Anest. intenziv. Med. 1999;10(1):33-35

Lymphocytic activation in critically ill septic patients during CVVHDArticles

M. Holub¹, M. Kolář¹, M. Helcl², P. Pudil³

¹ III. klinika infekčních a tropických nemocí 1. LF UK, přednosta doc. MUDr. A. Lobovská, CSc.

² Infekční klinika FN Bulovka, primář MUDr. Hana Roháčová

³ Ústav teorie informace a automatizace AV ČR, ředitel prof. ing. Vladimír Kučera, DrSc.

In 10 critically ill septic patients treated with continuous veno-venous hemodiafiltration (CVVHD), we investigated lymphocytic activation moleculesHLA-DR. The control group consisted of 35 septic patients not treated with CVVHD. The average expression of HLA-DR molecules in critically illpatients before introducing hemodiafiltration was significantly lower than in the control group (p = 0,0394). 24 hours after introducing CVVHD, thevalues of expression were significantly higher than before aplying the method (p = 0,0034). 3 days after discontinuing CVVHD the expression stayedsignificantly increased when compared to the values obtained before using the method (p = 0,0024).During CVVHD an activation of cellular immunity was observed. The activation in critically ill septic patients is significantly lower when comparedto septic patients, that do not require intensive care.

Keywords: hemodiafiltration; HLA-DR; sepsis; lymphocytes

Published: February 1, 1999  Show citation