Anest. intenziv. Med. 2024;35(2):104-115 | DOI: 10.36290/aim.2024.023

Management of amniotic fluid embolismReview Article

Pešková K.1, 3, Štourač P.2-4, Seidlová D.1, 3
1 II. anesteziologicko-resuscitační oddělení, Fakultní nemocnice Brno
2 Klinika dětské anesteziologie a resuscitace, Fakultní nemocnice Brno
3 Lékařská fakulta Masarykovy univerzity, Brno
4 Ústav simulační medicíny, Lékařská fakulta Masarykovy univerzity, Brno

Amniotic fluid embolism is characterized by sudden cardiorespiratory collapse during labor or soon after delivery. We present immediate management when a rapid response is critical. The appearance of disseminated intravascular coagulation confirms high suspicion of the diagnosis plausibly. We remind administration of tranexamic acid and fibrinogen. Fibrinogen is preferred over plasma to minimize the risk of volume overload. Avoidance of fluid overload is an important management principle of pulmonary hypertension and right heart failure. Inotropes and pulmonary vasodilators are the mainstays of therapy. Although the therapeutic application of C1 esterase inhibitor concentrate is proposed in articles, the real application is reported sporadically. Extracorporeal membrane oxygenation can be considered.

Keywords: amniotic fluid embolism, immunomodulation, treatment strategies.

Received: December 20, 2023; Revised: April 7, 2024; Accepted: May 13, 2024; Prepublished online: June 5, 2024; Published: June 24, 2024  Show citation

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Pešková K, Štourač P, Seidlová D. Management of amniotic fluid embolism. Anest. intenziv. Med. 2024;35(2):104-115. doi: 10.36290/aim.2024.023.
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