Anest. intenziv. Med. 2010;21(6):337-341

Septic shock in fatal pneumonia caused by Staphylococcus aureus: The significance of producing Pantone-Valentine leukocidine - case reportIntensive Care Medicine - Original Paper

Beneš Jiří1,*, Myslivec Ondřej2, Laštíková Jarmila3, Gabrielová Alice4, Petráš Petr5, Pantůček Roman6
1 Klinika infekčních nemocí 3. LF UK, FN Na Bulovce, Praha
2 1. interní oddělení FN Na Bulovce, Praha
3 Patologicko-anatomické oddělení FN Na Bulovce, Praha
4 Oddělení klinické mikrobiologie FN Na Bulovce, Praha
5 Národní referenční laboratoř pro stafylokoky, Státní zdravotní ústav, Praha
6 Ústav experimentální biologie, Přírodovědecká fakulta MU, Brno

Necrotizing pneumonia caused by Staphylococcus aureus producing Pantone-Valentine leukocidin (PVL) is a rare but life-threatening disease. Early diagnosis of staphylococcal etiology is necessary for successful treatment. Linezolid is the first choice antibiotic that should be preferred to beta-lactams and vancomycin in this indication.
We report a case of 29-year-old man who was admitted for severe septic shock and incipient pneumonia and died 8 hours after admission despite intensive care. PVL-producing Staphylococcus aureus was isolated from the blood cultures.

Keywords: sepsis; pneumonia; Staphylococcus aureus; Pantone-Valentine leukocidin

Received: August 3, 2010; Accepted: September 21, 2010; Published: December 1, 2010  Show citation

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Beneš J, Myslivec O, Laštíková J, Gabrielová A, Petráš P, Pantůček R. Septic shock in fatal pneumonia caused by Staphylococcus aureus: The significance of producing Pantone-Valentine leukocidine - case report. Anest. intenziv. Med. 2010;21(6):337-341.
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    References

    1. Dellinger, R. P., Levy, M. M., Carlet, J. M. et al. Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit. Care Med., 2008, 36, 1, p. 296-327. Go to original source... Go to PubMed...
    2. Kolek, V. et al. Standard léčebného plánu: Diagnostika a léčba komunitně získané pneumonie dospělých. Doporučený postup České pneumologické a ftizeologické společnosti. Dostupné na www: http://www.pneumologie.cz/odborne/doc/Pneumonie%20standard%20RESP2%202007.pdf
    3. Petráš, P., Ježek, P., Machová, I. et al. Další smrtelný případ pneumonie vyvolaný kmenem Staphylococus aureus s produkcí Pantonova-Valentinova leukocidinu. Zprávy EM (SZÚ Praha), 2008, 18, 1, p. 15-17. Go to original source...
    4. Ježek, P., Bílina, P., Petráš, P. Fatální pneumonie vyvolaná kmenem Staphylococcus aureus produkujícím Pantonův-Valentinův leukocidin. Antiinfect News, 2010, 1, 1, p. 10-12.
    5. Heinige, P., Dedek, V., Fajt, M. et al. Nekrotizující pneumonie kojence s fatálním průběhem, způsobená PVL pozitivním zlatým stafylokokem. Pediatr. Prax., 2009, 10, 5, p. 326-328.
    6. Petráš, P., Rumlerová, M., Machová, I. et al. Letální abscedující pneumonie vyvolaná kmenem Staphylococcus aureus oxacilin rezistentním s produkcí Pantonova-Valentinova leukocidinu. Prakt. Lék., 2007, 88, 4, p. 236-239.
    7. Que, Y. A., Morellion, P. Staphylococcus aureus (including staphylococcal toxic shock). In Mandell, G. L., Bennett, J. E., Dolin, R. (eds) Principles and Practice of Infectious Diseases. 7th ed. Philadelphia: Churchill Livingstone, 2009, p. 2543-2578. Go to original source...
    8. Rojo, P., Barrios, M., Palacios, A. et al. Community-associated Staphylococcus aureus infections in children. Expert Rev. Anti. Infect. Ther., 2010, 8, 5, p. 541-554. Go to original source... Go to PubMed...
    9. Stein, G. E., Wells, E. M. The importance of tissue penetration in archieving successful antimicrobial treatment of nosocomial pneumonia and complicated skin and soft-tissue infections caused by methicillin-resistant Staphylococcus aureus: vancomycin and linezolid. Curr. Med. Res. Opin., 2010, 26, 3, p. 571-588. Go to original source... Go to PubMed...
    10. Yanagihara, K., Kihara, R., Araki, N. et al. Efficacy of linezolid against Panton-Valentine leucocidin (PVL-positive methicillin-resistant Staphylococcus aureus (MRSA) in a mouse model of haematogenous pulmonary infection. Int. J. Antimicrob. Agents, 2009, 34, 5, p. 477-481. Go to original source... Go to PubMed...
    11. Rouzic, N., Janvier, F., Libert, N. et al. Prompt and succesful toxin-targeting treatment of three patients with necrotizing pneumonia due to Staphylococcus aureus strains carrying the Panton-Valentine leucocidin genes. J. Clin. Microbiol., 2010, 48, 5, p. 1952-1955. Go to original source... Go to PubMed...
    12. Singh, S. R., Bacon, A. E., Young, D. C., Couch, K. A. In vitro 24-hour time-kill studies of vancomycin and linezolid in combination versus methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother., 2009, 53, 10, p. 4495-4497. Go to original source... Go to PubMed...
    13. Zyvoxid. Souhrn informací o přípravku (SPC).
    14. http://www.xalatan.cz/files/spc/pfizer/Zyvoxid/Zyvoxid_SPC_25jun09.pdf
    15. Gauduchon, V., Cozon, G., Vandenesch, F. et al. Neutralization of Staphylococcus aureus Panton-Valentine leukocidin by intravenous immunoglobulin in vitro. J. Infect. Dis., 2004, 189, 2, p. 346-353. Go to original source... Go to PubMed...
    16. Morgan, M. S. Diagnosis and treatment of Panton-Valentine leukocidin (PVL)-associated staphylococcal pneumonia. Int. J. Antimicrob. Agents, 2007, 30, 4, p. 289-296. Go to original source... Go to PubMed...
    17. Napolitano, L. M., Brunsvold, M. E., Reddy, R. C., Hyzy, R. C. Community-acquired methicillin-resistant Staphylococcus aureus pneumonia and ARDS. Chest, 2009, 136, 5, p. 1407-1412. Go to original source... Go to PubMed...

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