Anest. intenziv. Med. 2025;36(5):377-383 | DOI: 10.36290/aim.2025.066

Year 2025 in review - Acute respiratory failure and lung supportReview Article

Máca J.1, 2, Burša F.1, 2, Sklienka P.1, 2
1 Klinika anesteziologie, resuscitace a intenzivní medicíny, Fakultní nemocnice Ostrava a Lékařská fakulta, Ostravská Univerzita v Ostravě
2 Ústav fyziologie a patofyziologie, Lékařská fakulta, Ostravská univerzita v Ostravě

Several original papers on the topic of acute respiratory failure (ARF) were published in 2025, including studies that support respiratory functions through mechanical ventilation (MV) or the veno-venous form of extracorporeal membrane oxygenation (VV ECMO). The aim of this text is to introduce readers to selected works that, according to the authors, may be of interest not only to researchers in the field but also to physicians in clinical practice. The review article is divided into several sections; the first includes randomized papers and post-hoc analysis of papers already published. The second part is devoted to large prospective observational studies and works based on registries. The final section addresses diagnostic and prognostic studies. The article search was carried out using an AI client (SciSpace). A prompt requesting the presence of human medicine articles dealing with ARF in critical care, published in high-impact journals in 2025 to date, was used. Review articles were excluded. AI ranked the searched database according to relevance from the perspective of the main topic. The next step involved standardizing the selection and finally describing the selected literature. Fifteen full-text articles were selected as sources for the paper from the original 100 results obtained.

Keywords: acute respiratory failure, intensive care medicine, artificial pulmonary ventilation, mechanical ventilation, extracorporeal membrane oxygenation, non­‑invasive ventilation, prone position.

Received: November 5, 2025; Revised: November 5, 2025; Accepted: December 16, 2025; Prepublished online: December 21, 2025; Published: December 22, 2025  Show citation

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Máca J, Burša F, Sklienka P. Year 2025 in review - Acute respiratory failure and lung support. Anest. intenziv. Med. 2025;36(5):377-383. doi: 10.36290/aim.2025.066.
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References

  1. Maia IS, Kawano-Dourado L, Tramujas L, de Oliveira NE, Souza RN, Signorini DF, et al. High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure: The RENOVATE Randomized Clinical Trial. JAMA. 2025 Mar 11;333(10):875-890. doi: 10.1001/jama.2024.26244. PMID: 39657981; PMCID: PMC11897836. Go to original source... Go to PubMed...
  2. Monti G, Cabrini L, Kotani Y, Brusasco C, Kadralinova A, Giardina G, et al. NAVIGATE Study Group. Early noninvasive ventilation in general wards for acute respiratory failure: an international, multicentre, open-label, randomised trial. Br J Anaesth. 2025 Feb;134(2):382-391. doi: 10.1016/j.bja.2024.11.023. Epub 2025 Jan 2. PMID: 39753402. Go to original source... Go to PubMed...
  3. Krenn K, Kraft F, Urban M, Ullrich R, Grasmuk-Siegl E, Gelbenegger G, et al. Efficacy of solnatide to treat pulmonary permeability edema in SARS-CoV-2 positive patients with moderate to severe ARDS: A randomized controlled pilot-trial. Anaesth Crit Care Pain Med. 2025 May;44(3):101520. doi: 10.1016/j.accpm.2025.101520. Epub 2025 Apr 23. Go to original source... Go to PubMed...
  4. Zhao Y, Zhang S, Liu C, Wang X. Individualized Lung-Protective Ventilation Strategy Based on Esophageal Pressure Monitoring in Patients With ARDS Associated With Severe Acute Pancreatitis-A Randomized Controlled Trial. World J Surg. 2025 Sep;49(9):2361-2373. doi: 10.1002/wjs.12676. Epub 2025 Jul 25. PMID: 40709724; PMCID: PMC12435606. Go to original source... Go to PubMed...
  5. De Jong A, Huguet H, Bignon A, Stephan F, Godet T, Collet L, et al. Noninvasive ventilation in postoperative critically ill patients with morbid obesity: secondary analysis of the EXTUBOBESE multicentre randomised clinical trial. Br J of Anaest. 2025;135(5):1477-1485. Go to original source... Go to PubMed...
  6. Peetermans M, Bohyn A, Meersseman P, Wilmer A, Wauters J, Meyns B, et al. Outcomes of transplant recipients on ECMO for COVID-19 respiratory failure: an ELSO registry study. Crit Care. 2025 Sep 25;29(1):404. doi: 10.1186/s13054-025-05636-9. PMID: 40999467; PMCID: PMC12465718. Go to original source... Go to PubMed...
  7. Tripcovici M, Sharma A, Clopton BJ, Kurtz D, Soubani AO. Epidemiology and outcomes of hospitalized patients with lung cancer and acute respiratory failure: National inpatient database analysis. Hematol Oncol Stem Cell Ther. 2025 Sep 12. doi: 10.4103/hemoncstem.HEMONCSTEM-D-25-00025. Epub ahead of print. PMID: 40936468. Go to original source... Go to PubMed...
  8. Olmos M, Fuentes N, Busico M, Gallardo A, Vitali A, Costa ELV, et al. Argentine Collaborative Group on High Flow, Prone Positioning. Effectiveness of bundle of care on tolerance of awake-prone positioning in patients with acute respiratory failure. A multicenter observational study. Intensive Care Med. 2025 Feb;51(2):332-341. doi: 10.1007/s00134-025-07804-5. Epub 2025 Feb 17. PMID: 39961842. Go to original source... Go to PubMed...
  9. Strickler NS, Hofmaenner DA, Schuepbach RA, Scheier TC, Buehler PK, Takala J, et al. Use of carbon dioxide production to detect bacterial superinfections in mechanically ventilated patients with acute respiratory distress syndrome: an exploratory prospective cohort study. BMJ Open Respir Res. 2025 Aug 28;12(1):e002760. doi: 10.1136/bmjresp-2024-002760. PMID: 40876958; PMCID: PMC12410624. Go to original source... Go to PubMed...
  10. Sasaki A, Nakajima M, Shinozaki T, Sasabuchi Y, Ohbe H, Kaszynski RH, et al. Association between early administration of mucoactive agents and in-hospital mortality in patients with pneumonia requiring mechanical ventilation: a nationwide cohort study. J Intensive Care. 2025;13:57. https://doi.org/10.1186/s40560-025-00826-7. Go to original source... Go to PubMed...
  11. Labar AS, Ulrich BC, Lovelace TC, Bain WG, Shah FA, White EB, et al. Plasma Levels of Soluble ST2 Reflect Extrapulmonary Organ Dysfunction and Predict Outcomes in Acute Respiratory Failure. Critical Care Medicine. 2025;53(8):e1567-e1580. doi: 10.1097/CCM.0000000000006716. Go to original source... Go to PubMed...
  12. Costa Monteiro AC, Pickering H, Sarma A, Taylor CS, Jenkins MM, Hsu F-M, et al. Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS. Crit Care 2025; 29:432. doi: https://doi.org/10.1186/s13054-025-05596-0. Go to original source... Go to PubMed...
  13. Chen J, Lv J, Liu M, Dai X, Deng W. Between endothelial activation and stress index (EASIX) and mortality in acute respiratory distress syndrome (ARDS) patients: a multicenter retrospective study. Front Physiol. 2025;26(16):1570988. doi: 10.3389/fphys.2025.1570988. PMID: 41078378; PMCID: PMC12511030. Go to original source... Go to PubMed...
  14. Liu N, Zhang Q, Wang H, Ding R, Geng X, Wang L, et al. The effect of target transpulmonary driving pressure values on mortality in ARDS patients: A retrospective study based on the MIMIC-IV database. PLoS One. 2025 Jun 18;20(6):e0326060. doi: 10.1371/journal.pone.0326060. PMID: 40531833; PMCID: PMC12176163. Go to original source... Go to PubMed...
  15. Hong Q, Yang X, Yang H, Zhou X, Tang J, Wen Z. Prognostic impact of angiotensin-converting enzyme inhibitors and dexmedetomidine in acute respiratory distress syndrome: a MIMIC-IV-based retrospective cohort analysis. Front Med (Lausanne). 2025 Aug 18;12:1601565. doi: 10.3389/fmed.2025.1601565. PMID: 40901505; PMCID: PMC12401063. Go to original source... Go to PubMed...




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