933
ABSTRAKTY425200011158114164221282345406464520
Z971200011151
KONGRESU1048200011156116178239299356406466
/1540200011132
CONGRESS1598200011154116177239299355406456
ABSTRACTS2080200011158114164221282345401459509
(LIVES)425320097236080125166206229
Physiology6713200974287124156175220240284330369
is10573200971951
the11253200972671112
only12543200974489109147
polar14183200974691111150177
star1612320097315999126
we17553200975899
have18713200974483121161
–204932009740
unikátní21063200974489108146186213258277
akce24003200973977112152
proběhla25693200974673117163205250269308
již2894320097203974
potřetí29853200974591118144185212231
v323332009739
Praze32893200974268108143184
12217020001113682128
|343200011126
ANESTEZIOLOGIE4268040010753112155200245290342362425467527586607650
A10988040010753
INTENZIVNÍ1172804001071978123168227276296345405426
MEDICÍNA16198040010770114174195248268328382
/20468040010732
Anest21238040010753101145179208
intenziv235080400107196794137185222241282
Med.26528040010770114164180
2026;37(2):116-1252852804001074487128170185230270290333355370407441480510549586630
/35278040010732
www.aimjournal.cz48358040010765133201214257275349367415463490539579598614654693
was425620010563103134
performed57462001054891116141187212284326374
which963620010563109127165211
revealed118862001052667106147186203245293
diffuse14966200105476587113160191233
brain174462001054873113130176
edema193562001054290132203242
and219162001054086133
then233962001052773115161
at251562001054065
day259562001054786123
42732620010543
the279062001052773115
patient42576001054887113130171217242
was681760010563102133
transferred8287600105275291136167190231256281322369
to121176001052771
the129676001052773115
ICU142576001051867120
for15597600105226793
further16657600105237094123169211235
management1914760010572110155194241282352394440465
under239376001054692138180205
sedation261276001053274121160185202247294
with42590001056583111158
propofol,60890001054976122171219243290309323
fentanyl95690001052366113140180227265284
and126590001054188137
midazolam142790001057391139179216262281321393
continuous184590001054086134160178225272319367399
infusion.22699000105196688137169186234282297
Mannitol2591900010570110157204222250295315
was4251040010565106138
also58810400105416092139
administered752104001054190163181228246278307349375417467
and1244104001054088137
sedation1405104001053478127167194212260308
was17381040010564105138
withheld1901104001056583111159206250268317
after224310400105416495137163
482431104001054388
h25441040010548
to2617104001052874
allow271610400105415977125189
for42511800105236994
assessment543118001054072104146179211281324370396
of963118001054769
the1056118001052774116
neurologic1196118001054790136161206225271319337375
status.1595118001053361100126172204219
Myoclonus18381180010569107153192210256303349380
was22421180010564103135
evident2401118001054382100147190236262
within2686118001056482109155173219
15425132001054380
minutes,529132001057391138184211253285300
sedation854132001053376125164191209255303
was11811320010564105137
reinitiated134313200105266885132150177195234260302350
and1718132001054087135
valproic187813200105408098147173218237276
acid217813200105418098146
as2348132001054073
a24451320010541
continuous2510132001054085133158176223269316363395
infusion42514600105186487134165182228275
was7201460010564103135
added875146001054088135177226
along1121146001054057104151198
with1339146001056482108155
an1514146001054086
increase1620146001051864103128170208240282
of1922146001054770
levetiracetam.2012146001051961100141168185210250289330356396467482
The2514146001054189131
following266514600105236988105151214425160001051864112
days558160001054887124156
as735160001054072
guided828160001054893111158200248
by1097160001054987
neurologic1205160001054789135160205224270318336374
consultation,1600160001053984131162208225252291317335381428442
antiepileptic2063160001054086112129171219237254297344371388427
medication25111600010572114162180218258284302348394
had425174001054786134
to576174001052772
be665174001054992
titrated7741740010527457297137163203252
until1043174001054793118136153
day1214174001054786124
231355174001054385
due1457174001054894136
to1610174001052772
persistent1699174001054992117150167198226266313338
myoclonus20541740010572109155195212259305351382
activity2454174001054079107125164183209250
up2721174001054795
to2833174001052772
levetiracetam425188001051961100141168185210250289330356396467
6g,910188001054392106
valproic103418800105408098145171216234272
acid132518800105407996143
4g,1487188001054391106
clonazepam1611188001054057104150189225266314354425
3mg,20541880010543113161176
lacosamide224818800105195796141173213284302349391
200mg2658188001054384128200248
and425202001053985131
perampanel570202001054891115154224271310355397414
8mg.9982020010543113160174
He1186202001055596
also129620200105395787133
received1442202001052667105145162201241289
continuous1744202001053983129154171216261306352383
infusion214020200105196485132162179224270
of2424202001054668
1.5mg/kg/h250620200105425294163209240277322353399
ketamine425216001053778104144215232277320
for75921600105236894
24867216001054381
hours962216001054794140165197
to1173216001052872
allow125921600105405875121183
for145721600105236893
therapeutic1565216001052773115140180227270316342360398
levels1977216001051961100141159189
of2181216001054669
the2264216001052774116
accompanying2394216001054079115160231279318364401419465512
treatment.42523000105275293131156227269315340355
Management7942300010568107153192239280351393439464
of1272230001054769
antiepileptic1355230001054086111128170217235252294341367384422
medication17912300010572114162179217256282299345391
was21962300010564103134
based2344230001054988120162209
on2567230001054793
clinical267423000105395774119136174214231
manifestations4252440010572111157175197239271299338364382428475506
of947244001054770
myoclonus10332440010572109155194212258305351382
due1431244001054894136
to1583244001052772
lack167124400105195897133
of1820244001054770
portable1906244001054896121151190238256299
EEG.2221244001054180134150
Results:2387244001054587119165182209242256
On26592440010559106
day2782244001054887124
23425258001054385
of528258001054769
hospitalisation615258001054794126173191218258275293324364390407453500
the1133258001052774116
patient1267258001054888114132174220245
status1530258001053361100126172204
allowed175125800105405876122184226274
for204325800105236994
his215525800105486596
transfer226925800105275292139170194235260
to2547258001052772
the2637258001052774116
EEG2771258001054180134
laboratory425272001051958105152178218244288314355
where7962720010564111153178219
despite1031272001054891123170188215255
demonstrating1302272001054891162208255287314340379405423469516
myoclonus,18342720010572109155195212259305351382397
this224727200105277491122
was23852720010564104135
not2536272001054794120
associated2672272001054072103150190207425286001054066106155
with596286001056482109155
epileptiform768286001054290108126168215242259282328353425
abnormalities1210286001054087134181206278317335352379396438471
in1697286001051965
the1778286001052874116
EEG.1911286001054181135151
The2078286001054189132
EEG2226286001054181135
performed2377286001054992117143188214286328376
was27702860010564103135
asymmetrical,425300001054072111183254297323349367405445463477
with923300001056482109155
θ11003000010545
waves11673000010563103141182214
in1403300001051965
the1489300001052774116
left162730000105196183113
hemisphere,1762300001054790161178209257304346371412426
lack220930000105195897133
of2364300001054769
basal2455300001054988120160178
activity2655300001054079107125164183209250
was4253140010564103135
recorded580314001052667107151177223265314
in914314001051864
the998314001052773116
other1134314001054772119161186
hemisphere1340314001054790161178210257304346371413
and1772314001054087134
myoclonic19263140010572109155194212258305322361
status2307314001053360100125172203
epilepticus2530314001054390108126168216242260298344375
of425328001054770
cortical519328001053984110140158197237254
origin79832800105477291138156202
was10243280010564104136
excluded.1184328001054381119137183231273322337
Gradually,1545328001055581121169215254272289328338
the1908328001052774116
frequency204832800105245092140186228275314355
of2427328001054770
myoclonus25213280010573110156195213260307353385
decreased425342001054890130155196234266309357
and798342001054086134
antiepileptic948342001054086112129171219237254297344370388427
treatment139134200105275394132158229272318344
was17513420010563103135
reduced1902342001052667115161200241289
to2207342001052772
2.4g229534200105435799148
valproic245934200105408097145170216233272
acid,274734200105407996144158
lacosamide42535600105185695138170209279296342384
100mg,822356001054380123194241255
clonazepam1090356001053956102148186221261308347417
1mg,15203560010543108154168
perampanel1702356001054891115154224271310355397414
8mg21303560010542113159
and2303356001053985131
levetiracetam244835600105196098139164182206245283323349387457
4g.425370001054392107
No5513700010556103
ECG674370001054190141
changes834370001054086125171218261293
were11463700010564106131172
recorded1338370001052567106151177223265313
during1671370001054893118136182230
the1921370001052773116
course2056370001053984131156188231
of2306370001054770
treatment.239537000105285394133158230272319344359
The2774370001054189131
patient425384001054888113130172218243
died682384001054865106154
after85038400105406291132156
581021384001054283
days1118384001054886123155
of1287384001054769
hospitalisation1370384001054793125172189216255272289320360385402448494
due1878384001054893135
to2027384001052771
complications2113384001053983154201219236274313339356402448479
of2606384001054769
sepsis.2689384001053375122154170201217
Conclusion:425398001055094141179196241272289335381395
PHM834398001054497164
can1012398001053978124
be1150398001054891
a12553980010540
challenging1309398001053985123141158199245292309355402
phenomenon1725398001054895137183229300342388434480
that2219398001052773112137
occurs2370398001054786123168193225
after260939800105406291132156
cardiac2780398001053978103425412001054865104143
arrest.58241200105406591132164191207
EEG803412001054181134
data952412001054887112152
may11194120010572111148
not1281412001054794120
be1415412001054992
indicative1521412001051965112130168208233251290332
of1867412001054770
clinical195141200105395774120137176216233
manifestations21994120010572111157174197239271298338363381427474505
while27194120010563110127145187
thorough,425426001052774120146191237285331345
step786426001053361102149
by951426001054987
step1054426001053360101149
titration12194260010527457197137162180226273
is1508426001051950
necessary1574426001054790129170202234274299340
to1930426001052872
manage20194260010572111157196243286
such2321426001053378117163
demanding2500426001054890161200247294312358405
and425440001054086134
persistent576440001054992117150167198225266312338
cases.931440001054079111154186201
Cardiac4254640015377141203275316381438
conduction8864640015357122196266338395448489554627
disturbances15364640015369111165218290352421485560618678732
following22914640015347111150192256350392467531
high-dose4254780015372114178252289361425479540
antiepileptic9884780015362137189229289359399441500570623663722
therapy17324780015351125184245308378441
for21954780015348112172
refractory4254920015359120169230294351405471531596
status10444920015351104168219291344
epilepticus:14114920015359129169211270340393433492565618652
a20864920015362
case21704920015357121175236
report24294920015359120191257317372
Alexandra425513001246693147200252312372410463
Tsankof1,908513001245593147206261318352126151400733212925130012426
Anna13385130012466124183237
Gkiouliava1,15955130012468124153211270298326379431484207351400733221045130012426
Georgios4255260012468122181220279307365409
Tziomalos1,854526001245596125183270323351410453130452700733213355260012426
Giannoula1381526001246897150210269327386414467
Thoma1,18695260012454113172258312217552700733222065260012426
Ioanna425539001242987140200259312
Soultati1,7575390012454113172200237291328357111054000733211425390012426
Aikaterini1188539001246693148202238292331358417445
Efthymiou1,1653539001245489128188239326354412471212054000733221515390012426
Helena4255520012469123151205264318
Argiriadou176355200124661041631912292573103704294881247553007332
1Department4255720071304535710012167118175223256292375425481513
of988571001215584
Anaesthesia10935710012161116164215254288343394433456504
and16185710012148104160
Intensive1799571001212480112161217256279327376
Care,21965710012158107139189209
School2426571001215095150205261285
of2732571001215584
Medicine,4685840012180131188212256279335385405
Faculty894584001214993138193216249299
of1214584001215584
Health13195840012166116164188221276
Sciences,1616584001215095118168224269318357378
Aristotle2015584001216294118157191245277301351
University23875840012165120143191240273314336370419
of468597001215584
Thessaloniki,5735970012150106157196235284308363419442488513534
Greece1128597001216498148199244293
Background:565622001054485125162209235281328375423438
The1019622001054190133
management11686220010572112159199247290362406453479
of1663622001054771
refractory175062200105266891118159199228274300342
status2109622001053261101128175207
epilepticus2332622001054392110129172220247266305352384
(RSE)2732622001052468110149174
often425636001054770101143190
requires640636001052668117164182208250283
high948636001054765114161
doses1134636001054795128171204
of1363636001054770
sodium-1458636001053381130148194266294
channel1777636001053986126173220264283
blocking2085636001054868115155192212259307
antiepileptics.2418636001053987113131174223242260303352379397437471487
While4256500010572120138157200
effective64365000105436693135176205224264306
for96765000105237096
seizure108165000105337695131178204246
control,1345650001053985132159185231250265
these1628650001052774118151194
agents,1840650001054088131179205239255
particularly2113650001054889115145164203250268308334353392
phenytoin,2523650001054997140187225255301320367382
are425664001054066108
associated550664001054073106153193212251278319368
with936664001056382110157
significant111066400105335199146164188207247287334361
cardiotoxicity.1488664001053980106153171218245291328347387405432474486
We19916640010572113
report2122664001052668116164191221
a23606640010540
case2418664001053980112156
of2591664001054770
severe2679664001053276116158184226
cardiac425678001053979104150168207246
conduction686678001053984130178223262291309355402
disturbances110467800105476596124170195243283330368409442
and1561678001054086133
hemodynamic1710678001054689160206254293340379450468507
instability223267800105186496124163211229247265292332
following258067800105236887105151214232278325
the425692001052775119
administration570692001054089161180227245278306333374401420467515
of1111692001054771
a12086920010540
multi-drug12746920010572119138166185212263289337385
antiepileptic1685692001054088114133176225244263306355383401441
regimen.2152692001052669118137209253300316
Methods:24946920010569113141188236285318333
A28536920010552
79-year-old425706001054384113152195234260284333353401
female850706001052366138178196239
with1113706001056483110158
a12957060010540
history135970600105476597126171198240
of1623706001054771
meningioma17187060010572115162180227276294341414454
resection2196706001052668101144184214233280327
presented2547706001054975118151194241267309358
with425720001056382109155
focal-to-bilateral596720001052369109149167194221266294343362380419445486512552570
tonic-clonic1182720001052772119137176198239257304351368407
SE.160572000105408095
Initial171672000105186583110128167185
management19177200010571111157196244287358401447473
included2406720001051864104122168215258306
4g2728720001054392
of2835720001054770
levetiracetam,425734001051961101143170189214255294336363403475490
20mg931734001054385157206
of1153734001054670
diazepam,1239734001054866105141183231272344359
and1614734001054087135
250mg1765734001054386127200248
of2030734001054670
phenytoin.2116734001054896139186223254299317364380
Due25127340010557104147
to2675734001052773
persistent276473400105489211842574800105325081109149196221
seizure66274800105327492127174199240
activity,917748001054079108125165183210251262
the1194748001052773116
patient1325748001054888114132174220246
was15867480010563102134
intubated173674800105186489135183223249289337
and2089748001053985133
started2237748001053260100125155195243
on2496748001054693
propofol2604748001054874119167214237283301
and425762001054088137
remifentanil588762001052769142161185228276303344392410429
sedation.1043762001053377127167195213261309326
Upon13957620010556104153202
Intensive162376200105196693135183216234275318
Care1967762001055192119161
Unit21557620010555103121149
(ICU)233076200105244294149172
admission,2529762001054089162181213247265312361376
an425776001054087
additional538776001054089138156184203250298338357
dose921776001054895128172
of1119776001054770
phenytoin1215776001054997141188226257303322369
was16107760010564104137
administered,1773776001054089161180227245278306348374417466481
and2280776001054088136
maintenance24427760010573113131178205247294334382422463
therapy304762001052775119146187236275
with334862001056484112160
levetiracetam353462001051962103146173192218260300342370411484
(1g404462001052463107
BID)417762001054564122144
was4347620010564105138
initiated.45126200105186684112131171198240290306
Empirical4844620010542114163182209228268309328
coverage519862001054086126169196237286330
with304776001056482110157
ceftriaxone322676001053981104135161180220259305353396
and364476001054087135
acyclovir380176001054080121160179226265284310
was4133760010564104137
provided429276001054875121160179228271320
due463476001054894137
to479376001052773
a4888760010540
recent495076001052668108150197223
history51957600105476698126172198240
of545776001054771
a3047900010540
vesicular311390001054082115133173220238278304
rash.34439000105266799146162
Results:363190001054488121167186213247262
Within391990001057292120167185232
hours417790001054795142168202
of440490001054771
ICU450190001051869123
admission465090001054089161179211244262309357
and503390001054087135
following51949000105237089108155219238285333
antiepileptic3047104001054087113132175223242261304352379398437
loading,3502104001051966107155174221269284
the3804104001052875118
patient3940104001054990116135178225251
developed4209104001054891131173192240289333382
nystagmus4609104001054785118146187235307354386
and5013104001054087135
significant516710400105325098145164187207246287334360
QTc3047118001055999133
prolongation,3204118001054975121140188235284323350369416463478
progressing3706118001054975121170196238271304322369417
to4147118001052773
long4244118001051966113162
QT4430118001055998
syndrome4552118001053373121170196242314358
accompanied4934118001054079117163235284325372390433482
by5440118001054887
acute3047132001054080126154196
hemodynamic3265132001054791163210259299347387459477517
instability.380413200105196598126167215234253271298340352
Despite41781320010557101134182201229270
initial447113200105186583111129169187
stabilization,4681132001053361102150169188206242283310328375423438
the5141132001052875118
following5282132001052369891071542183047146001051865114
day3181146001054888126
the3327146001052875118
patient3466146001054889116134177224251
manifested37371460010572112159177201243276305347396
transient415314600105275494141174192235282308
Mobitz44821460010568116165183211249
Type4751146001054175125169
II4940146001051937
atrioventricular499814600105406693112159198240288314340359399445464504529
block.3047160001054867114153190207
A32701600010551
temporary3337160001052768139187234260300325367
transvenous372016000105275293139171211253299346393424
pacemaker4160160001054888127168240279316357383
was45581600010563103135
inserted;470916000105186496139164194235283298
however,5022160001054794156198237279305316
sinus535416000105325096142173
rhythm3047174001052674111142189261
was33261740010564104137
restored3480174001052669102130176202244293
within3791174001056382110157175222
the4031174001052774118
next4167174001054790129159
hour.4344174001054794142167180
The4541174001054190133
patient4692174001054989116135177225251
was49611740010563104136
successfully5115174001053379119157198231264289336355373412
weaned30471880010562104142188230277
from333918800105234994165
mechanical35191880010571113152198237282300338377395
ventilation3929188001053981126152169187226251269315361
and4305188001053985132
vasopressors,4452188001053979110156204230270302334380406438453
and4920188001053985132
subsequently5067188001053277124156198246291333379404422460
transferred304720200105275393140172196238263290331380
to3442202001052773
the3531202001052773116
neurology3663202001054790136161207226272321360
ward.40392020010563103129175191
Maintenance42462020010568107125172197239285325371410452
therapy4713202001052774117143183231269
continued4998202001053984131157175221267310358
with5372202001056382109156
phenytoin3047216001054996140187225255301319366
(125mg343021600105236299142213261
TID)3708216001054160117139
and3863216001054087136
levetiracetam4015216001051962102144171190216257296338365406478
(1.5g450921600105246273117164
BID).4690216001054463120142155
Regrettably,4861216001054488137163205232262303351370410421
on5299216001054694
the5410216001052774117
38th3047230001054386115162
hospital3235230001054895129177196224265284
day,3545230001054888127138
the3709230001052775119
patient3854230001054990117135179226253
died4133230001054866110159
due4318230001054895139
to4483230001052773
septic4582230001053377126153172211
shock4819230001053381128169207
and5052230001054087136
multi-organ521423000105731201381661852122622893047244001054889137
failure321024400105236584102150176219
caused3455244001053981128161205254
by3736244001054988
a38502440010541
multidrug-resistant39172440010573120139167186234261309358386413456489508540569610658685
Gram-negative4628244001055683124197225274318368408435454495538
infection.519224400105196690133174204223271319335
Conclusion:3047258001055096144183202248281298345393408
This3471258001054190108140
case3628258001053980112156
highlights3800258001054866114161179198246293319353
the4170258001052774118
critical430425800105396584112130170210229
need4550258001054790134183
for475025800105236996
continuous4863258001053984132158177224270318365397
cardiac5277258001053980106153171211250
monitoring30472720010572120167185213259285304351399
during3463272001054895121140186235
the3715272001052774118
aggressive3850272001054088137162205238270288328371
treatment423827200105275395135161234277324351
of4606272001054770
SE.469327200105418197
The4807272001054190133
synergy4957272001053373121165190238277
of5251272001054771
highdose53392720010547651131603047286001054894127170
antiepileptics3233286001053986112130173221239257300348375393432466
can3715286001053979126
trigger385728600105275371119167210235
life-threatening410828600105193660102130157204229271310336377424442488536
arrhythmias466028600105406692139176207254325343382414
and5090286001054087134
conduction5240286001053985132180226265304730000105274591138
blocks,3201300001054867113153189224240
even3456300001054282123170
in3641300001051865
patients3721300001054888114133175221247280
without4017300001056381108155202248275
prior430830000105487492138164
cardiac4488300001053979104150168207246
history.475030000105466496124168194236247
Clinicians501330000105496785131149188205244290322
must53513000010571117149177
remain3047314001052668140180198245
vigilant3309314001053958107125143183230256
for358231400105236996
iatrogenic369431400105195885111157206249296315354
cardiotoxicity,4064314001054080106153172219245291328347387405432474486
as4566314001054073
these4655314001052774118151194
complications4865314001054085158206226244283324350369416463496
may53773140010572112150
necessitate3047328001054790131172205238256284324351392
invasive3459328001051865104144177195235277
interventions.375632800105186591133159202244292318336383431463480
Predicting30473520015371133194265307365419459535598
the36683520015351125184
impact38753520015338143213276334387
of42853520015364112
mechanical442035200153102161220293358433474533596638
ventilation30473660015362122195246286328392443483549622
on36923660015363137
central38513660015357117190242302366408
venous42813660015362122195259332385
pressure46893660015370130191245299372434495
Ivelin3047387001242982133162190249
Karageorgiev1,33163870012462115154206265319378416475503557609392438800733246
3,398238800733340163870012426
Ralitsa40623870012459113141169206251305
Petrova1,43873870012458110147186245297350473038800733246
3,478838800733348223870012426
Sevil30474000012454107160188216
Ahmed-Shieva1,32834000012466124210264325359411470498552604657393440100733239654000012426
Vasil40114000012464114158186214
Popov1,42454000012458115175234286453040100733245614000012426
Aneesha46074000012466124178232276335389
Bhambra2,50164000012460119173259320358411542740100733254614000012426
Ivaylo3047413001242982135186214272
Minev2,33394130012485114173226279361741400733250
33678414007333
1Technical30474330071303075432001215094139194249273317366390
University34864320012164119142191240273313336369419
of3926432001215584
Sofia,40314320012150105134160208229
Plovdiv4281432001215476131178234257305
Branch,4607432001215587136191236291312
Bulgaria49404320012154109133189237270293341
2Medical304744600713030784450012180131188212256305329
University34284450012164119142191240273313336369419
of3868445001215584
Plovdiv,3973445001215476131178234257305321
Bulgaria43154450012155110133189237270293341
3Center304745900713030784580012158107163195244277
for3376458001213085117
Competence35154580012158111195252303336385441486535
PERIMED40714580012153101154179259309375
2,4467458001215172
Plovdiv,4560458001215375130178233256305320
Bulgaria49024580012154109132189237269293341
Background:3187482001054484123159206231276322368416430
Mechanical36394820010568111150197236282299338377395
ventilation4056482001054082128153171189227253271317364
could4442482001053984130148195
affect466048200105396288129169198
the4880482001052774116
central5018482001054080127152177217235
venous5275482001054081128174221252
pressure3047496001054974115147179224249291
via335649600105405897
changes3472496001053985124170218260292
in3783496001051965
intrathoracic386649600105196590116155181228274300340378396434
pressures.4319496001054974116148180225250291323339
Objective:46764960010559108126168207236254293335349
To5043496001054182
predict5144496001054974116164181220249
the5411496001052774116
transmission304751000105275291137168238256286318334380426
ratio348851000105256590107153
of3655510001054769
the3738510001052773115
airway386751000105405782147186223
pressures4104510001054873114146177222247287319
changes4437510001053985123169216258290
on4741510001054693
central4848510001053979125150175214232
venous5094510001053980126172218249
pressure53575100010549741141463047524001053378103144
(CVP).3206524001052371117162183195
Methods34155240010569111138184231279310
and3740524001054086133
analysis:3888524001054086125143181214231262276
A41785240010552
retrospective424552400105256793118164196243286326354372411453
analysis4712524001054087126143182214231262
of4989524001054769
mechanically50735240010572114154200239285303341381399416454
ventilated3047538001053979124149166182220245284331
patients3391538001054887112128169214239271
from367553800105234892162
the3850538001052772113
AmsterdamUMC39765380010551121151178217241286324393446511559
ICU4548538001051967119
database4680538001054785110148195233264305
was49995380010562100131
conducted.5144538001053882127173217255283322369383
For3047552001054084108
each3168552001054279117161
patient,3343552001054786110127168213237251
variables3607552001053978102119156202220260291
describing3912552001054687118156180197243260305351
mechanical42765520010570112150194232277293330369386
ventilation4675552001053979124148165181219244260305350
(PEEP,5038552001052365103141182185
DP,5236552001055698101
PPlat,5351552001054384100137162176
I:E304756600105193373
ratio,313756600105266691109155169
RR,3322566001054589105
VT,3443566001054590100
PAW3559566001054490158
mean)37335660010572115153200220
and3969566001054086134
CVP4119566001055197142
were42775660010564106131172
extracted.4465566001054381110136175214243284332347
These4829566001054188131163205
sub-sets5051566001053378125153186228255288
were53555660010564106131172
used3047580001054778121169
to3232580001052772
determine3319580001054891117158183255272318361
optimal3695580001054795122139210249267
combinations3978580001053984156203221267306332350396442474
of4468580001054769
input4553580001051965112159185
features4754580001052365103129175200241274
for504358000105236995
identifying5154580001051865107154179197219261280326373
nonlinear3047594001054794140158175221264302327
patterns.3389594001054888114143184209256287303
Exclusion3706594001054181118136181213230276323
criteria404359400105396483109150175193232
for428959400105236994
the4398594001052774116
factors4529594001052363102131175201234
compromising4777594001053984156203229274346363394411457505
the5296594001052874116
accuracy54275940010540793047608001053984108147185224
of3285608001054668
central3366608001053979124149173212230
venous3609608001053980125170216246
pressure3869608001054873113144175219243284
measurements41666080010571113150181225250290360401446471503
were46836080010563103128168
applied.4864608001054086133151168209256270
We51486080010571110
applied5271608001054086133151168209256
XGBoost3047622001054798140186232263290
as3350622001054070
a34346220010539
predictor,3487622001054872112159176214242285310320
for382162200105226792
its392662200105184476
interpretable401662200105186388127152199223264289328374392433
decision4463622001054788126143173190235280
tree475762200105275191133
characteristics4904622001053883121146184222250290314331362388405443475
that5393622001052672110135
captures3047636001053977124149194219259290
non-linear3351636001054692137163182198243284322346
relations371163600105256683121146163208254284
well,40096360010562103120137150
as4173636001053970
it4257636001051844
harnesses4314636001054785109155196228259300331
methods46596360010571112138183229276307
to4979636001052771
mitigate5063636001057188114131177215240280
overfitting535663600105468412514930476500010523426897115161208
while32746500010564111128145188
training.348165000105275292110156173219266281
It3781650001051945
optimizes3845650001054795121139210227262303335
a41996500010540
global4258650001054866112160200218
objective4495650001054795113155194223241280321
function4835650001052371117156184202248295
combining5149650001053984155203221267284330378
a30476640010540
loss310266400105186597128
term324566400105276893165
and3425664001054086134
regularization3573664001052668116161179218243261296337362380426473
to4061664001052772
control4147664001054084131157182227246
model44076640010572119167210228
complexity.4649664001054084156204222264302320347388399
Using5063664001055585102148196
second5273664001053376115160207254
-30476780010526
order3091678001054672118161186
gradient,3294678001054873113160178220266292307
tree361867800105275294137
splits377267800105338099116142176
are3965678001054065106
selected408967800105327593135175203244292
to4399678001052772
maximize44886780010572111149167238256291332
loss483767800105196597129
reduction4983678001052668116161200229247293339
while53406780010563110127145187
maintaining30476920010572111129175200240257303320366414
regularization.3484692001052567115161178217242260295336361379425472487
Trees3994692001054060102145177
are4193692001054065106
sequentially4322692001053375123169211258283301339357374413
added4757692001054088135178226
with5005692001056482109155
a51836920010540
learning524569200105196199124171189235282
rate304770600105266692132
to3194706001052772
ensure3281706001054289120165190231
stable3527706001053360100148166208
model37507060010572119167209227
improvement3992706001051889137162207246287359401447473
and4479706001054087134
strong462870600105336085131177225
generalization.4868706001054790136178203243261278313354379397443490505
As5388706001055185
a54877060010540
cross-reference3047720001053964108140171195221262284325349390436474514
means35757200010572114151197228
to3817720001052771
study3902720001053360105152190
the4106720001052773115
generalization4235720001054789135176201240258275309349374392437483
properties4732720001054874118166208233262279321352
and5098720001054085132
mitigate5244720001057289115132179217243283
overfitting3047734001054785127152177196223252269315363
with3433734001056482108155
XGBoost,36117340010548100143190237269297312
a39467340010540
two-stage4009734001052893139166199226266313356
predictor4388734001054974115163181219248293319
is4730734001051850
set4803734001053375101
in4928734001051864
a50157340010540
series5079734001053375100118160192
of5295734001054669
four5387734001052369115140
ensemble3047748001054390123166238287306349
based3420748001055090123166215
learners:3660748001051861101126174217243276291
XGBoost,39757480010549102146194242275303318
LightGBM,4318748001054058106153179236280349365
CatBoost,4707748001055192118162210258290319334
and5066748001054087136
Random5226748001054586133181228301
Forest3047762001054186112153185212
to3283762001052772
lend3379762001051961107155
insights355776200105196596113161207232265
for384676200105236994
change3964762001053986125171218261
in4248762001051965
performance4336762001054992117143188214286325371410451
and4811762001053986133
narrow4968762001054786111137182245
the5236762001052874116
best5376762001054992124152
performing3047776001054992117142188214285303349396
method.34597760010573115141188234283298
Results3773776001054486119164182208241
and4030776001054087134
Discussion:4180776001055775106145191222254271317364378
The4574776001054189131
evaluation4721776001054382122139185224250267313360
benchmarks5097776001054992138177223294333358395430