Anest. intenziv. Med. 2023;34(4):152-156 | DOI: 10.36290/aim.2023.053

Five most important drug interactions in the critically illReview Article

Rychlíčková J.^{1, 2}, Suk P.^{1, 3}

¹ International Clinical Research Center, Fakultní nemocnice u sv. Anny v Brně, Brno

² Farmakologický ústav, Lékařská fakulta, Masarykova univerzita, Brno

³ Anesteziologicko­‑resuscitační klinika, FN u sv. Anny v Brně a Lékařská fakulta, Masarykova univerzita, Brno

The prevalence of drug interactions in the critically ill is high, but these are often potential drug interactions of limited clinical relevance. This paper aims to describe the mechanism and management of not the most frequent but, according to the authors, the most clinically significant interactions. These top five interactions include carbapenems and valproate, CYP 3A4 inhibitors and ticagrelor, enteral nutrition and levodopa, combinations of QT prolonging drugs, and CYP 3A4 inhibitors and quetiapine.

Keywords: drug interactions, critical care, drug side effects, long QT syndrome, cytochrome P-450 enzyme enhibitors.

Received: August 28, 2023; Revised: October 31, 2023; Accepted: November 7, 2023; Prepublished online: November 29, 2023; Published: December 15, 2023  Show citation