Anest. intenziv. Med. 2010;21(3):158-164

Multiple organ dysfunction syndrome (MODS) - from molecules to the bedsideIntesive Care Medicine - Review Article

Chvojka Jiří, Raděj Jaroslav, Karvunidis Thomas, Kroužecký Aleš, Novák Ivan, Matějovič Martin*
I. interní klinika, Jednotka intenzivní péče, Univerzita Karlova v Praze, Lékařská fakulta v Plzni a Fakultní nemocnice Plzeň

Multiple organ dysfunction syndrome (MODS) is one of the most common causes of death in the intensive care units. This review summarizes recent progress in our understanding of the pathophysiological mechanisms leading to MODS including the concept of mitochondrial dysfunction and apoptosis. The crucial therapeutic measures are early and adequate haemodynamic resuscitation together with elimination of the causative factors. Prevention of iatrogenic insults, potentially worsening MODS, should be an integral part of the therapeutic approach.

Keywords: multiple organ dysfunction syndrome; sepsis; shock; pathophysiology; therapy; intensive care; organ support

Published: June 1, 2010  Show citation

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Chvojka J, Raděj J, Karvunidis T, Kroužecký A, Novák I, Matějovič M. Multiple organ dysfunction syndrome (MODS) - from molecules to the bedside. Anest. intenziv. Med. 2010;21(3):158-164.
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