Anest. intenziv. Med. 2007;18(5):282-285

Fibrinolysis and its management in cardiac surgeryAnaesthesiology - Review articles

T. Vaněk, J. Šnircová
Kardiochirurgická klinika 3. LF UK a FNKV, Praha

The article summarizes current knowledge of fibrinolysis and fibrinolytic inhibitors in cardiac surgery. It deals with the effectiveness and safety of antifibrinolytic therapy in "on-pump" and "off-pump" cardiac surgery.

Keywords: cardiac surgery; fibrinolysis; aprotinin; tranexamic acid

Published: October 1, 2007  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Vaněk T, Šnircová J. Fibrinolysis and its management in cardiac surgery. Anest. intenziv. Med. 2007;18(5):282-285.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Engoren, M. C., Habib, R. H., Zacharias, A., Schwann, T. A., Riordan, Ch. J., Durham, S. J. Effect of blood transfusion on long-term survival after cardiac operation. Ann. Thorac. Surg., 2002, 74, 4, p. 1180-1186. Go to original source... Go to PubMed...
    2. Koch, C. G., Li, L., Duncan, A. I., Mihaljevic, T., Cosgrove, D. M., Loop, F. D., Starr, N. J., Blackstone, E. H. Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting. Crit. Care Med., 2006, 34, 6, p. 1608-1616. Go to original source... Go to PubMed...
    3. Royston, D., Bidstrup, B. P., Taylor, K. M., Sapsford, R. N. Effect of aprotinin on need for blood transfusion after repeat open-heart surgery. Lancet, 1987, 2, 8571, p. 1289-1291. Go to original source... Go to PubMed...
    4. Royston, D., Van Haaften, N., De Vooght, P. Aprotinin; friend or foe? A review of recent medical literature. Eur. J. Anaesthesiol., 2007, 24, 1, p. 6-14. Go to original source...
    5. Biglioli, P., Cannata, A., Almanni, F., Naliato, M., Porqueddu, M., Zanobini, M., Tremoli, E., Parolari, A. Biological effects of off-pump vs. on-pump coronary artery surgery: focus on inflammation, hemostasis and oxidative stress. Eur. J. Cardiothorac. Surg., 2003, 24, 2, p. 160-269. Go to original source... Go to PubMed...
    6. Cvachovec, K., Horáček, M., Vislocký, I. A retrospective survey of fibrinolysis as an indicator of poor outcome after cardiopulmonary bypass and a possible early sign of systemic inflammatory syndrome. Eur. J. Anaesthesiol., 2000, 17, 3, p. 173-176. Go to original source...
    7. Jareš, M., Vaněk, T., Bednář, F., Malý, M., Šnircová, J., Straka, Z. Off-pump versus on-pump coronary artery surgery - Identification of fibrinolysis using rotation thromboelastography; a preliminary, prospective, randomized study. Int. Heart J., 2007, 48, 1, p. 57-67. Go to original source... Go to PubMed...
    8. Vaněk, T., Jareš, M., Šnircová, J., Malý, M. Fibrinolysis in coronary artery surgery: detection by thromboelastography. Interact. Cardiovasc. Thorac. Surg. (in press), Epub ahead of print - dostupné na www.icvts.org.
    9. Landis, R. C., Haskard, D. O., Taylor, K. M. New antiinflammatory and platelet-preseving effects of aprotinin. Ann. Thorac. Surg., 2001, 72, 5, p. S1808-S1813. Go to original source... Go to PubMed...
    10. Poullis, M., Manning, R., Laffan, M., Haskard, D. O., Taylor, K. M., Landis, R. C. The antithrombotic effect of aprotinin: actions mediated via the proteaseactivated receptor 1. J. Thorac. Cardiovasc. Surg., 2000, 120, 2, p. 370-378. Go to original source... Go to PubMed...
    11. McEvoy, M. D., Reeves, S. T., Reves, J. G., Spinale, F. G. Aprotinin in cardiac surgery: a review of conventional and novel mechanisms of action. Anesth. Analg., 2007, 105, 4, p. 949-962. Go to original source... Go to PubMed...
    12. Ashraf, S., Tian, Y., Cowan, D., Nair, U., Chatrath, R., Saunders, N. R., Watterson, K. G., Martin, P. G. "Low-dose" aprotinin modifies hemostasis but not proinflammatory cytokine release. Ann. Thorac. Surg., 1997, 63, 1, p. 68-73. Go to original source... Go to PubMed...
    13. Lei, Y., Haider, H. Kh., Chusnsheng, W., Zhigiang, C., Hao, C., Kejian, H., Qiang, Z. Dose-dependent effect of aprotinin on aggravated pro-inflammatory cytokines in patients with pulmonary hypertension following cardiopulmonary bypass. Cardiovasc. Drugs Ther., 2003, 17, 4, p. 343-348. Go to original source... Go to PubMed...
    14. Hill, G. E., Diego, R. P., Stammers, A. H., Huffman, S. M., Pohorecki, R. Aprotinin enhances the endogenous release of interleukin-10 after cardiac operations. Ann. Thorac. Surg., 1998, 65, 1, p. 66-69. Go to original source... Go to PubMed...
    15. Harig, F., Feyer, R., Mahmoud, F. O., Blum, U., von der Emde, J. Reducing the post-pump syndrome by using heparin coated circuits, steroids, or aprotinin. Thorac. Cardiovasc. Surg., 1999, 47, 2, p. 111-118. Go to original source... Go to PubMed...
    16. Landis, R. C., Asimakopoulos, G., Poullis, M., Haskard, D. O., Taylor, K. M. The antithrombotic and antiinflammatory mechanisms of action of aprotinin. Ann. Thorac. Surg., 2001, 72, 6, p. 2169-2175. Go to original source... Go to PubMed...
    17. Clark, S. C. Lung injury after cardiopulmonary bypass. Perfusion, 2006, 21, 4, p. 225-228. Go to original source... Go to PubMed...
    18. Sodha, N. R., Boodhwani, M., Bianchi, C., Ramalawi, B., Sellke, F. W. Aprotinin in cardiac surgery. Expert Rev. Cardiovasc. Ther., 2006, 4, 2, p. 151-160. Go to original source... Go to PubMed...
    19. Kincaid, E. H., Ashburn, D. A., Hoyle, J. R., Reichert, M. G., Hammon, J. W., Kon, N. D. Does the combination of aprotinin and angiotensin-converting enzyme inhibitor cause renal failure after cardiac surgery? Ann. Torac. Surg., 2005, 80, 4, p. 1388-1393. Go to original source... Go to PubMed...
    20. Casati, V., Guzzon, D., Oppizzi, M., Belloti, F., Franco, A., Gerli, C., Cossolini M., Torri, G., Calori, G., Benussi, S., Alfieri O. Tranexamic acid compared with high-dose aprotinin in elective heart operations: effects on perioperative bleeding and allogenic transfusions. J. Thorac. Cardiovasc. Surg., 2000, 120, 3, p. 520-527. Go to original source... Go to PubMed...
    21. Levi, M., Cromheecke, M. E., de Jonge, E., Prins, M. H., de Mol, B. J. M., Briët, E., Büller, H. R. Pharmacological strategies to decrease excessive blood loss in cardiac surgery: a meta-analysis of clinically relevant endpoints. Lancet, 1999, 354, 9194, p. 1940-1947. Go to original source... Go to PubMed...
    22. Sedrakyan, A., Treasure, T., Elefteriades, J. A. Effect of aprotinin on clinical outcomes in coronary artery bypass surgery: a systematic review and meta-analysis of randomized clinical trials. J. Thorac. Cardiovasc. Surg., 2004, 128, 3, p. 442-448. Go to original source... Go to PubMed...
    23. Brown, J. R., Birkmeyer, N. J., O'Connor, G. T. Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation, 2007, 115, 22, p. 2801-2813. Go to original source... Go to PubMed...
    24. Casati, V., Gerli, C., Franco, A., Torri, G., D'Angelo, A., Benussi, S., Alfieri, O. Tranexamic acid in off-pump coronary surgery: a preliminary, randomized, double-blind, placebo controlled study. Ann. Thorac. Surg., 2001, 72, 2, p. 470-475. Go to original source... Go to PubMed...
    25. Jareš, M., Vaněk, T., Straka, Z., Brůček, P. Tranexamic acid reduces bleeding after off-pump coronary artery bypass grafting. J. Cardiovasc. Surg., 2003, 44, 2, p. 205-208.
    26. Casati, V., Della Vale, P., Benussi, S., Franco, A., Gerli, C., Baili, P., Alfieri, O., D'Angelo, A. Effects of tranexamic acid on postoperative bleeding and related hematological variables in coronary surgery; Comparison between on-pump and off-pump techniques. J. Thorac. Cardiovasc. Surg., 2004, 128, 1, p. 83-91. Go to original source... Go to PubMed...
    27. Vaněk, T., Jareš, M., Fajt, R., Straka, Z., Jirásek, K., Kolesár, M., Brůček, P., Malý, M. Fibrinolytic inhibitors in off-pump coronary surgery: a prospective, randomized, double-blind TAP study (tranexamic acid, aprotinin, placebo). Eur. J. Cardiothorac. Surg., 2005, 28, 4, p. 563-568. Go to original source... Go to PubMed...
    28. Wei, M., Jian, K., Guo, Z., Li, P., Han, J., Cai, Z., Tarkka, M. Effect of half-dose aprotinin in off-pump coronary artery bypass grafting. World J. Surg., 2006, 30, 6, p. 1108-1114. Go to original source... Go to PubMed...
    29. Murphy, G. J., Mango, E., Lucchetti, V., Battaglia, F., Catapano, D., Rogers, C. A., Angelini, G. D. A randomized trial of tranexamic acid in combination with cell salvage plus a meta-analysis of randomized trials evaluating tranexamic acid in off-pump coronary artery bypass grafting. J. Thorac. Cardiovasc. Surg., 2006, 132, 3, p. 475-480. Go to original source... Go to PubMed...
    30. Alderman, E. L., Levy, J. H., Rich, J. B., Nili, M., Vidine, B., Schaff, H., Uretzky, G., Petterson, G., Thiis, J. J., Hantler, Ch. B., Chaitman, B., Nadel, A. Analyses of coronary graft patency after aprotinin use: results from the International Multicenter Aprotinin Graft Patency Experience (IMAGE) trial. J. Thorac. Cardiovasc. Surg., 1998, 116, 5, p. 716-730. Go to original source... Go to PubMed...
    31. Karkouti, K., Beattie, W. S., Dattilo, M. D., McCluskey, S. A., Ghannam, M., Hamdy, A., Wijeysundera, D. N., Fedorko, L., Yau, T. M. A propensity score case-control comparison of aprotinin and tranexamic acid in high-transfusion-risk cardiac surgery. Transfusion, 2006, 46, 3, p. 327-338. Go to original source... Go to PubMed...
    32. Mangano, D. T., Tudor, I. C., Dietzel, C., Multicenter Study of Perioperative Ischemia Research Group; Ischemia Research and Education Foundation. The risk associated with aprotinin in cardiac surgery. N. Engl. J. Med., 2006, 354, 4, p. 353-365. Go to original source... Go to PubMed...
    33. Mariani, M., Gu, Y. J., Boonstra, P. W., Grandjean, J. G., van Oeveren, W., Ebels, T. Procoagulant activity after off-pump coronary operation: is the current anticoagulation adequate? Ann. Thorac. Surg., 1999, 67, 5, p. 1370-1375. Go to original source... Go to PubMed...
    34. Bednář, F., Vaněk, T., Osmančík, P., Móciková, H., Jareš, M., Straka, Z., Widimský, P. Does platelet hyperactivity exist after off-pump compared to on-pump coronary artery surgery? J. Am. Coll. Cardol., 2006, 47, 4, Suppl. A, p. 190A.
    35. Poston, R. S., White, C., Gu, J., Brown, J., Gammie, J., Pierson, R. N., Lee, A., Connerney, I., Avari, T., Christenson, R., Tandry, U., Griffith, B. P. Aprotinin shows both hemostatic and antithrombotic effects during off-pump coronary artery bypass grafting. Ann. Thorac. Surg., 2006, 81, 1, p. 104-111. Go to original source... Go to PubMed...
    36. Poston, R. S., Gu, J., Brown, J. M., Gammie, J. S., White, C., Nie, L., Pierson, R. N., Griffith, B. P. Endothelial injury and acquired aspirin resistance as promoters of regional thrombin formation and early vein graft failure after coronary artery bypass grafting. J. Thorac. Cardiovasc. Surg., 2006, 131, 1, p. 122-130. Go to original source... Go to PubMed...
    37. Vaněk, T., Jareš, M., Straka, Z., MSM0021620817 Study Group. Aprotinin reduces troponin I levels in OPCABG. Ann. Thorac Surg., 2006, 82, 5, p. 1950-1951. Go to original source... Go to PubMed...
    38. Poston, R., Toshinaga, O. Reply. Ann. Thorac Surg., 2006, 82, 5, p. 1951-1952. Go to original source...
    39. Hendrikx, M., Rega, F., Jamaer, L., Valkenborgh, T., Gutermann, H., Mees, U. Na(+)/H(+)-exchange inhibition and aprotinin administration: promising tools for myocardial protection during minimally invasive CABG. Eur. J. Cardiothorac. Surg., 2001, 19, 5, p. 633-639. Go to original source... Go to PubMed...
    40. Baric, D., Biocina, B., Unic, D., Sutlic, Z., Rudez, I., Bacic Vrca, V., Brkic, K., Ivkovic, M. Topical use of antifibrinolytic agents reduces postoperative bleeding: a double blind, prospective, randomized study. Eur. J. Cardiothorac. Surg., 2007, 31, 3, p. 366-371. Go to original source... Go to PubMed...

    Return to the content


    Anesteziologie a intenzivní medicína

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.