Anest. intenziv. Med. 2026;37(2):111-114 | DOI: 10.36290/aim.2026.020

Propofol - nové poznatky k fyziologii účinku a metabolické souvislostiClinical physiology

Skříšovská T.1, 2, Astapenko D.3-7, Černý V.4, 6-9
1 Klinika dětské anesteziologie a resuscitace, Fakultní nemocnice Brno a Lékařská fakulta Masarykovy univerzity Brno, Česká republika
2 Ústav simulační medicíny, Lékařská fakulta Masarykovy univerzity Brno, Česká republika
3 Klinika anesteziologie, resuscitace a intenzivní medicíny, Fakultní nemocnice Hradec Králové, Česká republika
4 Lékařská fakulta v Hradci Králové, Univerzita Karlova, Česká republika
5 Vojenská lékařská fakulta, Univerzita obrany v Brně, Česká republika
6 Fakulta zdravotnických studií, Technická univerzita v Liberci, Česká republika
7 Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
8 Klinika anesteziologie, perioperační a intenzivní medicíny, Univerzita J. E. Purkyně v Ústí nad Labem, Masarykova nemocnice v Ústí nad Labem, Česká republika
9 Klinika anesteziologie a resuscitace, Fakultní nemocnice Královské Vinohrady, Univerzita Karlova v Praze, 3. lékařská fakulta Univerzity Karlovy, Česká republika

Received: June 2, 2026; Revised: June 2, 2026; Accepted: June 3, 2026; Prepublished online: June 12, 2026; Published: July 10, 2026  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Skříšovská T, Astapenko D, Černý V. Propofol - nové poznatky k fyziologii účinku a metabolické souvislosti. Anest. intenziv. Med. 2026;37(2):111-114. doi: 10.36290/aim.2026.020.
Download citation

References

  1. Trapani G, Altomare C, Sanna E, Biggio G, Liso G. Propofol in anesthesia: mechanism of action, structure-activity relationships, and drug delivery. Curr Med Chem. 2000;7(2):249-271. doi: 10.2174/0929867003375335. Go to original source... Go to PubMed...
  2. Sun NCH, Wong AYC, Irwin MG. A comparison of pain on intravenous injection between two preparations of propofol. Anesth Analg. 2005;101(3):675-678. doi: 10.1213/01.ANE.0000157564.91910.04. Go to original source... Go to PubMed...
  3. Liljeroth E, Åkeson J. Less local pain on intravenous infusion of a new propofol emulsion. Acta Anaesthesiol Scand. 2005;49(2):248-251. doi: 10.1111/j.1399-6576.2004.00573.x. Go to original source... Go to PubMed...
  4. Meidert AS, Rucz P, Angster J, Esser J, Miklós A, Schelling G. Photoacoustic detection of propofol in breath gas for monitoring depth of anaesthesia: from bench to bedside. Br J Anaesth. 2025;135(5):1203-1211. doi: 10.1016/j.bja.2025.07.080. Go to original source...
  5. Kuck K, Hornuss C. Propofol is in the air: can exhaled gas monitoring illuminate intravenous dosing? Br J Anaesth. 2025;135(5):1144-1146. doi: 10.1016/j.bja.2025.08.006. Go to original source... Go to PubMed...
  6. Bleeker C, Vree T, Lagerwerf A, Willems-van Bree E. Recovery and long-term renal excretion of propofol, its glucuronide, and two di-isopropylquinol glucuronides after propofol infusion during surgery. Br J Anaesth. 2008;101(2):207-212. doi: 10.1093/bja/aen134. Go to original source...
  7. Lasica A, Cortesi C, Milani GP, Bianchetti MG, Schera FM, Camozzi P, et al. Propofol-associated urine discoloration: systematic literature review. Pharmacology. 2023;108(5):415-422. doi: 10.1159/000533327. Go to original source... Go to PubMed...
  8. Astapenko D, Černý V. Barva moči z pohledu klinické fyziologie. Anest intenziv Med. 2022;33(3-4):177-178. doi: 10.36290/aim.2022.031. Go to original source...
  9. Sears S, Hewett SJ. Influence of glutamate and GABA transport on brain excitatory/inhibitory balance. Exp Biol Med (Maywood). 2021;246(9):1069-1083. doi: 10.1177/1535370221989263. Go to original source...
  10. Jiang J, Jiao Y, Gao PO, Yin W, Zhou W, Zhang Y, et al. Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAA receptor and GABAergic neuron in corresponding nuclei. Acta Biochim Biophys Sin. 2021;53(8):1076-1087. doi: 10.1093/abbs/gmab084. Go to original source... Go to PubMed...
  11. Huang Z, Mashour GA, Hudetz AG. Propofol disrupts the functional core-matrix architecture of the thalamus in humans. figshare [Internet]. 2024 [cited 2026 May 25]. doi: 10.6084/M9.FIGSHARE.25927939. Go to original source...
  12. Malekmohammadi M, Price CM, Hudson AE, DiCesare JAT, Pouratian N. Propofol-induced loss of consciousness is associated with a decrease in thalamocortical connectivity in humans. Brain. 2019;142(8):2288-2302. doi: 10.1093/brain/awz169. Go to original source... Go to PubMed...
  13. Song XX, Yu BW. Anesthetic effects of propofol in the healthy human brain: functional imaging evidence. J Anesth. 2015;29(2):279-288. doi: 10.1007/s00540-014-1889-4. Go to original source... Go to PubMed...
  14. Gupta A, Stierer T, Zuckerman R, Sakima N, Parker SD, Fleisher LA. Comparison of recovery profile after ambulatory anesthesia with propofol, isoflurane, sevoflurane and desflurane: a systematic review. Anesth Analg. 2004;98(3):632-641. doi: 10.1213/01.ANE.0000103187.70627.57. Go to original source... Go to PubMed...
  15. Tramèr M, Moore A, McQuay H. Meta-analytic comparison of prophylactic antiemetic efficacy for postoperative nausea and vomiting: propofol anaesthesia vs omitting nitrous oxide vs total i.v. anaesthesia with propofol. Br J Anaesth. 1997;78(3):256-259. doi: 10.1093/bja/78.3.256. Go to original source...
  16. Kampo S, Afful AP, Mohammed S, Ntim M, Buunaaim ADB, Anabah TW. Sub-hypnotic dose of propofol as antiemetic prophylaxis attenuates intrathecal morphine-induced postoperative nausea and vomiting, and pruritus in parturient undergoing cesarean section: a randomized control trial. BMC Anesthesiol. 2019;19(1):177. doi: 10.1186/s12871-019-0847-y. Go to original source... Go to PubMed...
  17. Krajčová A, Waldauf P, Anděl M, Duška F. Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports. Crit Care. 2015;19:398. doi: 10.1186/s13054-015-1112-5. Go to original source... Go to PubMed...
  18. Hemphill S, McMenamin L, Bellamy MC, Hopkins PM. Propofol infusion syndrome: a structured literature review and analysis of published case reports. Br J Anaesth. 2019;122(4):448-459. doi: 10.1016/j.bja.2018.12.025. Go to original source... Go to PubMed...
  19. Mirrakhimov AE, Voore P, Halytskyy O, Khan M, Ali AM. Propofol infusion syndrome in adults: a clinical update. Crit Care Res Pract. 2015;2015:260385. doi: 10.1155/2015/260385. Go to original source... Go to PubMed...
  20. Stovell M, Smith S, Udberg M, Loh W, Nair P. Pre-PRIS? Prospective monitoring for early markers of propofol infusion syndrome. Crit Care. 2013;17(Suppl 2):P391. doi: 10.1186/cc12329. Go to original source...
  21. Khodadadi M, Mohsenzadeh M, Eghbalian M, Pouladkhay F. Biochemical and pharmacological characterization of propofol infusion syndrome risk markers following high-dose propofol. Sci Rep. 2026;16:2038. doi: 10.1038/s41598-025-31739-y. Go to original source... Go to PubMed...
  22. Djahel C, Marois C, Cosme L, Hayatou Z, Braham Ghedira N, Calonge Q, et al. Propofol-related biological alterations and incidence of propofol infusion syndrome in status epilepticus: a 10-year cohort study. Front Neurol. 2026;16:1753979. doi: 10.3389/fneur.2025.1753979. Go to original source... Go to PubMed...




Anesteziologie a intenzivní medicína

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.