-217
Antimicrobial protection options in central venous catheters - OverviewIntesive Care Medicine - Review Article
- Klinika anesteziologie, resuscitace a intenzivní medicíny FN Brno a LF MU Brno
Central venous catheters (CVC) take indispensable place in caring for critically ill patients. Catheter-related infections increase morbidity and mortality. In the article basic CVC protection methods are mentioned with accent on overview of catheters available on the market. Overviews of meta-analyses and several methodological flaws of recent studies are also referred. Meta-analyses showed that anti-infective CVCs reduce the risk of catheter-related blood stream infections, but their routinely use is still not recommended. However, the use of anti-infective CVCs should be considered, when background rates of catheter-related infections are high.
Keywords: central venous catheter; catheter-related infections; impregnated catheter; coated catheter; chlorhexidine; silver sulfadiazine; minocycline; rifampicin
Received: May 12, 2008; Accepted: June 12, 2008; Published: August 1, 2008 Show citation
References
- Edwards et al. National Healthcare Safety Network (NHSN) Report, data summary for 2006. Dostupné na: http://www.cdc.gov/ncidod/dhqp/nhsn_documents.html.
- Gastmeier, P., Zuschneid, I., Geffers, C. Antimicrobially impregnated catheters: An overview of randomized controlled trials. Journal of Vascular Access, 2003, 4, 3, p. 102-110.
- Horan, T. C., Gaynes, R. Surveillance of nosocomial infections. In Mayhall, C. G., ed. Hospital Epidemiology and Infection Control. Philadelphia: Lippincott Williams & Wilkins, 2004, p.1659-1702.
- Černý, V. et al. Sepse v intenzivní péči. 2. vyd., 2005, p. 28-29.
- Morales, M. et al. Biofilm: the microbial "bunker" for intravascular catheter-related infection. Support Care Cancer, 2004, 12, p. 701-707.
Go to original source...
Go to PubMed...
- Růžička, F. Biofilm a jeho význam. In Kurz antibiotické terapie. Praha, 2005.
- Modak, S. M., Sampath, L. Development and evaluation of a new polyurethane central venous antisepstic catheter. Complications Surg., 1992, 11, p. 23-29.
- Richards, B. et al. Effect of central venous catheter type on infections: a prospective clinical trial. The Journal of Hospital Infection, 2003, 54, 1, p. 10-17.
Go to original source...
Go to PubMed...
- van Vliet, J. et al. A comparison between two types of central venous catheters in the prevention of catheter-related infections: The importance of performing all the relevant cultures. Clinical Intensive Care, 2001, 12, 3, p. 135-140.
Go to original source...
- Tennenberg, S. et al. A prospective randomized trial of an antibiotic- and antiseptic-coated central venous catheter in the prevention of catheter-related infections. Archives of Surgery, 1997, 132, 12, p. 1348-1351.
Go to original source...
Go to PubMed...
- Logghe, C. et al. Evaluation of chlorhexidine and silver-sulfadiazine impregnated central venous catheters for the prevention of bloodstream infection in leukaemic patients: a randomized controlled trial. The Journal of Hospital Infection, 1997, 37, 2, p. 145-156.
Go to original source...
Go to PubMed...
- Ciresi, D. L. et al. Failure of antiseptic bonding to prevent central venous catheter-related infection and sepsis. The American Surgeon, 1996, 62, 8, p. 641-646.
Go to PubMed...
- Sheng, W. H. et al. Evaluation of antiseptic-impregnated central venous catheters for prevention of catheter-related infection in intensive care unit patients. Diagnostic Microbiology and Infectious Disease, 2000, 38, 1, p. 1-5.
Go to original source...
Go to PubMed...
- Dunser, M. W. et al. Central venous catheter colonization in critically ill patients: a prospective, randomized, controlled study comparing standard with two antiseptic-impregnated catheters. Anesthesia and Analgesia, 2005, 101, 6, p. 1778-1784.
Go to original source...
Go to PubMed...
- Maki, D. G. et al. Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter. A randomized, controlled trial. Annals of Internal Medicine, 1997, 127, 4, p. 257-266.
Go to original source...
Go to PubMed...
- Brun-Buisson, C. et al. Prevention of intravascular catheter-related infection with newer chlorhexidine-silver sulfadiazine-coated catheters: a randomized controlled trial. Intensive Care Medicine, 2004, 30, 5, p. 837-843.
Go to original source...
Go to PubMed...
- Rupp, M. E. et al. Effect of a second-generation venous catheter impregnated with chlorhexidine and silver sulfadiazine on central catheter-related infections: a randomized, controlled trial. Annals of Internal Medicine, 2005, 143, 8, p. 570-580.
Go to original source...
Go to PubMed...
- Ostendorf, T. et al. Chlorhexidine and silver-sulfadiazine coated central venous catheters in haematological patients - A double-blind, randomised, prospective, controlled trial. Supportive Care in Cancer, 2005, 13, 12, p. 993-1000.
Go to original source...
Go to PubMed...
- Stephens, R. et al. Two episodes of life-threatening anaphylaxis in the same patient to a chlorhexidine-sulphadiazine-coated central venous catheter. British Journal of Anaesthesia, 2001, 87, 2, p. 306-308.
Go to original source...
Go to PubMed...
- Raad, I. et al. Antibiotics and prevention of microbial colonization of catheters. Antimicrobial Agents and Chemotherapy, 1995, 39, 11, p. 2397-2400.
Go to original source...
Go to PubMed...
- Leon, C. et al. Benefits of minocycline and rifampin-impregnated central venous catheters. A prospective, randomized, double-blind, controlled, multicenter trial. Intensive Care Medicine, 2004, 30, 10, p. 1891-1899.
Go to original source...
Go to PubMed...
- Darouiche, R. O. et al. A comparison of two antimicrobial-impregnated central venous catheters. New England Journal of Medicine, 1999, 340, 1, p. 1-8.
Go to original source...
Go to PubMed...
- Fraenkel, D. et al. A prospective, randomized trial of rifampicin-minocycline-coated and silver-platinum-carbon-impregnated central venous catheters. Critical Care Medicine, 2006, 34, 3, p. 668-675.
Go to original source...
Go to PubMed...
- Falagas, M. E. et al. Rifampicin-impregnated central venous catheters: A meta-analysis of randomized controlled trials. Journal of Antimicrobial Chemotherapy, 2007, 59, 3, p. 359-369.
Go to original source...
Go to PubMed...
- Niël-Weise, B. S., Stijnen, T., van den Broek, P. J. Anti-infective-treated central venous catheters: a systematic review of randomized controlled trials. Intensive Care Med., 2007, 12, 33, p. 2058-2068.
Go to original source...
Go to PubMed...
- Guggenbichler, J.-P. et al. A New Technology of Microdispersed Silver in Polyurethane Induces Antimicrobial Activity in Central Venous Catheters. Infection, 1999, 27, Suppl. 1, p. S16-S23.
Go to original source...
Go to PubMed...
- Bechert, T. et al. The Erlanger Silver Catheter: In Vitro Results for Antimicrobial Activity. Infection, 1999, 27, Suppl. 1, p. S24-S29.
Go to original source...
Go to PubMed...
- Boswald, M. et al. Reduced rates of catheter-associated infection by use of a new silver-impregnated central venous catheter. Infection, 1999, 27, Suppl. 1, p. S56-60.
Go to original source...
Go to PubMed...
- Goldschmidt, H. et al. Prevention of catheter-related infections by silver coated central venous catheters in oncological patients. Zentralblatt für Bakteriologie : International Journal of Medical Microbiology, 1995, 283, 2, p. 215-223.
Go to original source...
Go to PubMed...
- Furno, F. et al. Silver nanoparticles and polymeric medical devices: a new approach to prevention of infection? J. Antimicrob. Chemother., 2004, 54, p. 1019-1024.
Go to original source...
Go to PubMed...
- Moretti, E. W. et al. Impact of central venous catheter type and methods on catheter-related colonization and bacteraemia. The Journal of Hospital Infection, 2005, 61, 2, p. 139-145.
Go to original source...
Go to PubMed...
- Yorganci, K. et al. In Vitro Evaluation of the Antibacterial Activity of Three Different Central Venous Catheters Against Gram-Positive Bacteria. Eur. J. Clin. Microbiol. Infect. Dis., 2002, 21, p. 379-384.
Go to original source...
Go to PubMed...
- Ranucci, M. et al. Impact of oligon central venous catheters on catheter colonization and catheter-related bloodstream infection. Crit. Care Med., 2003, 31, 1, p. 52-59.
Go to original source...
Go to PubMed...
- Kalfon, P. et al. Comparison of silver-impregnated with standard multi-lumen central venous catheters in critically ill patients. Crit. Care Med., 2007, 35, 4, p. 1032-1039.
Go to original source...
Go to PubMed...
- Walz, J. M. et al. A multicenter randomized controlled clinical trial comparing central venous catheters impregnated with either 5-Fluorouracil or chlorhexidine/silver sulfadiazine in preventing catheter colonization. 28th International Symposium on Intensive Care and Emergency Medicine, Brussels, March 18-21, 2008.
Go to original source...
- Scott, A. et al. Do Antimicrobial-Impregnated Central Venous Catheters Prevent Catheter-Related Bloodstream Infection? Clinical Infectious Diseases, 2003, 37, p. 65-72.
Go to original source...
Go to PubMed...
- Crnich, C. J., Maki, D. G. Are antimicrobial-impregnated catheters effective? Don't throw out the baby with the bathwater. Clin. Infect. Diseases, 2004, 38, 9, p. 1287-1292.
Go to original source...
Go to PubMed...
- Carrasco, M. N. et al. Evaluation of a triple-lumen central venous heparin-coated catheter versus a catheter coated with chlorhexidine and silver sulfadiazine in critically ill patients. Intensive Care Medicine, 2004, 30, 4, p. 633-638.
Go to original source...
Go to PubMed...
- Collin, G. R. Decreasing catheter colonization through the use of an antiseptic-impregnated catheter: a continuous quality improvement project. Chest, 1999, 115, 6, p. 1632-1640.
Go to original source...
Go to PubMed...
- Cicalini, S., Palmieri, F., Petrosillo, N. Clinical review: New technologies for prevention of intravascular catheter-related infections. Critical Care, 2004, 8, 3, p. 157-162.
Go to original source...
Go to PubMed...
- Eggimann, P. Prevention of intravascular catheter infection. Current Opinion in Infectious Diseases, 2007, 20, 4, p. 360-369.
Go to original source...
Go to PubMed...
- O'Grady, N. et al. Guidelines for the prevention of intravascular catheter-related infections. Infection Control and Hospital Epidemiology, 2002, 23, 12, p. 759-769.
Go to original source...