881
ABSTRAKTY3363200011158114164221282345406464520
Z3909200011151
KONGRESU3986200011156116178239299356406466
/4478200011132
CONGRESS4536200011154116177239299355406456
ABSTRACTS5018200011158114164221282345401459509
(LIVES)2480320097236080125166206229
Physiology27263200974287124156175220240284330369
is31123200971951
the31803200972671112
only33093200974489109147
polar34733200974691111150177
star3667320097315999126
we38103200975899
have39263200974483121161
–410432009740
unikátní41613200974489108146186213258277
akce44553200973977112152
proběhla46243200974673117163205250269308
již4949320097203974
potřetí50403200974591118144185212231
v528832009739
Praze53443200974268108143184
|5584190011126
125565419001113683130
/23748040010732
Anest24518040010752100145178207
intenziv267880400107196794136184221240282
Med.29798040010770115165181
2026;37(2):116-1253179804001074487129171186230271291334356370407442481511549587631
/38558040010731
ANESTEZIOLOGIE39528040010753112155200245290342362424467527586607650
A46248040010752
INTENZIVNÍ4698804001071978123168226276296345405426
MEDICÍNA51458040010770114174195248268327381
www.aimjournal.cz4258040010765133201214257275349367415463490539579598614654693
Background:56562001054586126164211237284331379428443
Microplastics103462001056887127154200250269309342371390430464
and152462001054088137
nanoplastics168762001054787135183232252292325354372412447
(MNPs)216062001052390147192224245
are243162001054167109
pervasive256662001054994120163204237256296339
environmental42576001054390128147173219266338381428454495513
contaminants95476001053985132159199271289336375422448482
with145376001056382109156
potential162576001054997124165212238257296314
human195676001054793165205251
health222476001054790129147175222
implications.246276001051890138157175215255282300347394427443
Although4259000105517098145192240288335
laboratory77990001051858107155181222249294321363
models1160900010573120169212231263
implicate144290001051890139158176215256283324
MNPs1785900010568125169201
in200590001051865
oxidative208990001054784103151191217236276318
stress,24269000105336188130163195211
inflammation,265690001051865881101502224251040010572112139157204252267
and712104001054087136
endocrine868104001054290138185226252270317361
disruption,124910400105486698124171220247265312360375
a16441040010540
comprehensive1704104001053985158206233275322365412445463503545
synthesis2269104001053373122148195238272289321
of2611104001054670
direct270110400105486692134175204
in425118001051865
vivo51511800105405999146
human685118001054794166206253
evidence963118001054282101149193240280321
is1309118001051850
lacking.138411800105195898135155202250266
We16751180010572113
aimed1813118001054058130173222
to2060118001052773
systematically2158118001053273106134176248288315333373413432450489
review2672118001052668108127170234
studies425132001053361108157175218251
measuring6931320010572115155187233259278325373
MNPs10831320010569125169201
in1301132001051966
living13841320010518367696142191
human1592132001054793165205252
subjects1861132001053379128146189230259294
and2172132001053987135
summarise2324132001053379151223263289307340383
associated272413200105407210515242514600105395897124165214
health664146001054891130149176223
findings.91314600105234289137156203251283299
Methods:12381460010568111139186233282315330
We15931460010572113
systematically1731146001053373106135176248288315334373414432451490
searched2246146001053376115141179226270319
PubMed,2590146001054490139208251300315
Web4251600010572113162
of608160001054770
Science,70016000105418199142189229270284
Scopus,1006160001054181126175223255271
Cochrane1298160001055096136183209250297340
and1660160001054087135
Embase18171600010541112161202234277
through2116160001052774100146193242289
262426160001054385
December25321600010557101141183255303347373
2024.425174001054385126165180
Two629174001054099145
investigators798174001051965104146179208226275314341387413447
independently1268174001051966114157206250297345389436462481520
screened181217400105337298140184231275324
and2159174001054088136
selected231917400105327695138178208249299
original264117400105477392140159206246264
research425188001052668101144184210248295
articles73918800105406696115154173216249
that1007188001052774114141
quantified1167188001054794134181207226249269312361
MNPs15471880010568124169201
in1767188001051865
biological1851188001054968115134181230249288329347
samples2217188001053374146195214257290
from252618800105235096169
living27141880010518377796143191
humans.425202001054896170211259292309
We7612020010574116
excluded904202001054383123142190239284334
animal,1265202001054189108181223242257
in1549202001051967
vitro,164320200105406089116163178
cell-line,1848202001054083102121149170189237281296
and2171202001054189139
injection-based233720200105186786130171202221269318347398440473518568
studies,425216001053361108156174217250265
as706216001054073
well7952160010563106124143
as954216001054072
reports1042216001052668116164191221255
on1313216001054794
non-plastic1423216001054794142169219238277310338356396
micro-1835216001057290129155201229
and2081216001053986134
nanoparticles.2232216001054786133180229270296326344383402445478494
Data2742216001055796123163
extraction,425230001054382112138179218248267314361376
performed826230001054892118145191218290334383
in1233230001051865
duplicate,1322230001054895143163181220261287329343
included1689230001051966106124170219262311
study2024230001053361108157196
design,2245230001054791124141190237252
participant2521230001054989115146164204222270311358385
characteristics,425244001053986126152192232261303329348380408426466500515
detection956244001054891118160200230248295343
methods,13152440010572115142189236285318333
polymer1664244001054997116155228271297
types,1977244001052769118162195211
and2204244001054087135
reported2355244001052668116164191221262311
health2682244001054891130148176223
outcomes.425258001054794122160205278321354371
Methodological8192580010569112139187234283331350397446464504544563
quality1406258001054894134153171198240
was16702580010563104137
appraised1830258001054089138164205223255299348
using220225800105467996143192
Risk241725800105456496133
Of2573258001055985
Bias2681258001054563103135
in2840258001051865
Non-Randomized4252720010556104151179225265312361408481499535577626
Studies1073272001054167114162181223256
–13522720010544
of1418272001054771
Exposures1511272001054181130178211257283325358
(ROBINS-E).1892272001052367127172190247286314357381394
The2308272001054190133
primary246327200105497594166206232274
outcome2759272001054794122425286001053984156198
was6392860010563103135
the790286001052774116
presence922286001054874116148191238277318
and1255286001054086134
burden1405286001054895120167209256
of1677286001054669
MNPs;17622860010568123167199213
secondary1991286001053275115160207255294319361
outcomes2368286001054693120157202274317349
were27332860010563105130172
clinical42530000105395876123141180221240
or684300001054774
biomarker777300001054968115187227253291333359
associations.1156300001054072105152193211250277296343390423439
No16153000010556103
metaanalysis17383000010572115143183223270310329368401419451
was22093000010563104136
performed2365300001054993119145192218291334383
due2768300001054894137
to425314001052773
heterogeneity.517314001054791118160186232281324371414433460502514
Results:1050314001054488121167185213247262
From1331314001054165111183
515343140010543
5221596314001054384127
records,1742314001052668108154180228260276
252037314001054386
studies2142314001053362109157175218251
met24123140010573116143
inclusion.2575314001051865105123169202220267314330
Studies425328001054167114163182225258
employed7093280010543115164184231270313362
pyrolysis–gas1097328001054988115161181220254272304348399439472
chromatography/mass1595328001053987113159232273299345395421462511559597626696736769802
spectrometry2423328001053381126166196223269342386413440482
(n425342001052469
=5063420010552
9),57034200105436679
Raman675342001054586159200248
spectroscopy949342001053382126167198224271304345391441480
(n1455342001052469
=15363420010553
8),160034200105436680
infrared170634200105186689117158185227277
spectroscopy2009342001053382127168198225272305345392441480
(n2516342001052369
=25963420010553
7),266134200105436781
and2768342001054088137
Fourier-transform425356001054188136162181225251275303330371419452477524551624
infrared107535600105196690117159185228277
spectroscopy1378356001053382127168198225271304345391441480
(n1884356001052469
=19643560010553
3),202935600105436478
often2133356001054771102145192
combined2352356001053985159208227275318368
with2746356001056484111159
microscopy425370001057291130156202235275321370409
for85937000105237097
MNP9813700010569125170
detection.1176370001054892119161201231249297344360
Predominant1562370001054470112161208281299346386433460
polymers2047370001054997117156229273299332
were24053700010564106132174
polyethylene,2605370001054997116156198226273425384001053959103151194209
polypropylene,660384001054998118158208235282331371391434482526541
polyvinyl1227384001054998117157201221268307327
chloride,1580384001053987106154181200249293308
polyethylene1914384001054998117157200228276314334378426470
terephthalate,241038400105277096139188237263311352371411438481495
and425398001054087136
polystyrene.586398001054997116155189217259286328375419433
In1045398001051865
cardiovascular1136398001053980106153171219258299331371418437476502
research1664398001052668101144184210248295
(51985398001052364
studies;2075398001053361108157175218251266
n23663980010547
=24253980010552
454),2488398001054384127148162
higher2675398001054866114161204230
thrombus42541200105277499145216264311343
and784412001053986133
plasma933412001054867107139210249
MNP11984120010568123167
burdens1381412001054895120167209256288
correlated1684412001053984110137178197236262303352
with2051412001056382109156
inflammatory222241200105196588109148220291330356402428469
markers27074120010571111136173425426001054369102
and553426001054087135
adverse714426001054088129171197231274
cardiac1014426001053980105153171211250
events.1290426001054383125172198233249
Reproductive1565426001054487136163209258304344374392433475
research2066426001052568101144183209248295
(seven238642600105245598138181228
studies;2639426001053362109157175218251266
n4254400010547
=4834400010553
327)547440001054383123147
linked72044000105193784121163212
semen958440001053376148191239
and1222440001054087136
tissue138344000105274678111157200
MNPs16094400010568125169201
to1836440001052773
reduced1934440001052668117164204245294
sperm2254440001053381125151224
quality2503440001054895135153171199241
and2769440001054087136
accumulation425454001053978114160230275293331357375420466
in906454001051864
tumor985454001052672142188214
and1214454001053985131
placental1360454001054867105143184230255294312
samples.1687454001053272142189207249281296
Gastrointestinal1998454001055493125152178222240286311351383410428474512530
research254345400105256698140178203240286
(92843454001052362
studies;425468001053361108156174217249264
n7054680010547
=7634680010552
537)826468001054283122146
associated988468001054072105152192210250276317366
fecal1370468001052366106146165
MNPs15514680010568124168200
with1767468001056382109156
liver194046800105183676118144
enzyme2100468001054390125167240283
elevations2399468001054362104144185211229276323356
and2771468001054086134
gut425482001054894122
dysbiosis.566482001054887120168187234267285317334
Respiratory918482001054588121169188214255281327353395
(31332482001052365
studies;1415482001053362109157175218251266
n16994820010548
=17584820010552
171)1821482001054379119136
and1976482001054087135
ocular2130482001054787134152192218
(12367482001052362
study;2447482001053362109157197212
n26784820010547
=27364820010553
49)2800482001054383105
research42549600105266799141180205242288
detected729496001054789116157196225266314
MNPs10584960010568123166198
in1271496001051864
airway135049600105405883148188225
fluids159049600105234490107155186
and1791496001054086133
vitreous194049600105395784110151198244276
humor2231496001054792163209235
respectively,248149600105266799147190229258276315357375413424
with425510001056483111159
links61051000105183784122158
to794510001052773
airway89351000105405985152193231
inflammation115051000105196689112152224297337364383430478
and1654510001054188137
increased1817510001051866106132175214247291341
intraocular218351000105196693119161208249296315355381
pressure.2590510001054976119152185231258300315
ROBINS-E4255240010544104149168224264291334
assessments778524001054073106149182215286330377403438
indicated1235524001051965114132172212239280330
moderate15845240010572120169212238279305347
to1951524001052772
high2043524001054765114161
risk222352400105264577114
of2357524001054670
confounding2447524001053985132155202249296344363410458
and425538001053985131
exposure-measurement571538001054280127174205250274315342413455493525569594635705746792817
bias;1403538001054865103135148
consistency1566538001053983129160177208235275321359399
across1980538001053977102147178210
detection2204538001054789115155194223240286332
modalities25515380010570116164202220237263281322354
was4255520010564104137
limited.588552001051836108126154196245261
Conclusion:874552001055196144184202249281299346394408
Human13085520010555102174214261
in1595552001051865
vivo168655200105405999146
evidence1857552001054383102150193241280322
confirms2205552001053985132155175201274306
that2537552001052774114141
MNPs27035520010569125170202
accumulate425566001054080118164236283302341368410
in857566001051966
multiple9455660010572119138165184232251294
organ1262566001054773121160207
systems1492566001053373107135177249281
and1796566001054087135
are1954566001054066108
associated2085566001054072105153193211251277319368
with2476566001056382110157
inflammation2656566001051865881101502224255800010572112139157204252
and694580001054087136
functional847580001052371118158188206253301341359
impairment.1224580001051890138179197223296339387413429
Methodological16705800010569112140187234283331350397446465504545563
heterogeneity2251580001054790117159185231280323371414432460501
and2770580001054087135
bias425594001054867106138
constrain579594001053985132164192218258276323
causal918594001053979125157198216
inference.115059400105186587130155197244283324339
Prospective1505594001054468114147194238278307326366408
cohort1928594001053985132179205235
studies2179594001053361108155174216249
with2444594001056381109156
rigorous261559400105264593139166211258290
exposure425608001054382131179212258284326
assessment775608001054073106149182215286330377403
and1203608001054087135
confounder1363608001053985133156202249296345388414
control1802608001053985132159185231250
are2077608001054066108
needed2210608001054790134183226275
to2510608001052773
advance2607608001054089129170217257298
understanding425622001054794142185211245273314361409428475523
and967622001054087136
guide1122622001054894113161204
policy.1345622001054997116134174215227
Haemodynamic4256460015385149208311376447509584649754795853
monitoring130164600153102167240281332398458500576639
and19636460015362137208
blood21946460015369108172238310
pressure4256600015370130191245299372434495
management94266000153102167242306370428531590663715
in16796600015339114
severe18166600015351112176235295356
traumatic21956600015351112176247351415466506564
brain4256740015369129193235311
injury:7586740015339114159230291357391
outcomes11726740015364136187246311414473527
from17226740015348109176279
a20236740015362
resourcelimited21086740015359120174241313374434494425688001533980185227278338410
neurotrauma8576880015373132204266332385445509580684748
ICU16286880015340118198
Ishan425709001242973132185244
Gamage169070900124681222082623213741059710007332
1Ishan425729007130453728001212463118166222
Gamage,6967280012165113197245301351371
Consultant10887280012158112167206261284317366421454
Intensivist,1563728001212479112161216255278327351390424445
TH20297280012149115
Anuradhapura,21667280012161116171203252308364412468524556605626
Sri468741001214981105
Lanka594741001214797152199248
Introduction:31876200105196692118164213260300329348395442457
Severe366962001054084124166192234
traumatic39286200105275394140212252279297337
brain428962001054975116135181
injury44956200105186584130156198
(TBI)471862001052367113132155
remains489762001052669141181199246278
a5200620010540
leading526462001051962101150168215263
cause304776001054081127160204
of327776001054771
mortality3374760010572120147178219237256284326
and372676001054087136
long-term388876001051967115163191219261287361
disability42757600105486699140189208227245273315
worldwide,4616760010564111138158206270290338382396
particularly503876001054990116147166206253272312338357397
in546176001051966
low-304790001051965128155
and321890001054087135
middle-income336890001057290138186204247275294340380425497540
countries.392490001053984131177203229248291323339
Prevention427990001054469111150192239265283330377
of467290001054670
secondary475890001053275115160208255295320362
brain513690001054875115133179
injury53319000105196583129155196
through3047104001052774100146193242289
optimization3352104001054796123141213231267309335354401448
of3817104001054670
haemodynamic3903104001054787130202250299338386426498516556
parameters4475104001054989115156228271299340366400
is4891104001051850
a49581040010540
cornerstone5014104001053985111159202228262290336384427
of5457104001054771
neurocritical3047118001054790137163209250276294322340380421439
care.3511118001053980106148163
Although369911800105517097144192239287334
international405811800105196692134160208247274293340387427446
guidelines4529118001054894113161204223241288331364
emphasize49181180010543115163211251284301337379
maintaining53221180010572112131178304713200105276987135153201250
adequate3323132001054089133183230270297340
cerebral3689132001053982108151200227268287
perfusion4002132001054994120147196228247294343
pressure4371132001054976118152185232258301
and4698132001054088137
avoiding4861132001054180127146195214261310
hypotension,5197132001054886136185212255302304714600105335198145161
real-world3226146001052668107126153217264290310358
implementation3602146001051890138158201273316363390430457475522570
of4190146001054770
blood4278146001054968115163213
pressure4508146001054975118151183229255297
(BP)4823146001052468112134
monitoring49751460010572119167185213259285304351399
and5392146001054087136
management30471600010572112159199247291363406453479
strategies354716000105336288129155197246264307340
varies3908160001054081106125168201
considerably,4130160001054085133165183231274300341390409448460
especially4611160001054275123168208226266284303342
in4974160001051865
resource-limited5060160001052668101148196221260301330350368440304717400105184688137
settings.3205174001053376103133152199247279296
There3522174001054190133159201
is3744174001051951
limited3816174001051937108127154196245
evidence4082174001054383102150193240280322
evaluating4425174001054383123142188228255273320368
how4815174001054794158
these4994174001052775118151194
practices5210174001054875115155185203243284317
influence304718800105186588110157200247287328
outcomes3399188001054794122160205278321354
in3777188001051965
such3866188001053379119166
environments.4056188001054390128147173219267339382429456490506
This4586188001054190108140
study4750188001053361108157196
aimed4970188001054058130173222
to5216188001052773
assess5313188001054072105148182214
the3047202001052774118
effectiveness318920200105436693136176206224264307354397430463
of3676202001054771
haemodynamic3771202001054787130202250299338386426498517556
monitoring43512020010572120168186213259285304351400
and4775202001054087135
BP4935202001054488
management50482020010572112159199247290362406453479
strategies304721600105336188128155197246264307340
on3403216001054795
short-term3515216001053279127153183207235276302375
outcomes3907216001054794122159205278321354
in4278216001051865
patients4360216001054889115134177224250285
with4661216001056483110157
severe4835216001053376116158184226
TBI5078216001054187106
admitted5200216001054089161179206236278327
to3047230001052772
a31342300010539
tertiary318923000105276793122140179204245
neurotrauma3449230001054789135160205231257297342413452
ICU.3917230001051867121134
Methods:40662300010568110137183229278309323
A44052300010551
cross-sectional4471230001053964109141173198230273312341359405452491509
analytical4995230001054086125143181211229267307325
study5335230001053360106154192
was30472440010562102133
conducted3195244001053983129176222260289329377
among35872440010539109155202249
3623851244001054283123
adult3989244001053986132149176
patients4180244001054787112130172218243276
with4471244001056280107153
severe4639244001053274113154179220
TBI4874244001054084102
(Glasgow499124400105237593132163210256318
Coma5324244001055094165203
Scale3047258001054181121140183
<8)3251258001055294116
admitted3387258001054089161179207236278327
to3735258001052773
neurotrauma3828258001054891138163210236263303350422462
intensive431125800105186591133180212230271313
care4645258001053979105147
units4813258001054794112140174
at5007258001054067
the5095258001052774117
National5233258001055696123141188236276295
Hospital30472720010555102134181200227267285
of3348272001054669
Sri343327200105406584
Lanka.3532272001053980126163204219
Data3767272001055696122162
were39442720010563105131172
extracted4132272001054280110135176215244285333
from448127200105234995166
clinical466327200105395775121138177217235
records,4914272001052667107152178224256271
including5201272001051864104122167215233279327
demographic3047286001054789160206254279319367413431469
characteristics,3532286001053884123148188227256296322340371399417455488503
comorbidities,4051286001053883154201226274292339357384402444476491
type4557286001052768116159
of4731286001054669
injury,481628600105186481126152193204
BP5035286001054487
monitoring51372860010571118164182209253279297343390
methods,30473000010571113140186232280312327
haemodynamic3389300001054785128198245293331378417487505543
fluctuations,394830000105224489128157203241267285331378409424
management43873000010571110156195242285355397444469
strategies,487130000105336086126151192240258299332347
and5233300001053985132
clinical538130000105385674119304731400105185796114
outcomes.3177314001054692119156201272314346362
Patients3554314001054482108126168214240273
were38423140010563105130171
followed402831400105236987105151213255303
up4346314001054794
to4455314001052772
304542314001054284
days4641314001054887124156
after481331400105396191132157
injury.498631400105186481127152193204
Statistical5206314001054065105130148179207225264303321
analysis3047328001053985124142180212229260
included3322328001051864102120165212254302
descriptive3639328001054789121160185203250276294333374
methods,40283280010571113140186232280311326
chi-square4369328001053884102128160207252291316357
testing474132800105276799127144190237
for499332800105236894
associations,5102328001053971102148188205243269287332379410425
and3047342001054087135
multivariate32043420010572119137165183223264290309348375417
logistic3642342001051966115134166194213252
regression3916342001052668117143185218250268315363
to4301342001052773
identify4395342001051967110157183202225268
independent4685342001051865113157205249296345388435461
predictors5168342001054975117166184224254299326359
of3047356001054770
survival.3139356001053379105148167207248266282
Results:3442356001054588121167186213247262
The3725356001054190133
study3880356001053361108156196
population4097356001054997146193212252278297344391
had4510356001054787135
a46673560010540
mean47283560010572115155202
age4951356001054089132
of5104356001054770
48.2±19.25196356001054387104148201237274287332
years3047370001053981120146180
and3243370001054087135
was33943700010564104137
predominantly3547370001054975117166213286304351391438464483522
male40853700010572112130173
(69.9%).4275370001052364106119160226247260
Non-invasive45513700010556104151179198245283324357375415457
BP5024370001054589
monitoring51293700010572120167185213258285304350399
was30473840010564104137
used3203384001054779122171
in3394384001051865
72.1%3478384001054386101138198
of3695384001054771
patients,3785384001054989116134177224251285301
while41053840010563111129148191
invasive4315384001051865104145177195236278
monitoring46123840010572120167186213259285304351399
was50313840010563104136
utilized518738400105467493111129165207256
in5462384001051966
only3047398001054794113152
27.9%,321639800105438491132198214
reflecting344839800105266891113156196226245292340
resource3805398001052668101149196222260302
constraints.4124398001053985132165193219260278325352386402
Hypotensive4543398001055695145193219261308341359399441
BP5001398001054589
fluctuations510739800105234592132161208248275293340388420
were30474120010564106132174
more32414120010572120146188
frequent344941200105235193142188231279305
than3774412001052774114161
hypertensive3955412001054885135179205235277324356374415457
episodes4432412001054391110142189239282315
(52.8%4767412001052365105120165230
vs5017412001054073
42.3%),511041200105438398142206227240
with5370412001056483110157
a30474260010540
small31044260010532104144163181
proportion3302426001054875121170218244275293340388
experiencing3707426001054281130174200219262309349367414462
both.4186426001054997123171187
ICU4389426001051969124
mortality45304260010572119146176216235253281322
was48694260010564104137
36.2%,5022426001054386102147211228
with5266426001056483110157
an5440426001054087
additional3047440001054088137155183201248296336354
13.3%342744000105437994138202
mortality36544400010572120146177217236254281323
observed4003440001054695128172197241283332
within4360440001056483110157176223
304608440001054386
days4719440001054888126159
among49034400010540112160207256
ICU5184440001051969124
survivors.53334400010533791051481673047454001054086112146162
Significant3225454001054158106153171195214253294340367
associations3608454001054072105152192210249276294341388421
with4045454001056382109156
poor4218454001054896144170
outcomes4404454001054794121159204277320353
included4773454001051865104123169217260309
hypotensive5098454001054785134182209250297329347387429
BP3047468001054589
fluctuations,316246800105234592132161208248275294341389421437
combined3625468001053985158206225272316365
BP4016468001054489
instability,413146800105186598126167215234253271299341352
and4509468001054087136
the4670468001052875119
use4814468001054780123
of4963468001054770
vasopressors,5059468001054081114161210237279312345392419453468
inotropes,3047482001051865113140166212261305338354
and3421482001054087135
blood3576482001054968115163212
transfusions380848200105275494141174198246278296343391423
(p<0.05).4251482001052473125167182225268290303
These4574482001054189133166209
findings480348200105234389138156203251284
likely510648200105193774116135175
reflect530148200105256891113156196226
greater3047496001054874116155182223249
illness331749600105183755102145178211
severity3548496001053376116158184203231272
in3841496001051865
these3926496001052875118151194
patient4141496001054889116134177224251
groups.4412496001054874120167215248265
Positive4697496001054490122140168186227269
fluid498649600105234592110158
balance5165496001054889108147194234276
at5461496001054067
ICU3047510001051868121
discharge318351000105486596135181220245291334
was35325100010563102134
strongly368151000105336086131177225242281
associated3977510001053971103149189206245271311359
with4352510001056281107153
increased4521510001051864102128169207239281329
mortality48655100010572118144173213231248275316
(p<0.001),5196510001052371122163177220264302318331
while30475240010565113132151195
negative3269524001054792142183210229270314
fluid360952400105244694113162
balance3797524001055091110151199240282
was41065240010565106139
associated4272524001054174108156197216257284327377
with4675524001056584112161
improved4862524001051992142169216256300350
survival.5238524001053481107151171212254273289
Patients3047538001054586114133177226253289
with3363538001056585113162
combined3552538001054087162212232280325376
hypotensive3955538001054887138188216259308341360402445
and4427538001054190140
hypertensive4594538001054887138184211242285334368386428472
fluctuations509353800105234694135166215256284303352401434
demonstrated3047552001054892166214263296325351393420463513
the3586552001052876120
worst37325520010564112139173202
outcomes,3961552001054795123162209282326360376
suggesting4364552001053380129178222256285304352401
that4791552001052876117144
haemodynamic4961552001054889132206254304344393434507526566
variability3047566001054080105124163211230248266293334
may33975660010572111149
be3562566001054892
an3670566001053986
important3772566001051889137185211241281328354
prognostic4142566001054874120168215262294322341380
marker.45385660010571111136174215241253
Improvement4807566001051890138164210249291362405452478
in5301566001051864
GCS53815660010555105146
during3047580001054894120139186234
ICU3302580001051970124
stay3447580001053361102140
was36085800010563104137
significantly376658000105325098146164187207246287334360379418
associated4205580001054073105153193212251278319368
with4594580001056483110158
survival4773580001053279104147167207247266
(p<0.001).5060580001052373125167182225270309326339
On54205800010559107
multivariate30475940010572119137165183223264290309348375417
analysis,3485594001054087127145185218236268284
negative3790594001054790139179206224264307
fluid411859400105234592110158
balance4297594001054990108148195235276
at4595594001053966
ICU4682594001051969124
discharge482759400105486698138185225251298341
remained5189594001052669141181199246289338
the3047608001052774118
only3189608001054795113153
independent3366608001051865114157205249297345388435462
predictor3852608001054975117166185224254299326
of4202608001054771
improved4297608001051890139165211251293342
30-day4664608001054385115165205243
survival4931608001053379105148167207248267
(OR5222608001052381126
2.76,5372608001054358100140155
p=0.008),30476220010548101145160202245288309322
while33846220010562109126144186
other3585622001054672118160185
haemodynamic3785622001054685127197243291330376415485503541
variables4341622001053979104122160208226268300
lost465662200105186496123
statistical479562200105325999124142173201218257296314
significance512462200105324996142159182200239278324363403
after304763600105406394136162
adjustment3228636001054088107153185214286329377403
for365063600105237096
confounders.3765636001053985133156202249296345388414447464
Conclusion(s):4248636001055096143183202248280298345393416448468483
Haemodynamic4750636001055595138210258307346394434506524564
instability,533363600105186598126167304765000105496786104131173185
particularly3254650001054990116146165204251269309335354393
hypotension3670650001054785135183210251298331349396443
and4136650001054087136
fluid429565000105234591109158
overload,4475650001054787129155174221262311326
is4824650001051850
closely4897650001053958105138181200239
associated5159650001054073106153193212251278319368
with3047664001056381107154
adverse3216664001053987126167192225267
outcomes3499664001054692119156200271313346
in3860664001051864
severe3939664001053275113155180221
TBI.4175664001054185103119
In4309664001051864
this438966400105267390121
resource-limited452666400105256698145191216253294321340358428446472513561
setting,5102664001053375101130148194241256
fluid537366400105234490107154
balance3047678001054888106145191229270
emerged33326780010542113156181227269317
as3664678001054072
the3751678001052773115
most38826780010571117149177
consistent4074678001053984130162179210238279325350
independent4440678001051864111153201244290337379426451
predictor4907678001054773114162180218247292318
of5240678001054669
shortterm5324678001053379125151180304769200105276792163
survival.3225692001053277102144162201241258273
These3513692001054088130162204
findings373269200105224187134151197244275
underscore4022692001054691138180205238276321346387
the4424692001052773115
importance4554692001051888135182207237276322360400
of4970692001054668
individualized5053692001051864111128167186232278316334351386427474
fluid304770600105234490108156
management32187060010572111157197244287358401447473
and3707706001054086134
early3856706001054381107126164
stabilization4036706001053260100148167185202238278304323369416
of4468706001054669
haemodynamic4553706001054786128200246295334381420492509548
parameters.5117706001054888114154225268295336361394410
Strengthening304772000105416793135182230258306349396414461509
haemodynamic3573720001054787130202250299338386426498517556
monitoring41467200010572119167185213258285304350399
capabilities4561720001054080129169218237255273301319362395
and4973720001054087135
developing5125720001054891131173192239288307354402
context-specific3047734001054088137165208248280305339389435477496521542583
management36577340010574115164206256301375420469497
protocols4181734001055078125153201243290311344
may45527340010574116155
improve4734734001051993144171219260304
outcomes5066734001054897125165212287332367
in5460734001051967
neurotrauma3047748001054790137163209236262303350421461
ICUs3528748001051869123155
in3702748001051865
similar3787748001053250122140159199224
settings.4031748001053376103133152198247279295