Anest. intenziv. Med. 2023;34(1):15-22 | DOI: 10.36290/aim.2023.006

Ischaemia­‑reperfusion injury in vascular surgery - narrative reviewReview Article

Lukeš M.^{1, 2}, Růžek L.^{1, 2, 3}, Čundrle I.^{1, 2, 3}

¹ Anesteziologicko-resuscitační klinika, Fakultní nemocnice u sv. Anny v Brně

² Lékařská fakulta Masarykovy univerzity v Brně

³ Mezinárodní centrum klinického výzkumu, Fakultní nemocnice u sv. Anny v Brně

Vascular surgery patients are exposed to the risk of secondary trauma, which arises on the basis of pathological changes caused first by ischemia and then by reperfusion. Ischemia-reperfusion syndrome due to oxidative stress and increased cell death contributes significantly to the high perioperative morbidity and mortality of these patients. In an attempt to reduce the negative impact of these processes, a number of measures have been developed, including the concept of remote ischemic preconditioning. Based on the analogy between the pathophysiology of ischemic preconditioning and sleep disordered breathing, we can hypothesize a smaller impact of ischemia-reperfusion changes in patients with obstructive sleep apnea.

Keywords: ischaemia­‑reperfusion injury, remote ischaemic preconditioning, vascular surgery.

Received: October 11, 2022; Revised: February 24, 2023; Accepted: March 13, 2023; Published: April 25, 2023  Show citation