Anest. intenziv. Med. 2012;23(4):183-187

Risks of anaesthesia in children with Angelman syndromeAnaesthesiology - Review articles

Hladíková Andrea1,*, Olos Tomáš2, Hladík Michal2, Šilhánová Eva1
1 Oddělení lékařské genetiky, FN Ostrava
2 Klinika dětského lékařství FN Ostrava a LF Ostravské univerzity

The authors would like to make you aware of the unpredictable effects of anaesthetic agents in children with Angelman syndrome (a rare neuro-genetic disorder characterized by intellectual and developmental disability, epilepsy, sleep disturbance, seizures, jerky movements - especially hand-flapping, frequent laughter or smiling, usually a happy demeanour, microcephaly, plagiocephaly, prominent mandible, wide mouth, wide-spaced teeth, hypopigmentation, tongue thrusting, suck/swallowing disorders). Especially vagal hypertonia resulting in cardiac rhythm disturbances and asystole should be considered in the peri-operative care of these patients. Their recovery may be unpredictable and complicated.

Keywords: Angelman syndrome; anaesthetic risk; difficult airway; vagal hypertonia

Received: April 30, 2012; Accepted: June 12, 2012; Published: August 1, 2012  Show citation

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Hladíková A, Olos T, Hladík M, Šilhánová E. Risks of anaesthesia in children with Angelman syndrome. Anest. intenziv. Med. 2012;23(4):183-187.
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