Anest. intenziv. Med. 1999;10(3):111-116

Oral clonidine in premedication for laparoscopic cholecystectomy - a comparison of different protocolsArticles

J. Málek, L. Hess¹, J. Knor, A. Kurzová

Klinika anesteziologie a resuscitace 3. LF UK Praha, přednosta doc. MUDr. Jan Pachl, CSc.

¹ IKEM Praha, ředitel MUDr. Karel Filip, CSc.

Oral clonidine in premedication for laparoscopic cholecystectomy - a comparison of different protocols42 patients scheduled for laparoscopic cholecystectomy were premedicated with clonidine 0,25 mg orally in the morning of the surgery. We did notobserve the presumed attenuation of hemodynamic response to capnoperitoneum after clonidine premedication. In comparison between clonidine 0,25mg orally, 0,15 mg intramuscularly and 2 mcg/kg intravenously or 4 mcg/kg intravenously, all parenteral forms of application resulted in similarresponses. We did not observe any difference in fentanyl consumption or the incidence of side effects. The authors recommend routine premedicationwith clonidine 2 mcg/kg intravenously in 100 mls of normal saline prior to laparoscopic cholecystectomy.

Keywords: clonidine; laparoscopic cholecystectomy; adverse hemodynamic changes

Published: June 1, 1999  Show citation