Anest. intenziv. Med. 2006;17(2):85-94
Progress in the pathophysiology and therapy of ventilatory failure in critically ill patientsIntensive Care Medicine
- ARO Oblastní nemocnice Mladá Boleslav, a. s., Nemocnice Středočeského kraje
The article summarises progress in the understanding of the pathophysiology and therapy of ALI/ARDS including the main algorithms of mechanical ventilation from the perspective of evidence based medicine and pharmacological treatment, new modes of mechanical ventilation and recommendations for home ventilation.
Keywords: mechanical ventilation; ARDS; Evidence Based Medicine (EBM); pharmacotherapy; home ventilation
Published: April 1, 2006 Show citation
References
- Tremblay, L., Slutsky, A. Ventilator-induced lung injury: from barotrauma to biotrauma. Proc. Assoc. Am. Physicians, 1998, 110, p. 428-482.
- Gattinoni, L., Petenti, A. The concept of "baby lung". Int. Care Med., 2005, 31, p. 776-784.
Go to original source...
Go to PubMed...
- Marini, J., Gattinoni, L. Ventilatory management of acute respiratory distress syndrome: A consensus of two. Crit. Care Med., 2004, 32, p. 250-255.
Go to original source...
Go to PubMed...
- Kay, S., Bilek, A., Dee, K., Gaver, D. Pressure gradient, not exposure duration, determines the extent of epithelial cell damage in a model of pulmonary airway reopening. J. App. Phys., 2004, 97, p. 269-276.
Go to original source...
Go to PubMed...
- Vlahakis, N., Hubmayr, R. Cellular Stress Failure in Ventilator-injured Lungs. Am. J. Respir. Crit. Care Med., 2005, 171, p. 1328-1342.
Go to original source...
Go to PubMed...
- Hubmayr, R. Perspective on lung injury and recruitment: a skeptical look at the opening and collapse story. Am. J. Respir. Crit. Care Med., 2002, 165, s. 1647-1653.
Go to original source...
Go to PubMed...
- Bone, R. The ARDS Lung: New Insights From Computed Tomography. JAMA, 1993, 269, p. 2134-2135.
Go to original source...
Go to PubMed...
- Rouby, J. J., Qin, Lu, Goldstein, I. Selecting the Right Level of Positive End-Expiratory Pressure in Patients with Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med., 2002, 165, p. 1182-1186.
Go to original source...
Go to PubMed...
- Frank, J., Matthay, M. Leukotrienes in Acute Lung Injury: A Potential Therapeutic Target? Am. J. Respir. Crit. Care Med., 2005, 172, p. 261-262.
Go to original source...
Go to PubMed...
- Caironi, P., Ichinose, F., Lui, R., Jones, C., Bloch, K., Zapol, W. 5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury. Am. J. Respir. Crit. Care Med., 2005, 172, p. 334-343.
Go to original source...
Go to PubMed...
- Ye, S. Q., Simon, B. A., Maloney, J. P., Zambelli-Weiner, A., Gao, L., Grant, A., Easley, R. B., McVerry, B. J., Tuder, R. M., Standiford, T. Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury. Am. J. Respir. Crit. Care Med., 2005, 171, p. 361-370.
Go to original source...
Go to PubMed...
- Mingyao, Liu Searching for Acute Respiratory Distress Syndrome Genes: Aren't We There Yet? Am. J. Respir. Critical. Care Med., 2005, 171, p. 298-299.
Go to original source...
Go to PubMed...
- Marshall, R., Webb, S., Bellingan, G. T. al. Angiotensin Converting Enzyme Insertion/Deletion Polymorphism Is Associated with Susceptibility and Outcome in Acute Respiratory Distress Syndrome. Am. J. Resp. Crit. Care Med., 2002, 166, p. 646-650.
Go to original source...
Go to PubMed...
- dos Santos, C. C., Han, B., Andrade, C. F., Bai, X., Uhlig, S., Hubmayr, R., Tsang, M., Lodyga, M., Keshavjee, S., Slutsky, A. S. et al. DNA microarray analysis of gene expression in alveolar epithelial cells in response to TNFalpha, LPS, and cyclic stretch. Physiol. Genomics, 2004, 19, p. 331-342.
Go to original source...
Go to PubMed...
- Jeyaseelan, S., Chu, H. W., Young, S. K., Worthen, G. S. Transcriptional profiling of lipopolysaccharide-induced acute lung injury. Infect. Immun., 2004, 72, p. 7247-7256.
Go to original source...
Go to PubMed...
- Leikauf, G. D., McDowell, S. A., Wesselkamper, S. C., Hardie, W. D., Leikauf, J. E., Korfhagen, T. R., Prows, D. R. Acute lung injury: functional genomics and genetic susceptibility. Chest, 2002, 121, p. 70S-75S.
Go to original source...
Go to PubMed...
- Olman, M. A., White, K. E., Ware, L. B., Cross, M. T., Zhu, S., Matthay, M. A. Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1. Chest, 2002, 121, p. 69S-70S.
Go to original source...
Go to PubMed...
- Copland, I. B., Kavanagh, B. P., Engelberts, D., McKerlie, C., Belik, J., Post, M. Early changes in lung gene expression due to high tidal volume. Am. J. Respir. Crit. Care Med., 2003, 168, p. 1051-1059.
Go to original source...
Go to PubMed...
- Hopkins, R., Weaver, L., Collingridge, D. et al. Two-Year Cognitive, Emotional, and Quality-of-Life Outcomes in Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med., 2005, 171, p. 340-347.
Go to original source...
Go to PubMed...
- Flori, H., Glidden, D., Rutherford, G., Matthay, M. Pediatric Acute Lung Injury: Prospective Evaluation of Risk Factors Associated with Mortality. Am. J. Resp. Crit. Care Med., 2005, 171, p. 995-1001.
Go to original source...
Go to PubMed...
- Bernard, G. Acute Respiratory Distress Syndrome - A Historical Perspective. Am. J. Respir. Crit. Care Med., 2005, 172, p. 798-806.
Go to original source...
Go to PubMed...
- Burns, S. Mechanical ventilation of patients with ARDS and patients requiring weaning. Critical Care Nurse, 2005, 25, p. 14-23.
Go to original source...
- The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N. Engl. J. Med., 2000, 342, p. 1301-1307.
Go to original source...
Go to PubMed...
- Amato, M. B. P., Barbas, C. S. V., Medeiros, D. M., Magaldi, R. B., Schettino, G. P. P., Lorenzi-Filho, G., Kairalla, R. A., Deheinzelin, D., Muñoz, C., Oliveira, R., et al. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N. Engl. J. Med., 1998, 338, p. 347-354.
Go to original source...
Go to PubMed...
- Sakr, Y., Vincent, J. L., Reinhart, K., Groeneveld, J. et al. High Tidal Volume and Positive Fluid Balance Are Associated With Worse Outcome in Acute Lung Injury. Chest, 2005, 128, p. 3098-3108.
Go to original source...
Go to PubMed...
- Trembley, L., Slutsky, A. Ventilator-induced lung injury: from the bench to the bedside. Intens. Care Med., 2006, 32, p. 24-33.
Go to original source...
- Esteban, A., Anzueto, A., Alia, I. et al. How is mechanical ventilation employed in the intensive care unit? Am. J. Respir. Crit. Care Med., 2000, 161, p. 1450-1458.
Go to original source...
Go to PubMed...
- Brower, R. Higher versus Lower Positive End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome. N. Eng. J. Med., 2004, 351, p. 327-336.
Go to original source...
Go to PubMed...
- http://www.vrr.ulaval.ca/bd/projet/fiche/75905.html
- Grasso, S. et al. Effects of High versus Low Positive End-Expiratory Pressures in Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med., 2005, 171, p. 1002-1008.
Go to original source...
Go to PubMed...
- Derdak, S., Mehta, S., Stewart, T. E. et al. High frequency oscillatory ventilation for acute respiratory distress syndrome in adults: A randomized, controlled trial. Am. J. Respir. Crit. Care Med., 2002, 66, p. 801-808.
Go to original source...
Go to PubMed...
- Mehta, S., Granton, J., MacDonald, R. J. et al. High-frequency oscillatory ventilation in adults: The Toronto experience. Chest, 2004, 126, p. 518-527.
Go to original source...
Go to PubMed...
- Ferguson N. et al. Combining high-frequency oscillatory ventilation and recruitment maneuvers in adults with early acute respiratory mistress syndrome: The Treatment with Oscillation and an Open Lung. Strategy (TOOLS). Trial pilot study. Crit. Care Med., 2005, 33, p. 479-486.
Go to original source...
Go to PubMed...
- Meduri, G. U. et al. Effect of Prolonged Methylprednisolone Therapy in Unresolving Acute Respiratory Distress Syndrome: A Randomized Controlled Trial. JAMA, 1998, 280, p. 159-165.
Go to original source...
Go to PubMed...
- Hudson, L. Report of the NHLBI Trial of Corticosteriods in Late ARDS. Annual Meeting of the American Thoracic Society Meeting, Orlando, Fl 2004.
- Herridge, M. S, et al. The Canadian Critical Care Clinical Trials Group. One year outcomes of the survivors of the acute respiratory distress syndrome. N. Engl. J. Med., 2003, 348, p. 683-693.
Go to original source...
Go to PubMed...
- Seeger, W., Spragg, R. G., Taut, F. J. H., Hafner, D., Lewis, J. F. Treatment with rSP-C surfactant reduces mortality in ARDS due to primary pulmonary events. Am. Thor. Society, 2002.
- Spragg, R. et al. Treatment of Acute Respiratory Distress Syndrome with Recombinant Surfactant Protein C Surfactant. Am. J. Respir. Crit. Care Med., 2003, 167, p. 1562-1566.
Go to original source...
Go to PubMed...
- Onarheim, H., Vik, V. Curosurf for acute respiratory failure after near-drowning in 12 year old. Acta Anaesthes. Scan., 2004, 48, p. 778.
Go to original source...
Go to PubMed...
- Walmrath, D. et al. Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on gas exchange and haemodynamics. Eur. Respir. J., 2002, 19, p. 805-810.
Go to original source...
Go to PubMed...
- Laterre, P. F., Wittebole, X., Dhainaut, J. F. Anticoagulant therapy in acute lung injury. Crit. Care Med., 2003, 31, p. S329-S336.
Go to original source...
Go to PubMed...
- Bernard, G. R. et al. Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N. Engl. J. Med., 2001, 344, p. 699-709.
Go to original source...
Go to PubMed...
- Hermann, P. et al. Inhaled nitric oxide therapy in adults: European expert recommendations. Int. Care Med., 2005, 31, p. 1029-1041.
Go to original source...
Go to PubMed...
- Gerlach, H. et al. Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe ARDS. A Prospective, Randomized, Controlled Study. Am. J. Resp. Crit. Care Med., 2003, 167, p. 1008-1015.
Go to original source...
Go to PubMed...
- Chen, F., Lam, J. et al. Two Aerosolized Nitric Oxide Adducts as Selective Pulmonary Vasodilators for Acute Pulmonary Hypertension. Chest, 2003, 123, p. 869-874.
Go to original source...
Go to PubMed...
- Hong, Pyo Kim, Ryter, S. W., Augustine, M. K. CO as a cellular signaling molecule. Ann. Rev. Pharm. Toxicol., 2006, 46, p. 411-449.
Go to original source...
Go to PubMed...
- Coburn, R. F. The carbon monoxide body stores. Ann. N. Y. Acad. Sci., 1970, 174, p. 11-22.
Go to original source...
Go to PubMed...
- Dolinay, T., Szilasi, M., Liu, M., Choi, M. K. A. Inhaled Carbon Monoxide Confers Antiinflammatory: Effects against Ventilator-induced Lung Injury. Am. J. Respir. Crit. Care Med., 2004, 170. p. 613-620.
Go to original source...
Go to PubMed...
- Mayr, F. et al. Effects of Carbon Monoxide Inhalation during Experimental Endotoxemia in Humans. Am. J. Resp. Crit. Care Med., 2005, 171, p. 354-360.
Go to original source...
Go to PubMed...
- Rossignol, D. et al. Safety, Pharmacokinetics, Pharmacodynamics, and Plasma Lipoprotein Distribution of Eritoran (E5564) during Continuous Intravenous Infusion into Healthy Volunteers. Antimicrobial Agents and Chemotherapy, 2004, 48, p. 3233-3240.
Go to original source...
Go to PubMed...
- Zhou, Z., Kozlowski, J., Schuster, D. Physiologic, Biochemical, and Imaging Characterization of Acute Lung Injury in Mice. Am. J. Resp. Crit. Care Med., 2005, 172, p. 344-351.
Go to original source...
Go to PubMed...
- Laffey, J. G., Kavanagh, B. P. Carbon dioxide and the critically ill: too little of a good thing? Lancet, 1999, 354, p. 1283-1286.
Go to original source...
Go to PubMed...
- Laffey, J. G., Honan, D., Hopkins, N., Hyvelin, J. M., Boylan, J. F., McLoughlin, P. Hypercapnic acidosis attenuates endotoxin-induced acute lung injury. Am. J. Respir. Crit. Care Med., 2004, 169, p. 46-56.
Go to original source...
Go to PubMed...
- Laffey, J. G., Jankov, R. P., Engelberts, D., Tanswell, A. K., Post, M., Lindsay, T., Mullen, J. B., Romaschin, A., Stephens, D., McKerlie, C. et al. Effects of therapeutic hypercapnia on mesenteric ischemia-reperfusion injury. Am. J. Respir. Crit. Care Med., 2003, 168, p. 1383-1390.
Go to original source...
Go to PubMed...
- Broccard, A. F., Hotchkiss, J. R., Vannay, C., Markert, M., Sauty, A., Feihl, F., Schaller, M. D. Protective effects of hypercapnic acidosis on ventilator-induced lung injury. Am. J. Respir. Crit. Care Med., 2001, 164, p. 802-806.
Go to original source...
Go to PubMed...
- Lang, J. D., Figueroa, M., Sanders, K. D., Aslan, M., Liu, Y., Chumley, P., Freeman, B. A. Hypercapnia via reduced rate and tidal volume contributes to lipopolysaccharide-induced lung injury. Am. J. Respir. Crit. Care Med., 2005, 171, p. 147-157.
Go to original source...
Go to PubMed...
- Lang, J. D. Jr, Chumley, P., Eiserich, J. P., Estevez, A., Bamberg, T., Adhami, A., Crow, J., Freeman, B. A. Hypercapnia induces injury to alveolar epithelial cells via a nitric oxide-dependent pathway. Am. J. Physiol. Lung Cell Mol. Physiol., 2000, 279, p. L994-L1002.
Go to original source...
Go to PubMed...
- Doerr, C., Gajic, O., Berrios, J., Caples, S., Abdel, M., Lymp, J., Hubmayr, R. Hypercapnic Acidosis Impairs Plasma Membrane Wound Resealing in Ventilator-injured Lungs. Am. J. Respir. Crit. Care Med., 2005, 171, p. 1371-1377.
Go to original source...
Go to PubMed...
- Kavanagh, B. Therapeutic Hypercapnia. Careful Science, Better Trials. Am. J. Resp. Crit. Care Med., 2005, 171, p. 96-97.
Go to original source...
Go to PubMed...
- Laffey, J. G., Kavanagh, B. P. Hypocapnia (Review). N. Engl. J. Med., 2002, 347, p. 43-53.
Go to original source...
Go to PubMed...
- Myrianthefs, P. et al. Hypocapnic but Not Metabolic Alkalosis Impairs Alveolar Fluid Reabsorption. Am. J. Resp. Crit. Care Med., 2005, 171, p. 1267-1271.
Go to original source...
Go to PubMed...
- Reignier, J. et al. Short-term effects of prone position in chronic obstructive pulmonary disease patients with severe acute and hypercapnic respiratory failure. Intensive Care Med., 2005, 31, p. 1128-1131.
Go to original source...
Go to PubMed...
- Gattinoni, L. et al. Effect of Prone Positioning on the Survival of Patients with Acute Respiratory Failure. N. Eng. J. Med., 2001, 345, p. 568-573.
Go to original source...
Go to PubMed...
- Gattinoni, L. et al. Decrease in PaCO2 with Prone Position is Predictive of Improved Outcome in ARDS. Crit. Care Med., 2003, 31, p. 2727-2733.
Go to original source...
Go to PubMed...
- Messerole, E., Marini, J., Albert, R. The pragmatics of prone positioning. Am. J. Resp. Crit. Care Med., 2002, 165, p. 1359.
Go to original source...
Go to PubMed...
- L'Her, E., Deye, A., Lellouche, F., Taille, S., Demoule, A., Fraticelli, A., Mancebo, J., Brochard, L. Physiologic Effects of Noninvasive Ventilation during Acute Lung Injury. Am. J. Resp. Crit. Care Med., 2005, 172, p. 1112-1118.
Go to original source...
Go to PubMed...
- Gay, P. C., Hess, D. R., Hill, N. S. Non-invasive proportional assist ventilation for acute respiratory insufficiency. Am. J. Respir. Crit. Care Med., 2001, 164, p. 1606-1611.
Go to original source...
Go to PubMed...
- Wysocki, M., Richard, J. C., Meshaka, P. Non-invasive proportional assist ventilation compared with non-invasive pressure support ventilation in hypercapnic acute respiratory failure. Crit. Care Med., 2002, 30, p. 323-329.
Go to original source...
Go to PubMed...
- Spahija, J., Beck, J., de Marchie, M., Comtois, A., Sinderby, C. Closed-Loop Control of Respiratory Drive Using Pressure-Support Ventilation: Target Drive Ventilation. Am. J. Resp. Crit. Care Med., 2005, 171, p. 1009-1014.
Go to original source...
Go to PubMed...
- Arold, S. P., Mora, R., Lutchen, K. R. et al. Variable tidal volume ventilation improves lung mechanics and gas exchange in a rodent model of acute lung injury. Am. J. Respir. Crit. Care Med., 2002, 165, p. 366-371.
Go to original source...
Go to PubMed...
- Jubran, A., Grant, B., Laghi, F., Parthasarathy, S., Tobin, M. Weaning Prediction: Esophageal Pressure Monitoring Complements Readiness Testing. Am. J. Resp. Crit. Care Med., 2005, 171, p. 1252-1259.
Go to original source...
Go to PubMed...
- American Thoracic Society: Statement on Home Care for Patients with Respiratory Disorders. Am. J. Resp. Critical. Care Med., 2005, 171, p. 1443-1464.
Go to original source...
Go to PubMed...