Anest. intenziv. Med. 2013;24(3):163-167

Sugammadex for active reversal of neuromuscular blockade induced by rocuronium for Caesarean section in general anaesthesia - series of case reportsAnaesthesiology - Case Reports

Štourač Petr^1,*, Kosinová Martina¹, Bártíková Ivana¹, Klučka Jozef¹, Křikava Ivo¹, Štoudek Roman¹, Harazim Hana¹, Huser Martin², Janků Petr², Gál Roman¹

¹ Klinika anesteziologie, resuscitace a intenzivní medicíny FN Brno a LF MU, Brno

² Gynekologicko-porodnická klinika FN Brno a LF MU, Brno

Sugammadex is a selective relaxant-binding agent, which reverses rocuronium-induced neuromuscular blocks of any depth. We reported six Caesarean sec-tion cases undergoing general anaesthesia with propofol(1.6-2.3 mg/kg) or thiopental (4.1-5.6 mg/kg) and rocuronium (0.8-1.1 mg/kg) or sukcinylcholin(1.0-1.5 mg/kg) for the induction of neuromuscular blockade. Rocuronium was used for the maintenance of neromuscular blockade (0.4-0.5 mg/kg). At the end of the procedure, all the patients had a significant degree of neuromuscular block. In one patient, there was no single twitch response and no TOF-ratio, three patients had shallow neuromuscular blockade (TOF > 1) and two of them had no clinical signs of neuromuscular recovery (TOF monitoring not used). The same single dose of sugammadex 200 mg (1.7-3.2 mg/kg) was given. In all patients, sugammadex provided rapid and sufficient reversal to full muscle strenght. All patients were monitored after the operation and no signs of recurarization or neuromuscular weakness were observed.

Keywords: sugammdex; Caesarean section; general anaesthesia; neuromusclar blockade; Rapid Sequence Induction

Received: January 26, 2013; Accepted: February 26, 2013; Published: June 1, 2013  Show citation