Anest. intenziv. Med. 2017;28(5):305-308

Succesful use of methylene blue in a patient with refractory shock on veno-arterial extracorporeal membrane oxygenationIntesive Care Medicine - Case Report

M. Pořízka1,*, J. Kunstýř1, P. Kopecký1, M. Balík1
1 Klinika anesteziologie, resuscitace a intenzivní medicíny, Všeobecná fakultní nemocnice v Praze, 1. lékařská fakulta, Univerzita Karlova

Refractory circulatory shock is associated with excessive mortality in critically ill patients. Non-adrenergic vasopressors, including methylene blue, are often considered as an adjuvant therapy to the ordinary vasopressor treatment. In this case report we present a case of successful use of methylene blue reversing refractory septic shock in a patient on veno-arterial extracorporeal membrane oxygenation due to septic cardiomyopathy.

Keywords: methylene blue; distributive shock; refractory vasoplegia; cardiomyopathy; extracorporeal membrane oxygenation

Received: March 20, 2017; Accepted: June 15, 2017; Published: October 1, 2017  Show citation

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Pořízka M, Kunstýř J, Kopecký P, Balík M. Succesful use of methylene blue in a patient with refractory shock on veno-arterial extracorporeal membrane oxygenation. Anest. intenziv. Med. 2017;28(5):305-308.
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References

  1. De Backer D, Biston P, Devriendt J, Madl C, Chochrad D, Aldecoa C, Brasseur A, Defrance P, Gottignies P, Vincent JL. SOAP II Investigators. Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med. 2010;362:779-789. doi: 10.1056/NEJMoa0907118. Go to original source... Go to PubMed...
  2. Bassi E, Park M, Azevedo LC. Therapeutic strategies for high-dose vasopressor-dependent shock. Crit Care Res Pract. 2013;2013:654-708. doi: 10.1155/2013/654708. Go to original source... Go to PubMed...
  3. Jenkins CR, Gomersall CD, Leung P, Joynt GM. Outcome of patients receiving high dose vasopressor therapy: a retrospective cohort study. Anaesth Intensive Care. 2009;37:286-9. Go to original source... Go to PubMed...
  4. Belletti A, Musu M, Silvetti S, Saleh O, Pasin L, Monaco F, Hajjar LA, Fominskiy E, Finco G, Zangrillo A, Landoni G. Non-Adrenergic Vasopressors in Patients with or at Risk for Vasodilatory Shock. A Systematic Review and Meta-Analysis of Randomized Trials. PLoS One. 2015;10:e0142605. doi: 10.1371/journal.pone.0142605. Go to original source... Go to PubMed...
  5. Avni T, Lador A, Lev S, Leibovici L, Paul M, Grossman A. Vasopressors for the Treatment of Septic Shock: Systematic Review and Meta-Analysis. PLoS One.;108:e0129305. doi: 10.1371/journal.pone.0129305. Go to original source...
  6. Jang DH, Nelson LS, Hoffman RS. Methylene blue for distributive shock: a potential new use of an old antidote. J Med Toxicol. 2013;9:242-9. doi: 10.1007/s13181-013-0298-7. Go to original source... Go to PubMed...
  7. Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Gerlach H, Moreno R, Carlet J, Le Gall JR, Payen D. Sepsis Occurrence in Acutely Ill Patients Investigators. Sepsis in European intensive care units: results of the SOAP study. Crit Care Med. 2006;34:344-53. Go to original source... Go to PubMed...
  8. Price S, Anning PB, Mitchell JA, Evans TW. Myocardial dysfunction in sepsis: mechanisms and therapeutic implications. Eur Heart J. 1999;20:715-24. Go to original source... Go to PubMed...
  9. Huang CT, Tsai YJ, Tsai PR, Ko WJ. Extracorporeal membrane oxygenation resuscitation in adult patients with refractory septic shock. J Thorac Cardiovasc Surg. 2013;146: 1041-1046. Go to original source... Go to PubMed...




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