Anest. intenziv. Med. 2012;23(5):253-258

New role and rennaisance of branched chain aminoacids in intensive careIntesive Care Medicine - Review Article

Zadák Zdeněk*, Hyšpler Radomír, Tichá Alena
Centrum pro výzkum a vývoj, Fakultní nemocnice Hradec Králové

The branched chain amino acids valine, leucine and isoleucine are essential nutrients with more than nutritional effects. They are important mediators and structural components in proteosynthesis and they regulate hormonal functions. Leucine is a precursor in cholesterol synthesis and as such plays an important role in muscle tissue growth and in sarcopenia suppression. Older and recent data are reviewed and support wider utilization of branched chain amino acids in intensive care.

Keywords: branched chain amino acids; valine; leucine; izoleucine; sarcopenia; catabolism; beta-hydroxy beta-methylbutyrate; critical condition

Received: May 4, 2012; Accepted: June 30, 2012; Published: October 1, 2012  Show citation

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Zadák Z, Hyšpler R, Tichá A. New role and rennaisance of branched chain aminoacids in intensive care. Anest. intenziv. Med. 2012;23(5):253-258.
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    References

    1. Ozgultekin, A., Turan, G., Durmus, Y., Dincer, E., Akgun, N. Comparison of the efficacy of parenteral glutamine and branched-chain amino acid solutions given as extra supplements in parallel to the enteral nutrition in head trauma. Clin. Nutr., 2008, 3, 3, p. 211-216. Go to original source...
    2. Nissen, S., Abumrad, N. Nutritional role of the leucine metabolite beta-hydroxy beta-methylbutyrate (HMB). Nutr. Biochem., 1997, 8, 6, p. 300-311. Go to original source...
    3. Harris, R. A., Joshi, M., Jeoung, N. H. Mechanism responsible for regulation of branched-chain amino acid catabolism. Biochem. Biophys. Res. Commun., 2004, 33, 2, p. 391-396. Go to original source... Go to PubMed...
    4. Lal, H., Chugh, K. Metabolic and regulatory effects of branched chain amino acid supplementation. Nutr. Res., 1995, 15, 11, p. 1717-1733. Go to original source...
    5. Holecek, M. Three targets of branched-chain amino acid supplementation in the treatment of liver disease. Nutrition, 2012, 26, 5, p. 482-490. Go to original source... Go to PubMed...
    6. Freund, H. R., Hanani, M. The metabolic role of branched-chain amino acids. Nutrition, 2002, 18, 3, p. 287-288. Go to original source... Go to PubMed...
    7. Marchesini, G. et al. Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: A double-bind, randomized trial. Gastroenterology, 2003, 124, 7, p. 1792-1801. Go to original source... Go to PubMed...
    8. Merli, M., Nicolini, G., Angeloni, S., Riggio, O. Malnutrition is a risk factor in cirhotic patients undergoing surgery. Nutrition, 2002, 18, 17, p. 978-986. Go to original source... Go to PubMed...
    9. Kim, H. Glutamine as an imunonutrient. Yonsei med. J., 2011, 52, 6, p. 892-897. Go to original source... Go to PubMed...
    10. Leweling, H. et al. Hyperamoemia-induced depletion of glutamate and branched-chain amino acids in muscle and plasma. J. Hepatol., 1996, 25, 5, p. 756-762. Go to original source... Go to PubMed...
    11. Ijichi, Ch., Matsumura, T., Tsuji, T., Eto, Y. Branched-chain amino acids promote albumin synthesis in rat primary hepatocytes through the mTOR signal transduction system. Biochem. Biophys. Res. Commun., 2003, 303, 1, p. 59-64. Go to original source... Go to PubMed...
    12. Yoshizawa, F. New therapeutic strategy for amino acid medicine: notable functions of branched chain amino acids as biological regulators. J. Pharmacol. Sci., 2011, 118, 2, p. 149-155. Go to original source... Go to PubMed...
    13. Kim, J. S., Wilson, J. M., Lee S. R. Dietary implications on mechanism of sarcopenia: roles of protein, amino acids and antioxidants. J. Nurl. Biochem., 2012, 21, 1, p. 1-13. Go to original source... Go to PubMed...
    14. Nicastro, H. et al. Does branched-chain amino acids supplementation modulate skeletal muscle remodeling through inflammation modulation? Possible mechanisms of Action. J. Nutr. Metab., 2012, 2012, 1, p. 1-10. Go to original source... Go to PubMed...
    15. Chanda, S., Mehendale, H. Role of nutrition in the survival after hepatotoxic injury. Toxicology, 1996, 111, 1-3, p. 163-178. Go to original source... Go to PubMed...
    16. Kondrup, J. Nutrition in end stage liver disease. Best Pract. Res. Clin. Gastroenterol., 2006, 20, 3, p. 547-560. Go to original source... Go to PubMed...
    17. Plauth, M. et al. ESPEN guidelines on parenteral nutrition: Hepatology. Clin. Nutr., 2009, 28, 4, p. 436-444. Go to original source... Go to PubMed...
    18. Hwang, T. L., Chiang, Ch. L., Wang, P. N. Parenteral nutrition support after bone marrow transplantation: comparison of total and partial nutrition during the early posttransplantation period. Nutrition, 2001, 17, 9, p. 773-775. Go to original source... Go to PubMed...
    19. King, P., Power, D. Branched chain amino/keto acid supplementation following severe burn injury: a preliminary report. Clin. Nutr., 1990, 9, 4, p. 226-230. Go to original source... Go to PubMed...
    20. De Bandt, J. P., Cynober, L. Therapeutic use of branched-chain amino acids in burn, trauma, and sepsis. J. Nutr., 2006, 136, 1 suppl, p. 308S-313S. Go to original source... Go to PubMed...

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