Anest. intenziv. Med. 2007;18(2):96-102

Oxygen toxicity in the course of hyperbaric oxygenotherapyIntensive Care Medicine - Original Paper

M. Hájek
Centrum hyperbarické oxygenoterapie, Anesteziologicko-resuscitační oddělení, Městská nemocnice Ostrava

Objective:
Hyperbaric oxygen treatment is based on breathing pure oxygen under pressure higher than the ambient pressure. Signs of toxicity can occur due to the presence of oxygen and nitrogen reactive substances during exposure to high doses of oxygen.


Aim of study:
To find the incidence of oxygen toxicity in patients treated in our centre in 1994-2005.

Design:
Observational retrospective study.

Results:
4,164 patients underwent total 48,992 treatment sessions in the period studied. Thirteen cases of toxicity occurred in 7 patients. The most dramatic symptom of oxygen CNS toxicity - hyperoxia-induced seizures - were observed in 4 patients (0.008%). The relation between hyperoxia-induced seizures and treatment pressure at different time periods was analysed and compared with the results of our previous study from 1984.

Conclusion:
Hyperbaric oxygen treatment is a safe and well tolerated method with a low incidence of CNS toxicity.The incidence of hyperoxia-induced seizures presented in our paper is almost the lowest of recently published studies. No injury or permanent sequelae were observed in relation to hyperoxia-induced seizures.

Keywords: hyperbaric oxygenation; hyperoxia; toxic actions; CNS; pulmonary function; seizures

Published: April 1, 2007  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Hájek M. Oxygen toxicity in the course of hyperbaric oxygenotherapy. Anest. intenziv. Med. 2007;18(2):96-102.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Mathieu, D. 7th European Consensus Conference On Hyperbaric Medicine, Lille, 2004. Europ. J. Underwater Hyperbaric Med., 2005, 6, p. 29-38.
    2. Jain, K. K. Physical, Physiological and Biochemical Aspects of Hyperbaric Oxygenation. In Jain, K. K. (ed.) Textbook of Hyperbaric Medicine. 4th Edition, Toronto : Hogrefe and Huber Publishers 2004, p. 10-19.
    3. Harman, D. Aging: a theory based on free radical and radiation chemistry. J. Gerontol., 1956, 11, p. 298-300. Go to original source... Go to PubMed...
    4. Waris, G., Ahsan, H. Reactive oxygen species: role in the development of cancer and various chronic conditions. Journal of Carcinogenesis, 2006, 5 (online), dostupný na www.carcinogenesis.com/content/5/1/14. Go to original source... Go to PubMed...
    5. Datta, K., Sinha, S., Chattopadhyay, P. Reactive oxygen species in health and disease. Natl. Med. J. India, 2000, 13, p. 304-310. Go to PubMed...
    6. Ricciardolo, F. L., Di Stefano, A., Sabatini, F., Folkerts, G. Reactive nitrogen species in the respiratory tract. Eur. J. Pharmacol., 2006, 8, p. 240-252. Go to original source... Go to PubMed...
    7. Comhair, S. A. A., Erzurum, S. C. Antioxidant responses to oxidant-mediated lung diseases. Am. J. Physiol. Lung Cell. Mol. Physiol., 2002, 283, L246-L255. Go to original source... Go to PubMed...
    8. Dröge, W. Free radicals in the physiological control of cell function. Physiol. Rev., 2002, 82, p. 47-95. Go to original source... Go to PubMed...
    9. Carmody, R. J., Cotter, T. G. Signalling apoptosis: a radical approach. Redox Rep., 2001, 6, p. 77-90. Go to original source... Go to PubMed...
    10. Bassi, G., Calzia, E., Hase, C., Simon, F., Nguyen, Duy, C., Radermacher, P., Matejovic, M. Hyperoxia during porcine faecal peritonitis: I. The lung, II. The hepato-splanchnic system. (abstrakta). V tisku, se svolením.
    11. Bitterman, H., Waisman, D., Brod, V., Weber, G., Lavon, O., Rahat, M., Lahat, N. Anti-inflammatory effects of hyperoxia in sepsis. In Proceedings of 32nd Annual Scientific Meeting of the E.U.B.S., 2006, Bergen, p. 62.
    12. Bitterman, H., Muth, C. M. Hyperbaric oxygen in systemic inflammatory response. Intensive Care Med., 2004, 28, p. 636-641. Go to original source... Go to PubMed...
    13. Imperatore, F., Cuzzocrea, S., Luongo, C., Liguori, G., Scafuro, A., De Angelis, A., Rossi, F., Caputi, A. P., Fillipelli, A. Hyperbaric oxygen therapy prevents vascular derangement during zymosan-induced multiple-organ-failure syndrom. Intensive Care Med., 2004, 30, p. 1175-1181. Go to original source... Go to PubMed...
    14. Öter, S., Radermacher, P., Matejovic, M. Can (hyperbaric) oxygen turn off the motor of multiorgan dysfunction? Editorial, Intensive Care Med., 2006, v tisku, se svolením. Go to original source...
    15. Lu, M. U., Kang, B. H., Wan, F. J., Chen, C. S., Huang, K. J. Hyperbaric oxygen attenuates lipopolysaccharide-induced acute lung injury. Intensive Care Med., 2002, 28, p. 636-641. Go to original source... Go to PubMed...
    16. Buras, J. A., Holt, D., Orlow, D., Belikoff, B., Pavlides, S., Reenstra, W. R. Hyperbaric oxygen protects from sepsis mortality via an IL-10-dependent mechanism. Crit. Care Med., 2006, 34, p. 2624-2629. Go to original source... Go to PubMed...
    17. Millar, I., Nikfarjam, M., Cuthbertson, C., Su, K., Malcontent-Wilson, C., Christophi, Ch. Hyperbaric oxygen therapy reduces severity and improves survival in acute severe pancreatitis. In Proccedings of Joint Meeting of the I.C.H.M. and E.U.B.S., 2005, Barcelona, p. 218.
    18. Demchenko, I. T., Bosso, A. E., O'Neill, T. J., Bennett, P. B. Nitric oxide and cerebral blood flow responses to hyperbaric oxygen. J. Appl. Physiol., 2000, 88, p. 1381-1389. Go to original source... Go to PubMed...
    19. Oury, T. D., Ho, Y. S., Piantadosi, C. A., Crapo, J. D. Extracellular superoxide dismutase, nitric oxide and central nervous system O2 toxicity. Proc. Natl. Acad. Sci. USA, 1992, 89, p. 9715-9719. Go to original source... Go to PubMed...
    20. Bitterman, N., Bitterman, H. L-Arginine-NO pathway and CNS oxygen toxicity. J. Appl. Physiol., 1998, 84, p. 1633-1638. Go to original source... Go to PubMed...
    21. Nellin, L. D., Welty, S. E., Morrisey, J. F., Gotyaco, C., Dawson, C. A. Nitric oxide increases the survival of rats with a high oxygen exposure. Pediatr. Res., 1998, 43, p. 727-732. Go to original source... Go to PubMed...
    22. Atochin, D., Demchenko, I., Huang, P., Piantadosi, P. Neuronal and endothelial nitric oxide are involved in hyperbaric pulmonary oxygen toxicity. In Proceedings of Joint Meeting of the I.C.H.M. and E.U.B.S., 2005, Barcelona, p. 99-100.
    23. Demchenko, I. T., Suliman, H. B., Tatro, L., Piantadosi, C. A. Protein S-nitrosylation of glutamate decarboxylase by HBO leads to GABA depletion and oxygen seizures. In Proceedings of 32nd Annual Scientific Meeting of E.U.B.S., 2006, Bergen, p.27.
    24. Muth, C., Gröger, M., Radermacher, P., Speit, G. Physiologic effects of hyperbaric oxygen on DNA repair-genotoxicity of hyperbaric oxygen and its prevention. In Mathieu, D. (ed.) Handbook on Hyperbaric Medicine, Dordrecht : Springer 2006, p. 147-159. Go to original source...
    25. Bitterman, N., Bitterman, H. Oxygen toxicity. In Mathieu, D.-(ed.) Handbook on Hyperbaric Medicine. Dordrecht : Springer, 2006, p. 731-765. Go to original source...
    26. Clark, J. M., Lambertsen, C. J. Rate of development of pulmonary oxygen toxicity in man during oxygen breathing at 2,0 ATA. J. Appl. Physiol., 1971, 30, p. 739-752. Go to original source... Go to PubMed...
    27. Clark, J. M., Lambertsen, C. J. Pulmonary oxygen toxicity: a review. Pharmacol. Rev., 1971, 23, p. 37-133. Go to PubMed...
    28. Clark, J. M., Lambertsen, C. J., Gelfand, R., Flores, N. D., Piserello, J. B., Rossman, D., Elias, J. A. Effects of prolonged oxygen exposure at 1.5, 2.0 or 2.5 ATA on pulmonary function in men. J. Appl. Physiol., 1999, 86, p. 243-259. Go to original source... Go to PubMed...
    29. Huber, G. L., Drath, D. B. Pulmonary oxygen toxicity. In Gilbert, D. L. (ed.) Oxygen and Living Processes. New York : Springer-Verlag 1981, p. 273-342. Go to original source...
    30. Thorsen, E., Aanderud, L., Aasen, T. B. Effects of standard hyperbaric oxygen treatment protocol on pulmonary function. Eur. Respiratory J., 1998, 12, p. 1442-1445. Go to original source... Go to PubMed...
    31. Tulachová, Z. Otrava kyslíkem v hyperbarické komoře. Sborník referátů VII. celostátního semináře o hyperbarické medicíně, 1984, Martin. s. 73-77, vydáno v Praze 1985.
    32. Clark, J. M., Thom, S. R. Toxicity of Oxygen and Carbon Monoxide. In Bove, A. A. (ed.) Bove and Davis' Diving Medicine. 4th Edition, Philadelphia : Saunders 2004, p. 241-259.
    33. Welslau, W., Almeling, M. Incidence of oxygen intoxication to the central nervous system in hyperbaric oxygen therapy. In Proc. of the Intl Joint Meeting on Hyperbaric and Underwater Medicine, 1996, Milan, p. 211-216.
    34. Hampton, N., Atik, D. Central nervous system oxygen toxicity during routine oxygen therapy. Undersea Hyperbaric Med., 2003, 30, p. 147-153.
    35. Yildiz, S., Ay, H., Qyrdedi, T. Central nervous system toxicity during routine hyperbaric oxygen therapy. Undersea Hyperbaric Med., 2004, 31, p. 189-190.
    36. Clark, J. M., Thom, S. R. Oxygen under pressure. In Brubbak, A. O., Neuman, T. S. (eds.) Physiology and Medicine of Diving, 5th Ed. Edinburgh : Sounders 2003, p. 358-418.
    37. Holbach, K. H., Caroli, A., Wassmann, Z. H. Cerebral energy metabolism in patients with brain lesions at normo and hyperbaric oxygen pressure. J. Neurol., 1977, 217, p. 17-30. Go to original source... Go to PubMed...
    38. Dennog, C., Gedik, C., Wood, S., Speit, G. Analysis of oxidative damage and HPRT mutations in humans after hyperbaric oxygen treatment. Mutat. Res., 1999, 431, p. 351-359. Go to original source... Go to PubMed...
    39. Speit, G., Dennog, C., Eichorn, U., Rothfuss, A., Kaina, B. Induction of heme oxygenase-1 and adaptive protection against the induction of DNA damage after hyperbaric oxygen treatment. Carcinogenesis, 2000, 21, p. 1795-1799. Go to original source... Go to PubMed...
    40. Arieli, Y., Kotler, D., Neuman, F., Arieli, R. Can hyperbaric preconditioning provide protection against CNS toxicity in the rat? In Proceedings of 32nd Annual Scientific Meeting of E.U.B.S., 2006, Bergen, p. 26.

    Return to the content


    Anesteziologie a intenzivní medicína

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.