Anest. intenziv. Med. 2009;20(2):96-101

Hypocholesterolaemia on the medical intensive care unit: The process of cholesterol synthesis and absorption is altered in the acute phase of diseaseIntensive Care Medicine - Original Paper

Hrabovský Vladimír1,*, Zadák Zdeněk2, Bláha Vladimír2, Hyšpler Radomír2, Mendlová Alice1
1 Interní klinika, Fakultní nemocnice Ostrava
2 Lékařská fakulta, Univerzita Karlova, Hradec Králové

Objective:
Hypocholesterolaemia has been described as a common feature in patients with acute disease and is associated with poor prognosis. By using cholesterol synthesis (lathosterol, squalene) and absorption (sitosterol, campesterol) markers it is possible to determine the changes in both the processes of cholesterol acquisition. The aim of this study is to describe the changes of cholesterol metabolism in patients with acute medical disease.

Design:
Prospective study.
Setting:
Department of Medicine, Teaching Hospital.

Materials and methods:
The study included 60 patients with acute medical disease solely on artificial nutrition. Plasma concentrations of total cholesterol, HDL and LDL cholesterol were measured on days 0, 3 and 7. Lathosterol, squalene, sitosterol and campesterol concentrations were determined on days 3 and 7. The metabolic parameters were compared with a control group.

Results:
We detected a statistically significant decrease in total cholesterol concentration, and lower plasma levels of LDL and HDL cholesterol. A statistically significant decrease in lathosterol and campesterol plasma levels was detected. Sitosterol concentrations were lower but not significantly. The concentration of squalene was noted to be higher than in the control group.

Conclusion:
Our results show abnormalities in the cholesterol metabolism, including both arms of the cholesterol acquisition process, in patients with acute medical disease.

Keywords: lipids; cholesterol; hypocholesterolemia; non-cholesterol steroids

Received: October 6, 2008; Accepted: January 20, 2009; Published: April 1, 2009  Show citation

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Hrabovský V, Zadák Z, Bláha V, Hyšpler R, Mendlová A. Hypocholesterolaemia on the medical intensive care unit: The process of cholesterol synthesis and absorption is altered in the acute phase of disease. Anest. intenziv. Med. 2009;20(2):96-101.
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