Anest. intenziv. Med. 2005;16(2):87-92

A Single-shot Caudal Block with Clonidin for Hypospadia Repair in ChildrenAnaesthesiology - Original Paper

I. Otáhal1, K. Pelikán1, T. Výška2, P. Ševčík1
1 Anesteziologicko-resuscitační klinika, FN u sv. Anny v Brně
2 Klinika plastické a estetické chirurgie, FN u sv. Anny v Brně

Objective:
Our aim was to introduce single-shot caudal epidural block with bupivacaine and clonidin as a standard analgesic component of general anaesthesia in children undergoing hypospadia repair. We focused on analgesia after surgery and its side-effects.

Design:
Open prospective observation.


Setting:
Department of Anaesthesia and Intensive Care and Department of Plastic and Aestetic Surgery, St. Ann's University Hospital Brno, Czech Republic.


Material and Method:
66 boys were included into the study. Bupivacaine (2 mg/kg) and clonidin (2.5 mcg/kg) with saline were injected into the caudal space in the volume of 0.5 ml/kg. The block was performed under general anaesthesia.

Results:
The mean age of patients was 54.86 ± 9.11 months, mean body weight 18.81 ± 9.11 kg. Spontaneous ventilation was sufficient, circulation was stable. The children were discharged from the operating theatre 2.6 minutes after the end of the surgery (range 0.5-7 minutes). 53 boys didn't require any analgesia at the day of surgery, remaining 13 boys received the first dose of analgesics 10.3 hours (3.5-16 hours) after the caudal block.

Conclusion:
A single-shot caudal administration of the mixture containing bupivacaine 2 μg/kg and clonidin 2.5 ug/kg (total volume 0.5 ml/kg) provides reliable perioperative analgesia in the patients. The final assessment of epidural clonidin requires further research.

Keywords: postoperative analgesia; caudal block; clonidin; children; anaesthesia; pain

Published: April 1, 2005  Show citation

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Otáhal I, Pelikán K, Výška T, Ševčík P. A Single-shot Caudal Block with Clonidin for Hypospadia Repair in Children. Anest. intenziv. Med. 2005;16(2):87-92.
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References

  1. Mathew, P. J., Mathew, J. L. Assessment and management of pain in infants. Postgrad. Med. J., 2003, 79, p. 438-443. Go to original source... Go to PubMed...
  2. Bjorkman, R., Hallman, K. M., Hedner, J., Hedner, T., Henning, M. Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P. Pain, 1994, 57, p. 259-264. Go to original source... Go to PubMed...
  3. Sittl, R., Griesinger, N., Koppert, W., Likar, R. Postoperative Schmerztherapie bei Kindern und Jugendlichen. Schmerz, 2000, 14, s. 333-339. Go to original source... Go to PubMed...
  4. Rose, J. B., Finkel, J. C., Arquedas-Mohs, A., Himelstein, B. P., Schneider, M., Medve, R. A. Oral Tramadol for the Treatment of Pain of 7-30 Days'Duration in Children. Anaesth. Analg., 2003, 96, p. 78-81. Go to original source...
  5. Joshi, W., Connelly, N. R., Reuben, S. S., Wolckenhaar, M., Thakkar, N. An Evaluation of the Safety and Efficacy of Administering Rofecoxib for Postoperative Pain Management. Anaesth. Analg., 2003, 97, p. 35-38. Go to original source... Go to PubMed...
  6. Beasley, S. W., Tibballs, J. Efficacy and safety of continuous morphine infusion for postoperative analgesia in the paediatric surgical ward. Aust. N. Z. J. Surg., 1987, 57, p. 233-237. Go to original source... Go to PubMed...
  7. Eck, J. B., Ross, A. K. Paediatric regional anaesthesia - what makes a difference? Best Practice and Research Clinical Anaesthesiology, 2002, 2, p. 159-174. Go to original source... Go to PubMed...
  8. Marhofer, P., Koinig, H., Kapral, S. Kaudalanasthesie - Die Wahl der Medikamente fur die Kaudalanasthesie bei Kindern. Anaesthesist, 2003, 52, s. 55-67. Go to original source... Go to PubMed...
  9. De Beer, D. A. H., Thomas, M. L. Caudal aditives in children - solutions or problems? Br. J. Anaesth., 2003, 90, p. 487-498. Go to original source... Go to PubMed...
  10. Mixa, V. Levobupivakain - dávkování v anestezii dětí. Anest. intenz. Med., 2003, 14, s. 259-261.
  11. Mix a, V., Cv acho vec, K., Rous ko vá, B., Zít kov á, M. Kontinuální kaudální blok u dětí. Anest. neodkl. Péče, 2002, 13, s. XVII-XX.
  12. Paalzou, L. Analgesia produced by clonidine in mice and rats. J. Pharm. Pharmacol., 1974, 26, p. 361-362. Go to original source... Go to PubMed...
  13. Cook, B., Grubb, D.J., Aldridge, L. A. et al. Comparison of the effects of adrenaline, clonidine and ketamine on the duration of the caudal analgesia produced by bupivacaine in children. Br.J. Anaesth., 1995, 75, p. 698-701. Go to original source... Go to PubMed...
  14. De Negri, P., Ivani, G., Visconti, C. et al. The dose-response relationship of clonidine added to a postoperative continuous epidural infusion of ropivacaine in children. Anaest. Analg., 2001, 93, p. 71-76. Go to original source... Go to PubMed...
  15. Lee, J. J., Rubin, A. P. Comparison of a bupivacaine-clonidine mixture with plain bupivacaine for caudal analgesia in children. Br. J. Anaesth., 1994, 72, p. 258-262. Go to original source... Go to PubMed...
  16. Jamali, S., Monin, S., Begon, C., Dubousset, A., Eccoffey, C. Clonidine in pediatric caudal anesthesia. Anesth. Analg., 1994, 78, p. 663-666. Go to original source... Go to PubMed...
  17. Luz, G., Innerhofer, P., Oswald, E., Salner, E., Hager, J., Sparr, H. Comparison of clonidine 1 μg/kg with morphine 30 ug/kg for post-operative caudal analgesia in children. Eur. J. Anaesthesiol., 1999, 16, p. 42-46. Go to original source...
  18. De Negri, P., Ivani, G., Visconti, C. et al. How to prolong postoperative analgesia after caudal anaesthesia with ropivacaine in children: S-ketamine versus clonidine. Paediatr. Anaesth., 2001, 11, p. 679-683. Go to original source... Go to PubMed...
  19. Motsch, J., Bottiger, B. W., Bach, A. et al. Caudal clonidine and bupivacaine for combined epidural and general anaesthesia in children. Acta Anaesthesiol. Scand., 1997, 41, p. 877-883. Go to original source... Go to PubMed...
  20. Hansen, T. G., Henneberg, S. W., Walther-Larsen, S., Lund, J., Hansen, M. Caudal bupivacaine supplemented with caudal or intravenous clonidine in children undergoing hypospadias repair: a double-blind study. Br. J. Anaesth., 2004, 92, p. 223-227. Go to original source... Go to PubMed...
  21. Ivani, G., Conio, A., De Negri, P., Eksborg, S., Lonnqvist, P. A. Spinal versus peripheral effects of adjunct clonidine: comparison of the analgesic effect of a ropivacaine-clonidine mixture when administered as a caudal or ilioinguinal-iliohypogastric nerve blockade for inguinal surgery in children. Paediatr. Anaesth., 2002, 12, p. 680-684. Go to original source... Go to PubMed...
  22. McGrath, P. J., Johnson, G., Goodman, J. T., Schillinger, J., Dunn, J., Chapman, J. CHEOPS: A Behavioral Scale for Rating Postoperative Pain in Children. Advances in Pain Research and Therapy, 1985, 9, p. 395-402.
  23. Giaufre, E., Dalens, B., Gombert, A. Epidemiology and Morbudity of Regional Anesthesia in Children: A One-Year Prospective Survey of the French-Language Society of Pediatric Anesthesiologists. Anesth. Analg., 1996, 83, p. 904-912. Go to original source...
  24. Foster, R. L., Yucha, C. B., Zuk, J., Vojir, C. P. Physiologic Correlates of Comfort in Healthy Children. Pain Management Nursing, 2003, 1, p. 23-30. Go to original source... Go to PubMed...
  25. Ivani, G., De Negri, P., Conio, A., Amat i, M. et al. Ropivacaine-clonidine combination for caudal blockade in children. Acta Anaesthesiol. Scand., 2000, 44, p. 446-449. Go to original source... Go to PubMed...




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