Anest. intenziv. Med. 2025;36(2):139-141 | DOI: 10.36290/aim.2025.018

Commentary on the standard operating procedure NIKEZ Algorithm for the diagnosis of malignant hyperthermia in the Czech Republic and its practical consequencesCorrespondence

Štěpánková D.1, 2, Klincová M.1, 2, 3, Schröderová I.1, 4, Zídková J.1, 5, 6, Gaillyová R.1, 6, Fajkusová L.1, 5, 6, 7, Vyškovský R.8, Štourač P.1, 2, 3
1 Akademické centrum pro maligní hypertermii, Lékařská fakulta Masarykovy univerzity, Brno
2 Klinika dětské anesteziologie a resuscitace, Fakultní nemocnice Brno a Lékařská fakulta Masarykovy univerzity, Brno
3 Ústav simulační medicíny Lékařské fakulty Masarykovy univerzity, Brno
4 Anesteziologicko­‑resuscitační klinika, Fakultní nemocnice u sv. Anny a Lékařská fakulta Masarykovy univerzity, Brno
5 Centrum molekulární biologie a genetiky, Interní hematologická a onkologická klinika, Fakultní nemocnice Brno a Lékařská fakulta Masarykovy univerzity, Brno
6 Ústav lékařské genetiky a genomiky, Fakultní nemocnice Brno a Lékařská fakulta Masarykovy univerzity, Brno
7 Národní centrum pro výzkum biomolekul, Přírodovědecká fakulta Masarykovy univerzity, Brno
8 Institut biostatistiky a analýzy, s. r. o., Brno

Received: April 9, 2025; Revised: April 9, 2025; Accepted: April 23, 2025; Prepublished online: June 19, 2025; Published: June 27, 2025  Show citation

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Štěpánková D, Klincová M, Schröderová I, Zídková J, Gaillyová R, Fajkusová L, et al.. Commentary on the standard operating procedure NIKEZ Algorithm for the diagnosis of malignant hyperthermia in the Czech Republic and its practical consequences. Anest. intenziv. Med. 2025;36(2):139-141. doi: 10.36290/aim.2025.018.
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    References

    1. . Klincová M, Štěpánková D, Schröderová I, Klabusayová E, Ošťádalová E, Valášková I, et al. 20 let diagnostiky maligní hypertermie v České a Slovenské republice. Anest Intenziv Med. 2023;34(3):103-9. Go to original source...
    2. . Klincová M, Štěpánková D, Schröderová I, Klabusayová E, Ošťádalová E, Valášková I, et al. Malignant hyperthermia in Czechia and Slovakia. Br J Anaesth. 2022 Aug;129(2):e41-3. Go to original source... Go to PubMed...
    3. . Hopkins PM, Rüffert H, Snoeck MM, Girard T, Glahn KPE, Ellis FR, et al; European Malignant Hyperthermia Group. European Malignant Hyperthermia Group guidelines for investigation of malignant hyperthermia susceptibility. Br J Anaesth. 2015 Oct;115(4):531-9. Go to original source... Go to PubMed...
    4. . Štourač P, Štěpánková D, Klincová M, Schröderová I, Zídková J, Gaillyová R, et al. Algoritmus diagnostiky maligní hypertermie. Operativní doporučení. [Internet]. NIKEZ. 2025 [citováno 2025 Břez 30]. Available from: https://nikez.mzcr.cz/guideline/354-algoritmus­‑diagnostiky­‑maligni­‑hypertermie/.
    5. . Rüffert H, Bastian B, Bendixen D, Girard T, Heiderich S, Hellblom A, et al. Consensus guidelines on perioperative management of malignant hyperthermia suspected or susceptible patients from the European Malignant Hyperthermia Group. Br J Anaesth. 2021 Jan;126(1):120-30. Go to original source... Go to PubMed...
    6. . Hopkins PM, Girard T, Dalay S, Jenkins B, Thacker A, Patteril M, et al. Malignant hyperthermia 2020: Guideline from the Association of Anaesthetists. Anaesthesia. 2021 May;76(5):655-64. Go to original source... Go to PubMed...
    7. . Glahn KPE, Ellis FR, Halsall PJ, Müller CR, Snoeck MMJ, Urwyler A, et al. Recognizing and managing a malignant hyperthermia crisis: guidelines from the European Malignant Hyperthermia Group. Br J Anaesth. 2010 Oct;105(4):417-20. Go to original source... Go to PubMed...
    8. . Glahn KPE, Girard T, Hellblom A, Hopkins P, Johannsen S, Rueffert H, et al. Recognising and managing a malignant hyperthermia crisis (v2024) [Internet]. EMHG. [citováno 2024 Pros 16]. Available from: https://www.emhg.org/recommendations-1/2024/11/4/recognising­‑and­‑managing­‑a-malignant­‑hyperthermia­‑crisis­‑v2024.
    9. . Glahn KPE, Bendixen D, Girard T, Hopkins PM, Johannsen S, Rüffert H, et al. European Malignant Hyperthermia Group. Availability of dantrolene for the management of malignant hyperthermia crises: European Malignant Hyperthermia Group guidelines. Br J Anaesth. 2020 Aug;125(2):133-40. Go to original source... Go to PubMed...
    10. . Larach MG, Klumpner TT, Brandom BW, Vaughn MT, Belani KG, Herlich A, et al. Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review. Anesthesiology. 2019 Jan;130(1):41-54. Go to original source... Go to PubMed...
    11. . Klincová M, Štěpánková D, Schröderová I, Klabusayová E, Štourač P. Malignant Hyperthermia in PICU­‑From Diagnosis to Treatment in the Light of Up­‑to­‑Date Knowledge. Child Basel Switz. 2022 Nov 4;9(11):1692. Go to original source... Go to PubMed...
    12. . Litman RS, Griggs SM, Dowling JJ, Riazi S. Malignant Hyperthermia Susceptibility and Related Diseases. Anesthesiology. 2018 Jan;128(1):159-67. Go to original source... Go to PubMed...
    13. . Gupta PK, Bilmen JG, Hopkins PM. Anaesthetic management of a known or suspected malignant hyperthermia susceptible patient. BJA Educ [Internet]. 2021 Jun 1. 21(6):218-24. [cited 2024 Pros 16]. Available from: https://www.bjaed.org/article/S2058-5349(21)00006-8/fulltext. Go to original source... Go to PubMed...
    14. . Schieren M, Defosse J, Böhmer A, Wappler F, Gerbershagen MU. Anaesthetic management of patients with myopathies. Eur J Anaesthesiol. 2017 Oct;34(10):641-9. Go to original source... Go to PubMed...
    15. . van den Bersselaar LR, Hellblom A, Gashi M, Kamsteeg EJ, Voermans NC, Jungbluth H, et al. Referral Indications for Malignant Hyperthermia Susceptibility Diagnostics in Patients without Adverse Anesthetic Events in the Era of Next­‑generation Sequencing. Anesthesiology. 2022 Jun 1;136(6):940-53. Go to original source... Go to PubMed...
    16. . Churová V, Vyškovský R, Maršálová K, Kudláček D, Schwarz D. Anomaly Detection Algorithm for Real-World Data and Evidence in Clinical Research: Implementation, Evaluation, and Validation Study. JMIR Med Inform. 2021 May 7;9(5):e27172. doi: 10.2196/27172. PMID: 33851576; PMCID: PMC8140384. Go to original source... Go to PubMed...
    17. . Štěpánková D, Klincová M, Schröderová I, Klabusayová E, Kusalová K, Zídková J, et al. Význam nové zabezpečené elektronické databáze maligní hypertermie pro zefektivnění práce ACMH a zlepšení poradenství v České a Slovenské republice. In XXX. kongres České společnosti anesteziologie a intenzivní medicíny. 2024. ISSN 1214-2158.

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