Anest. intenziv. Med. 2000;11(6):267-270

The Effect of Continuous Veno-venous Hemofiltration on T lymphocytes and Monocytes Activation in Critically Ill Patients in SepsisArticles

J. Příhodová⁴, M. Holub¹, J. Hanzlíková³, M. Matějovič², V. Šrámek², I. Novák²

¹ 3. klinika infekčních a tropických nemocí 1. LF UK, Praha, přednosta doc. MUDr. A. Lobovská, CSc.

Elimination methods can improve the prognosis of critically ill patients in sepsis. With respect to that, higher activation of monocytes duringplasmapheresis could possibly play a role (increase of HLA-DR+ monocytes in peripheral blood). We observed a decrease of T lymphocyte activationin 19 patients after 24 hours of continuous veno-venous hemofiltration - CVVH (p < 0,01). On the third day of CVVH this activation returned to thelevels before initiating of the elimination method. Trend of monocyte activation followed the same course; however, it did not reach statisticalsignificance. The observed changes in the activation direct an attention to possible immunomodulatory effects of this elimination method.

Keywords: CVVH; sepsis; HLA-DR; T cells; monocytes; critically ill

Published: December 1, 2000  Show citation