Anest. intenziv. Med. 2025;36(5):357-359 | DOI: 10.36290/aim.2025.068

Year 2025 in review - Chronic pain therapyReview Article

Fricová J.
Klinika anesteziologie, resuscitace a intenzivní medicíny, Centrum pro léčbu bolesti 1. lékařské fakulty Univerzity Karlovy a Všeobecné fakultní nemocnice, Praha

Year 2025 introduces major advancements in neurobiological concepts of chronic pain, particularly through the identification of dopaminergic modulation as a novel therapeutic framework. This article summarises key developments in international initiatives, pharmacotherapy, non‑pharmacological interventions, clinical guidelines and neurobiological mechanisms of pain. It follows the structure and style of the 2024 overview and highlights how new insights are shaping current and future pain management.

Keywords: chronic pain, dopaminergic modulation, nociplastic pain, neuromodulation, tDCS, rTMS, PRT, pharmacotherapy.

Received: December 17, 2025; Accepted: December 17, 2025; Published: December 22, 2025  Show citation

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Fricová J. Year 2025 in review - Chronic pain therapy. Anest. intenziv. Med. 2025;36(5):357-359. doi: 10.36290/aim.2025.068.
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    References

    1. International Association for the Study of Pain (IASP). Global Year for Sex and Gender Differences in Pain. IASP; 2024.
    2. European Pain Federation (EFIC). European Pain Awareness Campaigns and Policy Statements. EFIC; 2024.
    3. U.S. Food and Drug Administration (FDA). Cannabidiol (CBD) - Regulation, Safety and Efficacy in Pain. FDA Safety Communication; 2024-2025.
    4. American Academy of Pediatrics. Clinical Practice Guideline for Opioid Prescribing in Children and Adolescents With Acute Pain. AAP; 2024.
    5. Geha P, Sulovari A, Freeman R, Gewandter JS. Dopaminergic modulation: revisiting a promising novel pathway for pharmacologic treatment of chronic pain. Pain. 2025 Oct 1;166(10):2213-2219. doi: 10.1097/j.pain.0000000000003598. Go to original source... Go to PubMed...
    6. Neuromodulation Research Consortium. Non‑invasive brain stimulation (tDCS, rTMS) in nociplastic and musculoskeletal pain: multicentre clinical data 2024-2025.
    7. Psychological Interventions Working Group. Pain Reprocessing Therapy and Personal Danger Signal Reprocessing in chronic pain: outcome evidence 2024-2025.
    8. Nav1.7 Genetic Variants and Chronic Pain: Clinical Implications. Expert Consensus Report; 2024-2025.

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