Anest. intenziv. Med. 2012;23(1):21-27

Influence of age and gender on the pharmacodynamic parameters of rocuronium during total intravenous anaesthesia - a prospective studyAnaesthesiology - Original Paper

Adamus Milan1,*, Hrabálek Lumír2, Wanek Tomáš2, Gabrhelík Tomáš1, Zapletalová Jana3,4
1 Klinika anesteziologie, resuscitace a intenzivní medicíny, Fakultní nemocnice a Lékařská fakulta Univerzity Palackého v Olomouci
2 Neurochirurgická klinika, Fakultní nemocnice a Lékařská fakulta Univerzity Palackého v Olomouci
3 Ústav lékařské biofyziky, Lékařská fakulta Univerzity Palackého v Olomouci
4 Institut molekulární a translační medicíny, Lékařská fakulta Univerzity Palackého v Olomouci

Influence of age and gender on the pharmacodynamic parameters of rocuronium during total intravenous anaesthesia - a prospective study




Objective:
To compare the pharmacodynamics of 0.6 mg . kg-1 rocuronium in young and older patients of both genders during total intravenous anaesthesia.

Design:
Clinical, observational, non-blinded study.


Setting:
Department of Anaesthesiology, University Hospital.

Materials and methods:
Following local ethics committee approval and informed consent, patients scheduled for surgery under total intravenous anesthesia (propofol/sufentanil) were divided into 4 study groups: 37 males aged 20-40, 40 males aged 60-75 yrs, 43 females aged 20-40 and 38 females aged 60-75 yrs. Neuromuscular block following rocuronium (0.6 mg kg-1) was monitored as follows: train-of-four [TOF] stimulation of the ulnar nerve at 15-s intervals, EMG of the adductor pollicis muscle. The onset time (from application of rocuronium to maximum depression of T1), clinical duration (from application to 25% recovery of T1), and time to full spontaneous recovery (from application to TOF-ratio ≥ 0.9) were determined for each patient. The Kruskal-Wallis test was used to compare differences between the groups; P < 0.05 was considered statistically significant.

Results:
The onset time (median [interquartile range]) in the respective groups was 90 [80-110]BCD, 135 [116-165]AC, 75 [60-90]ABD, and 120 [90-146]AC seconds. The clinical duration was 30 [25-42]BCD, 58 [53-67]AD, 50 [40-65]AD, and 85 [70-90]ABC min. The interval to full spontaneous recovery was 59 [51-67]BCD, 102 [75-106]A, 76 [66-91]AD, and 128 [94-137]AC min. (AP

Keywords: rocuronium; neuromuscular blockade; age; gender

Received: January 6, 2012; Accepted: January 15, 2012; Published: February 1, 2012  Show citation

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Adamus M, Hrabálek L, Wanek T, Gabrhelík T, Zapletalová J. Influence of age and gender on the pharmacodynamic parameters of rocuronium during total intravenous anaesthesia - a prospective study. Anest. intenziv. Med. 2012;23(1):21-27.
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