Anest. intenziv. Med. 2025;36(3):203-210 | DOI: 10.36290/aim.2025.042
Spinal anaesthesia and maternal hypotension: basic pathophysiology and an opinion of an interdisciplinary working group on its managementShort Communication
- 1 Klinika anesteziologie, resuscitace a intenzivní medicíny 1. lékařské fakulty Univerzity Karlovy a Všeobecné fakultní nemocnice v Praze
- 2 Ústav pro péči o matku a dítě a 3. lékařská fakulta Univerzity Karlovy, Praha
- 3 Gynekologicko‑porodnické oddělení Krajské zdravotní, a. s. - Nemocnice Most
- 4 Klinika gynekologie, porodnictví a neonatologie 1. lékařské fakulty Univerzity Karlovy a Všeobecné fakultní nemocnice v Praze
- 5 II. anesteziologicko‑resuscitační oddělení Fakultní nemocnice Brno
- 6 Klinika dětské anesteziologie a resuscitace Fakultní nemocnice Brno a Lékařská fakulta Masarykovy univerzity
- 7 Ústav simulační medicíny Lékařské fakulty Masarykovy univerzity, Brno
Hypotension after spinal anaesthesia occurs in most parturients undergoing caesarean section. The text describes the mechanism of hypotension, summarises the current evidence for treating this complication, and presents the consensus opinion of an interdisciplinary panel on its management. The text has been endorsed by the Czech Society of Anaesthesiology, Resuscitation, and Intensive Care Medicine, the Czech Gynaecological and Obstetric Society, and the Czech Neonatological Society.
Keywords: hypotension, spinal anaesthesia, caesarean section, arteriolar vasodilation, systemic vascular resistance, vasopressors, phenylephrine, ephedrine, prevention.
Received: March 25, 2025; Revised: September 10, 2025; Accepted: September 10, 2025; Published: September 30, 2025 Show citation
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References
- Fitzgerald JP, Fedoruk KA, Jadin SM, Carvalho B, Halpern SH. Prevention of hypotension after spinal anaesthesia for caesarean section: a systematic review and network meta-analysis of randomised controlled trials. Anaesthesia 2020, 75(1):109-121.
Go to original source...
- Patel S, Ninave S. Postspinal Anaesthesia Hypotension in Caesarean Delivery: A Narrative Review. Cureus 2024, 16(4):e59232.
Go to original source...
- Kinsella SM, Carvalho B, Dyer RA, Fernando R, McDonnell N, Mercier FJ, et al. International consensus statement on the management of hypotension with vasopressors during caesarean section under spinal anaesthesia. Anaesthesia 2018, 73(1):71-92.
Go to original source...
- Vasile F, La Via L, Murabito P, Tigano S, Merola F, Nicosia T, et al. Non-Invasive Monitoring during Caesarean Delivery: Prevalence of Hypotension and Impact on the Newborn. J Clin Med 2023, 12(23).
Go to original source...
- Park H-S, Choi W-J. Use of vasopressors to manage spinal anaesthesia-induced hypotension during cesarean delivery. Anesth Pain Med 2024, 19(2):85-93.
Go to original source...
- van Dyk D, Dyer RA, Bishop DG. Spinal hypotension in obstetrics: Context-sensitive prevention and management. Best Practice & Research Clinical Anaesthesiology 2022, 36(1):69-82.
Go to original source...
- Bower JR, Kinsella SM. Preventing and treating hypotension during spinal anaesthesia for caesarean section. BJA Education 2020, 20(11):360-361.
Go to original source...
- Pirenne V, Dewinter G, Van de Velde M. Spinal anaesthesia in obstetrics. Best Pract Res Clin Anaesthesiol 2023, 37(2):101-108.
Go to original source...
- Yu C, Gu J, Liao Z, Feng S. Prediction of spinal anesthesia-induced hypotension during elective cesarean section: a systematic review of prospective observational studies. Int J Obstet Anesth 2021, 47:103175.
Go to original source...
- Singh PM, Singh NP, Reschke M, Ngan Kee WD, Palanisamy A, Monks DT. Vasopressor drugs for the prevention and treatment of hypotension during neuraxial anaesthesia for Caesarean delivery: a Bayesian network meta-analysis of fetal and maternal outcomes. Br J Anaesth 2020, 124(3):e95-e107.
Go to original source...
- Heesen M, Hilber N, Rijs K, Rossaint R, Girard T, Mercier FJ, et al. A systematic review of phenylephrine vs. noradrenaline for the management of hypotension associated with neuraxial anaesthesia in women undergoing caesarean section. Anaesthesia 2020, 75(6):800-808.
Go to original source...
- Park HS, Choi WJ. Use of vasopressors to manage spinal anesthesia-induced hypotension during cesarean delivery. Anesth Pain Med (Seoul) 2024, 19(2):85-93.
Go to original source...
- Chao E, Sun HL, Huang SW, Liao JH, Ma PL, Chen HC. Metaraminol use during spinal anaesthesia for caesarean section: a meta-analysis of randomised controlled trials. International Journal of Obstetric Anesthesia 2019, 39:42-50.
Go to original source...
- Lee AJ, Landau R, Mattingly JL, Meenan MM, Corradini B, Wang S, et al. Left Lateral Table Tilt for Elective Cesarean Delivery under Spinal Anesthesia Has No Effect on Neonatal Acid-Base Status: A Randomized Controlled Trial. Anesthesiology 2017, 127(2):241-249.
Go to original source...
- Gagné M-P, Richebé P, Loubert C, Drolet P, Gobert Q, Denault A, et al. Ultrasound evaluation of inferior vena cava compression in tilted and supine term parturients. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 2021, 68(10):1507-1513.
Go to original source...
- Higuchi H, Takagi S, Zhang K, Furui I, Ozaki M. Effect of lateral tilt angle on the volume of the abdominal aorta and inferior vena cava in pregnant and nonpregnant women determined by magnetic resonance imaging. Anesthesiology 2015, 122(2):286-293.
Go to original source...
- Wen C, Xiang YY, Pang QY, Liu HL. Effects of neuraxial anesthesia in sitting and lateral positions on maternal hemodynamics in cesarean section: A systematic review and meta-analysis. PLoS One 2024, 19(5):e0303256.
Go to original source...
- Chooi C, Cox JJ, Lumb RS, Middleton P, Chemali M, Emmett RS, et al. Techniques for preventing hypotension during spinal anaesthesia for caesarean section. Cochrane Database Syst Rev 2020, 7(7):Cd002251.
Go to original source...
- Massoth C, Töpel L, Wenk M. Hypotension after spinal anesthesia for cesarean section: how to approach the iatrogenic sympathectomy. Curr Opin Anaesthesiol 2020, 33(3):291-298.
Go to original source...