Anest. intenziv. Med. 2006;17(2):102-109

Metabolism, endocrinology, and nutrition: Progress in 2005Intensive Care Medicine

M. Matějovič, A. Kroužecký, J. Raděj, R. Sýkora, I. Novák
JIP, I. interní klinika, Fakultní nemocnice a Lékařská fakulta UK, Plzeň

The purpose of this article is to review the literature in the year 2005 covering different aspects of metabolism, endocrinology and nutrition in critically ill patients. In particular, studies reviewed in this paper cover: glucose control and its consequences, putative mechanisms of protective effects affiliated with glucose control, new insights into the metabolism of lactate in the critically ill, low dose corticosteroids, the role of ethomidate in intensive care medicine, current concepts in nutrition, immunonutrition and antioxidant treatment.

Keywords: glucose control; lactate; metabolism; hormones; nutrition; critical illness; organ failure

Published: April 1, 2006  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Matějovič M, Kroužecký A, Raděj J, Sýkora R, Novák I. Metabolism, endocrinology, and nutrition: Progress in 2005. Anest. intenziv. Med. 2006;17(2):102-109.
Download citation

References

  1. Malmberg, K., Ryden, L., Efendic, S., Herlitz, J., Nicol, P., Waldenstrom, A., Wedel, H., Welin, L. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J. Am. Coll. Cardiol., 1995. 26, 1, p. 57-65. Go to original source... Go to PubMed...
  2. Malmberg, K., Ryden, L., Wedel, H., Birkeland, K., Bootsma, A., Dickstein, K., Efendic, S., Fisher, M., Hamsten, A., Herlitz, J., Hildebrandt, P., MacLeod, K., Laakso, M., Torp-Pedersen, C., Waldenstrom, A. DIGAMI 2 Investigators. Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity. Eur. Heart J., 2005, 26, 7, p. 650-661. Go to original source... Go to PubMed...
  3. Vanhorebeek, I., Langouche, L., Van den Berghe, G. Glycemic and nonglycemic effects of insulin: how do they contribute to a better outcome of critical illness? Curr. Opin. Crit. Care, 2005, 11, 4, p. 304-311. Go to original source...
  4. Jeremitsky, E., Omert, L. A., Dunham, C. M., Wilberger, J., Rodriguez, A. The impact of hyperglycemia on patients with severe brain injury. J. Trauma, 2005, 58, 1, p. 47-50. Go to original source... Go to PubMed...
  5. Laird, A. M., Miller, P. R., Kilgo, P. D., Meredith, J. W., Chang, M. C. Relationship of early hyperglycemia to mortality in trauma patients. J. Trauma, 2004, 56, 5, p. 1058-1062. Go to original source... Go to PubMed...
  6. Faustino, E. V., Apkon, M. Persistent hyperglycemia in critically ill children. J. Pediatr., 2005, 146, 1, p. 30-34. Go to original source... Go to PubMed...
  7. Matějovič, M., Novák, F., Kroužecký, A., Raděj, J., Novák, I. Metabolismus, endokrinologie a výživa - novinky 2004. Anest. intenziv. Med., 2005, 16, s. 57-64.
  8. Van den Berghe, G., Schoonheydt, K., Becx, P., Bruyninckx, F., Wouters, P. Insulin therapy protects the central and peripheral nervous system of intensive care patients. Neurology, 2005, 26, 64, 8, p. 1348-1353. Go to original source... Go to PubMed...
  9. Vanhorebeek, I., De Vos, R., Mesotten, D., Wouters, P. J., De Wolf-Peeters, C., Van den Berghe, G. Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet, 2005, 7, p. 53-59. Go to original source... Go to PubMed...
  10. Siroen, M. P., van Leeuwen, P. A., Nijveldt, R. J., Teerlink, T., Wouters, P. J., Van den Berghe, G. Modulation of asymmetric dimethylarginine in critically ill patients receiving intensive insulin treatment: a possible explanation of reduced morbidity and mortality? Crit. Care Med., 2005, 33, 3, p. 504-610. Go to original source... Go to PubMed...
  11. Langouche, L., Vanhorebeek, I., Vlasselaers, D., Vander Perre, S., Wouters, P. J., Skogstrand, K., Hansen, T. K., Van den Berghe, G. Intensive insulin therapy protects the endothelium of critically ill patients. J. Clin. Invest., 2005, 115, 8, p. 2277-2286. Go to original source... Go to PubMed...
  12. Hauser, B., Bracht, H., Matejovic, M., Radermacher, P., Venkatesh, B. Nitric oxide synthase inhibition in sepsis? Lessons learned from large-animal studies. Anesth. Analg., 2005, 101, 2, p. 488-498. Go to original source... Go to PubMed...
  13. Levy, B., Gibot, S., Franck, P., Cravoisy, A., Bollaert, P. E. Relation between muscle Na+K+ ATPase activity and raised lactate concentrations in septic shock: a prospective study. Lancet, 2005, 365, p. 871-875. Go to original source... Go to PubMed...
  14. Dellinger, R. P., Carlet, J. M., Masur, H., Gerlach, H., Calandra, T., Cohen, J. et al. Surviving Sepsis Campaign Guidelines for management of severe sepsis and septic shock. Intensive Care Med., 2004, 30, 4, p. 536-555. Go to original source... Go to PubMed...
  15. Revelly, J. P., Tappy, L., Martinez, A., Bollmann, M., Cayeux, M. C., Berger, M. M., Chiolero, R. L. Lactate and glucose metabolism in severe sepsis and cardiogenic shock. Crit. Care Med., 2005, 33, 10, p. 2235-2240. Go to original source... Go to PubMed...
  16. Keh, D., Sprung, C. L. Use of corticosteroid therapy in patients with sepsis and septic shock: an evidence-based review. Crit. Care Med., 2004, 32, 11, Suppl, S527-S33. Go to original source... Go to PubMed...
  17. Hollenberg, S. M., Ahrens, T. S., Annane, D., Astiz, M. E., Chalfin, D. B., Dasta, J. F. et al. Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update. Crit. Care Med., 2004, 32, 9, p. 1928-1948. Go to original source... Go to PubMed...
  18. Oppert, M., Schindler, R., Husung, C., Offermann, K., Graf, K. J., Boenisch, O., Barckow, D., Frei, U., Eckardt, K. U. Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdynamic septic shock. Crit. Care Med., 2005, 33, 11, p. 2457-2464. Go to original source... Go to PubMed...
  19. Venkatesh, B., Mortimer, R. H., Couchman, B., Hall, J. Evaluation of random plasma cortisol and the low dose corticotropin test as indicators of adrenal secretory capacity in critically ill patients: a prospective study. Anaesth. Intensive Care, 2005, 33, 2, p. 201-209. Go to original source... Go to PubMed...
  20. Siraux, V., De Backer, D., Yalavatti, G., Melot, C., Gervy, C., Mockel, J., Vincent, J. L. Relative adrenal insufficiency in patients with septic shock: Comparison of low-dose and conventional corticotropin tests. Crit. Care Med., 2005, 33, 11, p. 2479-2486. Go to original source... Go to PubMed...
  21. Hamrahian, A. H., Oseni, T. S., Arafah, B. M. Measurements of serum free cortisol in critically ill patients. N. Engl. J. Med., 2004, 15, 350, 16, p. 1629-1638. Go to original source... Go to PubMed...
  22. Annane, D., Bellissant, E., Bollaert, P. E., Briegel, J., Keh, D., Kupfer, Y. Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. BMJ, 2004, 28, 329, p. 480. Go to original source... Go to PubMed...
  23. Confalonieri, M., Urbino, R., Potena, A., Piattella, M., Parigi, P., Puccio, G., Della Porta, R., Giorgio, C., Blasi, F., Umberger, R., Meduri, G. U. Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study. Am. J. Respir. Crit. Care Med., 2005, 1, 171, 3, p. 242-248. Go to original source... Go to PubMed...
  24. Annane, D. ICU physicians should abandon the use of etomidate! Intensive Care Med., 2005, 31, 3, p. 325-326. Go to original source... Go to PubMed...
  25. Malerba, G., Romano-Girard, F., Cravoisy, A., Dousset, B., Nace, L., Levy, B., Bollaert, P. E. Risk factors of relative adrenocortical deficiency in intensive care patients needing mechanical ventilation. Intensive Care Med., 2005, 31, 3, p. 388-392. Go to original source... Go to PubMed...
  26. Annane, D., Sebille, V., Charpentier, C., Bollaert, P. E., Francois, B., Korach, J. M., Capellier, G., Cohen, Y., Azoulay, E., Troche, G., Chaumet-Riffaut, P., Bellissant, E. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA, 2002, 21, 288, 7, p. 862-871. Go to original source... Go to PubMed...
  27. Annane, D. Etomidate and intensive care physicians. Intensive Care Med., 2005, 31, 10, p. 1454. Go to original source...
  28. Murray, H., Marik, P. E. Etomidate for endotracheal intubation in sepsis: acknowledging the good while accepting the bad. Chest, 2005, 127, 3, p. 707-709. Go to original source... Go to PubMed...
  29. Heyland, D. K., Dhaliwal, R., Drover, J. W., Gramlich, L., Dodek, P. Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. J. Parenter. Enteral. Nutr., 2003, 27, p. 355-373. Go to original source... Go to PubMed...
  30. Gramlich, L., Kichian, K., Pinilla, J., Rodych, N. J., Dhaliwal, R., Heyland, D. K. Does enteral nutrition compared to parenteral nutrition result in better outcomes in critically ill adult patients? A systematic review of the literature. Nutrition, 2004, 20, 10, p. 843-848. Go to original source... Go to PubMed...
  31. Simpson, F., Doig, G. S. Parenteral vs. enteral nutrition in the critically ill patient: a meta-analysis of trials using the intention to treat principle. Intensive Care Med., 2005, 31, 1, p. 12-23. Go to original source... Go to PubMed...
  32. Peter, J. V., Moran, J. L., Phillips-Hughes, J. A metaanalysis of treatment outcomes of early enteral versus early parenteral nutrition in hospitalized patients. Crit. Care Med., 2005, 33, 1, p. 213-220. Go to original source... Go to PubMed...
  33. Malhotra, A., Mathur, A. K., Gupta, S. Early enteral nutrition after surgical treatment of gut perforations: a prospective randomised study. J. Postgrad. Med., 2004, 50, 2, p. 102-106.
  34. Kieft, H., Roos, A. N., van Drunen, J. D., Bindels, A. J., Bindels, J. G., Hofman, Z. Clinical outcome of immunonutrition in a heterogeneous intensive care population. Intensive Care Med., 2005, 31, 4, p. 524-532. Go to original source... Go to PubMed...
  35. Heyland, D., Dhaliwal, R. Immunonutrition in the critically ill: from old approaches to new paradigms. Intensive Care Med., 2005, 31, 4, p. 501-503. Go to original source... Go to PubMed...
  36. Tsuei, B. J., Bernard, A. C., Barksdale, A. R., Rockich, A. K., Meier, C. F., Kearney, P. A. Supplemental enteral arginine is metabolized to ornithine in injured patients. J. Surg. Res., 2005, 123, 1, p. 17-24. Go to original source... Go to PubMed...
  37. Zhou, Y. P., Jiang, Z. M., Sun, Y. H., Wang, X. R., Ma, E. L., Wilmore, D. The effect of supplemental enteral glutamine on plasma levels, gut function, and outcome in severe burns: a randomized, double-blind, controlled clinical trial. J. Parenter. Enteral. Nutr., 2003, 27, 4, p. 241-245. Go to original source... Go to PubMed...
  38. Fuentes-Orozco, C., Anaya-Prado, R., Gonzalez-Ojeda, A., Arenas-Marquez, H., Cabrera-Pivaral, C., Cervantes-Guevara, G., Barrera-Zepeda, L. M. L-alanyl-L-glutamine-supplemented parenteral nutrition improves infectious morbidity in secondary peritonitis. Clin. Nutr., 2004, 23, 1, p. 13-21. Go to original source... Go to PubMed...
  39. Xian-Li, H., Quing, M., Jiang, L. Effect of total parenteral nutrition (TPN) with and without glutamine dipeptide supplementation on outcome in severe acute pancreatitis (SAP). Clinical Nutrition Supplements, 2004, 1, p. 43. Go to original source...
  40. Schulman, A. S., Willcutts, K. F., Claridge, J. A., Evans, H. L., Radigan, A. E., O'Donnell, K. B., Camden, J. R., Chong, T. W., McElearney, S. T., Smith, R. L., Gazoni, L. M., Farinholt, H. M., Heuser, C. C., Lowson, S. M., Schirmer, B. D., Young, J. S., Sawyer, R. G. Does the addition of glutamine to enteral feeds affect patient mortality? Crit. Care Med., 2005, 33, 11, p. 2501-2506. Go to original source... Go to PubMed...
  41. Heyland, D. K., Dhaliwal, R., Suchner, U., Berger, M. M. Antioxidant nutrients: a systematic review of trace elements and vitamins in the critically ill patient. Intensive Care Med., 2005, 31, 3, p. 327-337. Go to original source... Go to PubMed...
  42. Halliwell, B. The antioxidant paradox. Lancet, 2001, 355, p. 1179-1180. Go to original source... Go to PubMed...
  43. Crimi, E., Liguori, A., Condorelli, M., Cioffi, M., Astuto, M., Bontempo, P. The beneficial effects of antioxidant supplementation in enteral feeding in critically ill patients: a prospective, randomized, double-blind, placebo-controlled trial. Nutr. Clin. Pract., 2005, 20, 3, p. 363-364. Go to original source...
  44. Jain, P. K., McNaught, C. E., Anderson, A. D., MacFie, J., Mitchell, C. J. Influence of symbiotic containing Lactobacillus acidophilus La5, Bifidobacterium lactis Bb 12, Streptococcus thermophilus, Lactobacillus bulgaricus and oligofructose on gut barrier function and sepsis in critically ill patients: a randomised controlled trial. Clin. Nutr., 2004, 23, 4, p. 467-475. Go to original source... Go to PubMed...
  45. McNaught, C. E., Woodcock, N. P., Anderson, A. D., MacFie, J. A prospective randomised trial of probiotics in critically ill patients. Clin. Nutr., 2005, 24, 2, p. 211-219. Go to original source... Go to PubMed...




Anesteziologie a intenzivní medicína

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.