1019
ABSTRAKTY3363200011158114164221282345406464520
Z3909200011151
KONGRESU3986200011156116178239299356406466
/4478200011132
CONGRESS4536200011154116177239299355406456
ABSTRACTS5018200011158114164221282345401459509
(LIVES)2480320097236080125166206229
Physiology27263200974287124156175220240284330369
is31123200971951
the31803200972671112
only33093200974489109147
polar34733200974691111150177
star3667320097315999126
we38103200975899
have39263200974483121161
–410432009740
unikátní41613200974489108146186213258277
akce44553200973977112152
proběhla46243200974673117163205250269308
již4949320097203974
potřetí50403200974591118144185212231
v528832009739
Praze53443200974268108143184
|5584190011126
119565419001113676124
/23748040010732
Anest24518040010752100145178207
intenziv267880400107196794136184221240282
Med.29798040010770115165181
2026;37(2):116-1253179804001074487129171186230271291334356370407442481511549587631
/38558040010731
ANESTEZIOLOGIE39528040010753112155200245290342362424467527586607650
A46248040010752
INTENZIVNÍ4698804001071978123168226276296345405426
MEDICÍNA51458040010770114174195248268327381
www.aimjournal.cz4258040010765133201214257275349367415463490539579598614654693
Hyponatremia425580015385147220286359423474535596699740805
and1253580015362137208
fluid148358001534893165206277
shifts1782580015352126167219273327
in2131580015339114
diabetic2268580015369111176245306359399457
hyperglycemia;425720015372134207268328392433494551612715756821857
secondary1304720015352113171237310380445507572
analysis1899720015362138202244305359400454
of425860015364112
a560860015362
prospective645860015370130196250321382440494534596656
clinical132486001535696137213254313376418
trial1765860015351112154219260
Robert4251070012459117178231271309
Svensson,7551070012454105156216260304362421448
Robert12231070012459118178232271310
G.1553107001246896
Hahn,16691070012469123182241268
Joachim1957107001244199153198258285372
H.2349107001246997
Zdolsek24661070012457117176204248301357
Abstract5651320010551100133162188229268298
Background:881132001054485125162209235281328375423438
Hyponatremia1337132001055594144192240280306332375447465504
is1859132001051850
a19271320010540
common1985132001053984157229277324
feature2327132001052365105131178204246
of2591132001054770
severe2679132001053376116158184226
hyperglycemia425146001054887138183210258277318358401474493534
in986146001051867
diabetic1079146001054968109159204232251292
patients.1398146001054991118138182230257293310
We17341460010574116
studied1877146001053362111160179224274
whether21781460010564113158186234279306
it2511146001051847
is2584146001051952
due2663146001054996141
to2831146001052774
plasma425160001054968108140212252
dilution,69716000105486685131159177224272287
a10051600010540
sodium1065160001053380129148194266
deficit,1351160001054891115134173192219235
or1606160001054774
both.1700160001054997124171187
Methods:19071600010569112139187234283315330
In2258160001051865
172344160001054279
patients2443160001054889116134177224251285
with2748160001056483110157
diabetes-induced425174001054867107157202229272305332352399448496536578628
severe1080174001053377117160187230
hyperglycemia,1336174001054886137181208256275315354397470489529545
blood1907174001054969117166216
hemoglobin2149174001054892165213263282330380399447
and2622174001054188138
the2786174001052775119
concentrations425188001054086135176218266293320362389408456505538
of990188001054771
glucose,1088188001054867115155202236280295
sodium,1409188001053382132151198272287
and1723188001054088138
other1887188001054875124168194
electrolytes2108188001054363107148178205252272312344386420
in2555188001051866
plasma2648188001054969109143216257
and425202001054087135
urine58620200105477291138182
were7932020010564106132174
measured9932020010572115154187233259301350
during1369202001054794120139186234
and1628202001054087136
after178920200105406394136162
an1976202001054087
intravenous208920200105186591118158197240287334381414
infusion252820200105196588136169187234281
of2835202001054770
14252160010543
L4922160010539
of555216001054771
0.9%65021600105435899165
saline83921600105337492110157201
over1064216001054686128154
301242216001054386
min1352216001057290137
on1513216001054794
two1631216001052793140
consecutive1795216001053985133165208249295323342382424
days.2243216001054888126159176
Fluid2442216001054159105124172
volume2638216001053986105152224267
and425230001054088136
electrolyte587230001054362106147176203249269308339381
kinetics994230001053858105149176195235269
were12892300010564107133176
applied1491230001054089138158176219268
to1785230001052874
study1885230001053361109158197
relationships210823000105266988128155174221269302349367416449
between2583230001054993121187230275322
the425244001052774118
glucose561244001054866113152198231274
and853244001054087136
electrolyte1007244001054261104145174201247266305336378
levels1403244001051861101144162194
and1615244001054087136
to1769244001052773
estimate1860244001054276104122194234261302
the2181244001052774117
sizes231624400105335187129162
of2496244001054770
the2585244001052774117
body2720244001054997146186
fluid42525800105234591110158
compartments.602258001053984157205246272302375418465492526542
Results:1163258001054488121167185213247262
There1443258001054190133159201
was16632580010563104137
a18182580010540
statistically1877258001053261101128147179207226265306324342382
significant227725800105335199146164188207247287334361
inverse2656258001051966104147173206249
linear42527200105193784127166192
relationship63727200105266887127154172219267299346364413
between1070272001054993120186229272320
plasma1410272001054968108140212252
glucose1682272001054867113153198231275
(highest197727200105237189137184227260289
value228627200105408199146189
532495272001054384
mmol/L)25992720010572144192211243283306
and425286001054087135
plasma580286001054868107140212252
sodium851286001053380129148194266
(lowest113628600105234390153196229257
1201413286001054379121
mmol/L).15542860010572144191210242282306319
The1892286001054189133
correction2044286001053985111138180220250269316363
factor2427286001052364104133179205
was26522860010563104137
1.6280828600105435497
or425300001054672
2.2513300001054257100
depending629300001054790137181227275292338386
on1030300001054794
how1139300001054793156
the1310300001052774116
comparison1442300001053883155202242268286317364411
was18683000010563103135
made.20183000010572111158201215
The2248300001054189131
hyperglycemia2395300001054683132175201247265303342382453471510
on425314001054693
admission534314001054088159177208240258304351
corresponded901314001053984110136178210258305352400442491
to1408314001052672
a14953140010540
fluid155131400105224490108155
shift172231400105337996120150
from188831400105224995166
the2070314001052774116
intracellular220231400105186590116156196237255273319337376402
space2619314001053380121160201
of2835314001054770
350425328001054383124
mL,5653280010571110126
which7073280010563110128167213
was9363280010563103135
sufficient1087328001053277101127146185203245292317
to1420328001052772
explain1508328001054280129148187205251
the1775328001052773116
difference190732800105476588114156182223270309350
in2273328001051864
baseline2353328001054888120163181199245288
plasma2657328001054867106138209248
sodium425342001053380129148194266
between710342001054993120186229273320
the1049342001052774118
two1186342001052793140
study1345342001053361108157196
days.1560342001054888126159176
However,17553420010555103166209249291317329
this210334200105277492125
dilution224734200105486684131158177224272
co-existed2538342001053985113158197216248277318367
with425356001056382110157
a5983560010540
20%654356001054385151
reduction821356001052668117164203233251298346
of1183356001054770
the1269356001052875118
plasma1403356001054968108140212252
and1671356001054087135
extracellular1822356001054382112138179218260279297343361401427
fluid226535600105234591110158
volumes,2439356001054086105152223267300315
and2771356001053986135
the425370001052773115
body556370001054794142181
contents752370001053983130155196242268301
of1068370001054669
sodium1152370001053379127145190260
and1428370001053985132
chloride1576370001053884102148174192239281
were18733700010562104129170
26%2058370001054383146
and2219370001054086133
30%2367370001054284149
below2531370001054891109155217
normal,27643700010546921184253840010572111129144
corresponding585384001053984110136178210258306353400418465513
to1113384001052773
deficits1202384001054790113132171189216249
of1467384001054770
4001553384001054286131
mmol.17003840010571142189208224
Restoration1939384001054587120148193219259286304350397
of2352384001054770
the2438384001052774116
acid-base257038400105407997145172221261293336
balance425398001054889107146193232273
and714398001054086134
the864398001052774117
kidney997398001053756104151193232
function,1245398001052370117156185204250297312
rather157339800105266693139182208
than1797398001052773113160
decreasing1972398001054891131156198237269287333381
plasma2369398001054867106139210249
glucose2634398001054866112151196229272
levels,42541200105186199141159190205
seemed646412001053275117188231279
to940412001052772
drive102741200105477291130171
the1214412001052773115
normalization1345412001054693118190229247264299340366384430476
of1837412001054669
plasma1921412001054867106138208247
sodium.2183412001053379127145190261276
Conclusions:2475412001054994141180197243274292338384416430
Hyponatremia425426001055595144192240280306333375447465505
in948426001051865
severe1031426001053376116158184226
diabetic1275426001054866106154198226244283
hyperglycemia1576426001054885135179205252270310349390462481520
can2114426001053980127
be2259426001054892
explained2369426001054382131150190208255298347
both2734426001054997124171
by425440001054887
dilution52744000105486684130158176222270
and813440001053986134
a9634400010540
sodium1019440001053279128146192263
deficit.1298440001054891114133172190217233
The1547440001054089132
medical16954400010571114163181220260279
treatment198944000105285395134160232275322348
should2353440001053379126173191239
consider2608440001053984131163181229271297
both425454001054896123169
factors.610454001052364103133178204237254
Key880454001054385124
words:10204540010563109135182214229
Dehydration,12654540010556100146184231257297323341388435450
diagnosis,1731454001054866105153200247279297328344
urine,209145400105467291137180194
physiopathology,2301454001054895133166183230279319345392439458505554593604
diabetes425468001054866106154198226267300
mellitus,7454680010572115134152170198245277293
physiology;1057468001054996134167185232252299348388403
normal1480468001054794121194233252
saline;175146800105337493111158201216
pharmacokinetics.1986468001054996136162235275315360398418465508535554593627644
The4254920015377152211
physicochemical6594920015369142203257298356422481554613716758816880922
theory16034920015351125184250310375
of20014920015364112
gas21364920015362125179
bubble23384920015369141210279319378
formation-triggered4255060015348112172277341392432497571607657718760823888946100610671138
microcirculatory158650600153102144202263329388429491550623664728779845905971
dysfunction4255200015369131185235308383440494534599673
in11205200015339114
the12575200015351125184
critically14645200015356117159210250309373414456517
ill2004520001533880121
with21485200015392134185259
supporting4255340015351124193264330390445485561624
evidence10725340015359122164235294368425485
from15805340015348109176279
retrospective18815340015360121173234300354425486545598639701760
observational4255480015364133187248308374438489529594668732774
study12215480015352105177247308
Irena425569001242967121180234
Grad1,67956900124681071602208965700073329285690012426
Pia974569001245885139
Vovk11335690012463118170224
Racman1,13785690012459113158245299358172957000733246
2,178757000733318225690012426
Primož1868569001245896123210268316
Gradišek1,22045690012468107160220248292345401260357000733246
2,266157000733326965690012426
Maja4255820012485138167221
Šoštarič1,6665820012454112156193247286313359102358300733246
2,108158300733311165820012426
Juš11625820012441100144
Kšela1,13275820012461107160189243156358300733246
2,162158300733316565820012426
Petja17025820012458110148177231
Fister1,1953582001245279123160213252220358300733246
2,226158300733322965820012426
Matevž4255950012485138175229281330
Tomaževič1,7755950012455106193246294347400428473124759600733246
2,130559600733313395950012426
Radko13855950012460113173228285
Komadina2,16905950012462118205258318346405459214959600733250
32210596007333
1University4256150071304536140012165120143191240273313336369419
Medical8936140012181132189212257306329
Centre12436140012158107163195228277
Ljubljana,1542614001214770125182206230278333381402
Slovenia1965614001214973128175224280303351
2Faculty425628007130456627001214993138193216249299
of776627001215584
Medicine8816270012181132189212257280335385
University12886270012164119142191240273313336369419
of1728627001215584
Ljubljana,1833627001214771126183207230278333381403
Slovenia2257627001214972128175224279303351
3General4256410071304556400012165116172222255303327
and8036400012148104160
Teaching984640001215094142187242265320376
Hospital13816400012166121160217240274322346
Celje,17486400012158107131155205225
Slovenia1994640001214973128175224280303351
Background:565664001054485124161207233278325372420434
There1015664001054189132157199
is1230664001051850
growing1296664001054773118181200246294
evidence1606664001054382101148191238277318
of1940664001054770
microcirculatory2026664001057290129154200240258283321367386425451496523564
dysfunction260666400105488712014419123827742567800105274592139
being580678001054993111157205
a8016780010540
major8576780010572112130177203
factor1076678001052364103133178204
in1296678001051965
determining1377678001054891118159185257276322340387435
the1828678001052774117
extent1961678001054281111152199225
of2202678001054770
multiorgan22886780010572118137164182229255302341388
failure269267800105236482100146172214
and,425692001054086133148
so,58969200105327993
the697692001052774116
outcome829692001054693120157202273316
of1161692001054669
critically124669200105386482109127166206224242280
ill154269200105183654
patients.1611692001054889115133175221247280296
Quick19236920010558105123162198
acidification213769200105397896143161184203242282308326372419
of2571692001054770
a26566920010540
bicarbonate2711692001054967106146171425706001054997144184211252
anion695706001054087105152200
(HCO3-)-containing913706001052378129185225252273301342388436462502521568586633681
solution161270600105328099146173192239286
causes1916706001053980126159202235
carbon2169706001053979105154203250
dioxide2437706001054866113150169217260
(CO2)2715706001052372128168190
supersaturation-triggered425720001053379127171197231272299346371412439457504552580607633652700749792818860909
gas1352720001054888121
bubble1491720001054996145194213256
formation176672000105236996169209235254301348
in2133720001051865
that2217720001052774114141
solution.2376720001053381100146174192239287303
Blood2698720001054463110158207
is425734001051850
a4907340010540
HCO3--containing5467340010555104160199225254295340387412452470516534580628
solution118973400105338099144171189236283
as1487734001054072
well.15757340010562104123141156
Accordingly,1746734001055190127172198244262308356374413424
we21857340010563105
believe2306734001054891110127169209250
that2572734001052773113139
rapid2726734001052666114132180
occurrence425748001054787125172198224267314353395
of844748001054770
profound938748001054975121145191239286334
metabolic12967480010572115143183232280299317357
acidosis167774800105407998146193226244276
could1977748001053985132150199
result2199748001052668101148166193
in2416748001051966
gas2505748001054888121
bubble2650748001054896144193212256
formation42576200105236893164203229246292338
in779762001051863
the857762001052773115
critically98776200105396482108126164204221239277
ill.12797620010518365368
Gas1362762001055493124
bubbles1502762001054793140188207248280
form179776200105236894165
due1977762001054792134
to2126762001052771
CO222127620010549104143
supersaturation2370762001053277124167192224264290336360400426443489535
at425776001054067
first,51277600105234369102131146
then679776001052775118165
other865776001054773121164190
gases1076776001054787120163196
diffuse129377600105486690117164197240
into155477600105186591137
bubbles1712776001054896144193212256289
in2021776001051966
proportional2107776001054975121170219245275294341389428447
amounts.25757760010540112159206253280314330
Gas304762001055595128
bubble-blood319462001054996145194213256284334353401449498
interface-triggered37116200105186591133159185227266308336364390409457506549575617666
platelet439662001054968108134176195238265
adhesion468062001054089136179212230277325
and502462001054087135
activation517862001054080110128169209236254301349
with304776001056382110157
consequent322076001053985132164207256303346393419
capillary365576001053980128147165183223248291
occlusion396276001054687125143189221239286334
could431276001053984131150198
explain452676001054382130150189207254
microcirculatory479676001057290130156202242260286324370389429455501527569
dysfunction.538176001054887120304790001052371118158187206253301317
Methods:3386900010568112139186234283315330
With373890001057292119167
a3927900010540
retrospective39899000105266895122168201249293333363381422464
observational447590001054796129172198241282308327374422461480
study497790001053362109157196
including519690001051865105123170218236283332
all304710400105405977
admitted3142104001054089161179207237278327
patients3488104001054889116134177224251285
to3791104001052873
our3883104001054794120
ICU4021104001051970124
in4164104001051865
20204248104001054285125167
we44341040010563106
investigated4559104001051865104146179207226274314340382431
if5009104001051842
there5069104001052775118144186
exists5274104001054281100132161195
a54871040010540
correlation3047118001053985111138180199239265284331379
between3442118001054892120186228272319
the3778118001052774118
severity3912118001053376116158184203231272
of4201118001054770
metabolic42871180010573116143184232280300318357
acidosis466111800105407998146193226244276
in4953118001051965
patients5035118001054889116134177224251285
upon5336118001054795144191
their3047132001052774117135161
admission3224132001053987159177209241259305353
to3593132001052772
the3681132001052774117
ICU3814132001051868122
and3952132001054087135
their4103132001052774117135160
platelet4279132001054968107133175193236263
count4558132001053985131178204
trend477813200105275395142190
in4984132001051864
the5064132001052774117
following519713200105236988107153216235282330
two3047146001052793140
days.3209146001054887125159175
Base3406146001054485118161
excess3589146001054281120162195227
(BE)3838146001052368109133
from399314600105235096169
blood4183146001054968116164213
gas4417146001054888121
analysis4560146001053987126145184218235268
with4849146001056483110158
the5028146001052775118
lowest5168146001051866129172205233
pH54231460010548105
around3047160001054066112159206254
ICU3318160001051869123
admission3458160001053988160178210243261308355
was38291600010564105137
used3982160001054779123172
as4170160001054073
a42591600010540
marker43151600010572112138176218244
of4575160001054771
the4662160001052774118
severity4796160001053376116158184203230272
of5084160001054771
metabolic51711600010572116143183232280299317357
acidosis.304717400105408098146193226244276293
Platelet3361174001054462102128170189232259
count3641174001054085133180206
in3868174001051966
patients3955174001054889116134177224251285
upon4261174001054795144191
admission4473174001054089161179211244262309356
and4851174001054087135
lowest5007174001051966130172205234
platelet5262174001054968108134176195238265
count3047188001053883128174199
on3261188001054692
their3368188001052672114131156
second3539188001053274113157203250
day3804188001054785122
were39411880010562103128169
used4125188001054577118166
to4306188001052671
calculate439118800105397896134179197235261301
patient’s4707188001054787112130171217242260289
relative501118800105266684123148166204245
platelet5271188001054866105130170188230256
count3047202001053985132179205
decline3272202001054891131150168215258
after355020200105406394135161
ICU3731202001051869123
admission;3874202001054088160178210243261308356370
delta4263202001054891110138178
P44612020010544
=45242020010553
((P2−P0)/P0)459620200105234488130180226269291321366409432
x50472020010538
100.5104202001054382127142
Results:5265202001054588121167186213247262
Comparison3047216001055095167215255281300331378425
of3488216001054770
delta3574216001054890109136176
P37662160010544
in3826216001051865
all390721600105395876
six399821600105335189
groups4103216001054773118165213246
of4365216001054669
BE4450216001054485
showed4551216001053379126189231280
a48472160010539
statistically4902216001053361101127146177205224263303321339378
significant5296216001053350981441621852053047230001053979126152
difference321523000105486689116158184225272312353
(Kruskal–Wallis358423000105236693140172209250268313385423441459477509
test;4109230001052768101129145
p42702300010548
<43342300010552
0.001).4402230001054358101145184201214
Patients4632230001054483109127170217243277
from492523000105224995167
groups5108230001054873119166214247
with5371230001056381109156
more30472440010571117143184
negative3246244001054789137175201219258299
BE3561244001054384
values366024400105397996142184216
tend3891244001052767113161
to4067244001052771
have4153244001054786124165
more43332440010571117143184
negative4532244001054789137175201219258299
delta4847244001054789107134173
P.5035244001054449
Conclusions:5099244001054994140179197242273291336383414429
Patients3047258001054381107124166212237270
with3332258001056280106152
more34992580010570116142182
profound3696258001054873118140186231277324
metabolic40352580010570112138177224271289307345
acidosis439525800105397794141187218235266
upon4676258001054693140186
their4877258001052672114131156
ICU5048258001051867120
admission5183258001053986156173204235252298344
tend3047272001052769116164
to3230272001052773
have3321272001054787126168
larger350727200105195985132175201
relative372627200105266887127153172212254
platelet3999272001054868107134176194238265
count4282272001053985132179206
decline4506272001054891131150168215258
in4782272001051966
the4866272001052774118
following500227200105236989107154218237283332
days.5352272001054888126159175
Although304728600105517097143190237285331
in3394286001051864
a34742860010540
very3530286001053981107148
indirect3694286001051865113131156197237267
way,39762860010564104141152
these4144286001052774117149192
findings435228600105234288136154200248280
support4647286001053378126175222248278
our4941286001054793119
theory5076286001052773116163189231
of5323286001054670
gas5408286001054887119
bubble-blood3047300001054996144193213256284334353400448497
interface-triggered356830000105186591133159185227266308336364390409457505548574617666
platelet4257300001054868107134176195238265
consumption4545300001053985133165211283332359377424472
with5040300001056382110157
resulting5220300001052668101147166193212259307
microcirculatory3047314001057290130156202242261286325371390430456502528571
dysfunction3637314001054887120145193240280309328375422
in4079314001051865
most41633140010572120153181
severely4363314001053377116159185227246285
ill466731400105193755
ICU4742314001051869123
patients.4884314001054990116135178225251285302
REFERENCES30483370012357112167220281336407470524579
1.304735400853648
Tachon31093540083336193131169207
G,333035400834457
Harrois34013540083447798120157172198
A,361335400834155
Tanaka36823540083336199131161195
S,389035400833346
Kato39493540083356991128
H,409035400834457
Huet416135400834482117139
O,431435400834758
Pottecher43863540083357293118152184222257278
J,467835400832436
Vicaut47283540083365284117155177
E,491935400833346
Duranteau497935400834583104137175197231263300
J.529335400832436
Microcirculatory5343354008355701021231613047364008331466798136152184206242264298
alterations33593640083324770103125158179195233271297
in367036400831553
traumatic37373640083224376114171204226241273
hemorrhagic402436400833772130169190212251283322337369
shock.440736400832664102135165180
Crit4601364008340617699
Care47143640083407294128
Med.485636400835489129142
2014;42(6):1433-41.501236400833468100131143178210227261279291321352384417439476506515
doi:30473740083387692104
10.1097/CCM.0000000000000223.31663740083346678109141176209229268306361375410446482518555591627663699735771807844876911946958
2.304738400853652
Merdji311338400835490111149164179
H,330638400834457
Levy33773840083316598132
B,352238400833648
Jung358438400832462100139
C,373738400834053
Ince38033840083155385119
C,393638400834053
Siegemund40023840083334882122157215252290329
M,434538400835468
Meziani442738400835489119134166204219
F.466038400833239
Microcirculatory471338400835469101123160193208229260298313345367404425459
dysfunction51863840083387097117156194226250265303342
in304739400831553
cardiogenic31153940083316485123138176216251289304336
shock.346639400832664102135165180
Ann366139400834179117
Intensive37943940083145274108146172187219254
Care.40633940083407394128140
2023;13(1):38.421939400833468101135147177207225257271283318353366
doi:46003940083387792104
10.1186/s13613-023-01130-z.47203940083346578108136167203228252282312346377407428466499533555592624652682716740767781
3.304740400853651
den311140400833873111
Uil32354040083435873
CA,33214040083408296
Lagrand343040400833165104125158195234
WK,367740400835793108
van379840400833164102
der39134040083387394
Ent40204040083327091
M,412440400835468
Jewbali420540400832459110149182197212
LS,44304040083316578
Cheng452140400834077112150189
JM,47234040083247992
Spronk48284040083327193130168198
PE,50394040083356780
et513240400833456
al.52014040083324760
Impaired527440400831472111144159180214253
microcirculation304741400835771103124160192207228258295310342363378415453
predicts35134140083385992131146177201228
poor375441400833876114135
outcome39024140083367496126162220254
of416941400833655
patients42374140083387092106141178199226
with44764140083506587124
acute461341400833163100122155
myocardial478041400835787124156189209247262293308
infarction51004140083155271103124154178193230268
complicated5381414008330671243047424008338536798130151183221
by328042400833868
cardiogenic33604240083306282119134170209242279294324
shock.36964240083266299131160174
Eur38814240083326888
Heart398142400834377107128151
J.414442400832435
2010;31(24):3032-9.41914240083336697127140173203217250281298309343376408440459493503
doi:47064240083377489100
10.1093/eurheartj/ehq324.48184240083336375105135169201224255291311349383413434457472497528565602635667697709
4.304743400853651
Damiani311143400834577135150182220234
E,335843400833346
Carsetti34174340083397293120155177201217
A,364643400834155
Casarotta37144340083407399132153190212236269
E,399643400833245
Domizi405443400834584142157185201
R,426843400833549
Scorcella433043400833264101123153187202217249
C,459243400834053
Donati465843400834583122154175191
A,486143400834155
et492943400833456
al.49984340083324760
Microcirculation507143400835469101122159192207228259296311343365380418456
guided30474440083387691130165204
resuscitation32694440083215581119145177192215248269285323361
in364844400831452
sepsis:371844400832661100127142168181
the39164440083226095
next402944400833872104128
frontier?41754440083184178116138153188209232
Front44244440083335290128150
Med459144400835590129
(Lausanne).47384440083195084121148181219257292309320
2023;10:1212321.507644400833468101136147177209222252282313343378410442451
doi:30474540083387692104
10.3389/fmed.2023.1212321.31664540083346678114147181215239258317352392405441475508542555586616647677712744776785
5.304746400853650
De311546400834581
Backer321346400833568101131165186
D,341646400834657
Orbegozo349046400834769108144183222250287
Cortes37944640083407799123157184
D,399546400834657
Donadello406946400834584122155194229244259297
K,438446400833549
Vincent44514640083355290122155194215
JL.46834640083255770
Pathophysiology47714640083356789127165205243274301316354369408447479
of526846400833756
microcirculatory5342464008357721041251623047474008331466798136152184206242264298
dysfunction33654740083387097117156194226250265303342
and372747400833169108
the38554740083226095
pathogenesis39704740083397293132170209244282317344359385
of437547400833757
septic445147400832762101123138170
shock.464147400832664102135165180
Virulence.48404740083365374112127162200232266278
2014;5(1):73-9.513847400833468100131143178196227242254287321343378389
doi:30474840083387692104
10.4161/viru.26482.31664840083346678113143174204226259274295334347383417453489523535
6.304749400853550
De310949400834479
Backer31994940083356798127160180
D,339149400834555
Donadello345849400834481119150188221236250287
K,375749400833448
Sakr38174940083326493114
Y,394349400833542
Ospina-Tascon399749400834672110125161192214243270296327363400
G,440949400834255
Salgado44764940083326478116147185222
D,471049400834454
Scolletta47764940083326399114128162183207238
S,502649400833244
et508249400833354
al.51484940083314658
Microcirculatory5218494008353689911915518720122125128830475040083154668104126159
alterations32195040083314668102122155176191229267293
in352450400831552
patients35895040083387092107141179200227
with38295040083506587125
severe39665040083266193126147181
sepsis:415950400832661100126140166178
impact435050400831471110142174198
of456050400833756
time46295040083213693128
of476950400833756
assessment48385040083315884118145171228262300321
and517250400833169107
relationship5292504008320546910112213717521330475140083266479118
with31805140083506688126
outcome.33215140083377598128165224259271
Crit3606514008340617799
Care37205140083407394128
Med.386251400835590129142
2013;41(3):791-9.401951400833468100130141176206221255272284317351383402436447
doi:44815140083387692104
10.1097/CCM.0b013e3182742e8b.45995140083346678109141176209229268306361375410450486518548583617648679712745776808841876916928
7.304752400853645
Scardina31125240083336598119157172210243
P,337552400833540
Edwards343552400833371122155176215241
MA.369652400835597111
Prediction38285240083355690129144176201216254292
and414152400833270109
measurement427052400835893125151188210244302337375396
of468752400833756
bubble476452400833977116156172206
formation49915240083185677136168190205243282
in529352400831553
water536652400835184106139161
treatment.30475340083224377109131189224262284297
Journal335953400832463101122161193208
of358353400833756
Environmental365453400833371102118139176215273308346367400415
Engineering.408553400833270109124162197233254269307346359
2001;127(11):968-73.446053400833468104136144174204237253285313327339374410445468499533546
8.304754400853754
Levi313054400833268103120
M,327854400835671
Opal337854400834890125142
SM.354854400833491106
Coagulation368354400834180115156196213247270287327367
abnormalities407954400833374115155178239274291307331348384413
in452154400831555
critically4604544008332557296113147182199215249
ill48815440083153249
patients.49585440083407598115152192215245259
Crit52465440083416481105
Care.53795440083417699135149
2006;10(4):222.304755400833468104140152183214234266284296331366400413
doi:34755540083387792104
10.1186/cc4975.35945540083356679109137168203228257288321354387419431
9.304756400853649
Pontier311456400833572110132147182203
JM,33355640083247992
Blatteau34455640083365184105130163195233
JE,36965640083245770
Vallée3784564008336678297132168
N.396956400834559
Blood40455640083365190128168
platelet42315640083385486108142158192215
count446456400833168106144165
and464756400833270109
severity47745640083266193128149164187221
of501256400833857
decompression508756400833873105142201240261295322349364402440
sickness30475740083264173103142177204231
in329357400831553
rats33615740083215375103
after34795740083325176110131
a3625574008332
provocative36725740083396198130167200233255270303337
dive.40245740083385386120132
Aviat41725740083417187119141
Space432857400833371104136170
Environ451457400833270101117138175214
Med.474357400835590129142
2008;79(8):761-4.490157400833468104139152185218237271289301334366396415451464
doi:53805740083387792104
10.3357/asem.2299.2008.30475840085367186313558400833568102136157188215251310323360396430467478515550586623637
10.37935840083346679
Pontier389358400833674113135151186208
JM,41225840083258194
Jimenez42375840083254199135174210240
C,449858400834154
Blatteau45735840083365285107132167199238
JE.48325840083245872
Blood49255840083365291130171
platelet51175840083395688111145161197220
count535858400833269108147169
and304759400833372113
bubble318159400834080120161178214
formation34175940083195880141174197213253293
after37315940083335379114136
a3889594008332
dive39435940083395589125
to408959400832261
30417159400833571
msw426459400835986140
for44265940083185780
30452859400833571
min.462059400835975114128
Aviat47705940083427490124146
Space493859400833374108141176
Environ513659400833473105122144183223
Med.538059400835693134147
2008;79(12):1096-9.304760400833468104140152185218237269299317329359390425461484519530
doi:35926040083387792104
10.3357/asem.2352.2008.37116040083356679114147180213233264290325383397433467500533546582616652688701
11.30476140085366678
Pontier314461400833572110132147182203
JM,33666140083247992
Vallée3477614008336678297132168
N,366361400834558
Bourdon374061400833574112133171209248
L.400661400833245
Bubble-induced407061400833573112152168203226242280319356389422462
platelet45516140083385486108142157192215
aggregation478461400833271110131165205237259274312351
in515461400831452
a5225614008332
rat52756140083215476
model536961400835896136304762400833551
of311962400833857
decompression319862400833874108145205245267302329357372411450
sickness.36696240083274275106146182209237251
J3941624008324
Appl398762400834181122138
Physiol.414662400833674106134149188204217
2009;107:1825-9.438562400833469106142155186219252262293325359395417453465
doi:10.1152/japplphysiol.91644.2008.487162400833878931061371691822132422723063343503834234644805205595916196343047634008337536699132163199236249285319355390404
Patient-specific30476600015371133184225285358409446499570630689729781824882
in39526600015338113
silico4088660001535192134176234299
lung44106600015339110185248
modelling:468166000153102166238298337378420495559591
simulating3047674001535192197269310374425465540604
the36746740015351125184
effect38816740015358107157215274328
of42326740015363112
a43676740015362
severe44516740015352113176236296357
lung48316740015338110184248
injury51026740015338113158229291356
on30476880015364137
alveolar32076880015362104166225291330394456
recruitment36866880015359120179240315356407510569642693
Ruby30477090012459118179230
Dunphy1,32977090012470129189249308359365571000733236877090012426
Sjeng3733709001245482136195254
Quicken1,40087090012471131159205260312371437371000733244047090012426
Jur44507090012441100139
van46097090012453106165
Kimmenade1,4795709001246190176263316376429489543533271000733253647090012426
Julianna30477220012441100128156209269328381
Mangold2,34487220012485139198257315343404385172300733238867220012426
Mehdi39327220012485139198259287
Shekarnabi2,42397220012454113166222275314373426486514475272300733250
3,481372300733348477220012426
Vicente3047735001246492137190250287340
Estopier3407735001245398135193254282335374
Castillo2,38017350012460113157194223251278337413773600733241717350012426
Maciej42177350012485139184212266295
Orkisz3,45327350012472111165194238286482073600733248537350012426
Ashley30477480012466110170198251303
De33707480012469123
Bie3513748001246189142
Dekker4,36757480012470123179234287326400074900733240347480012426
Igor4080748001242988146185
Paulussen4,42857480012458110169197256300344397457474374900733247777480012426
Jean-Christophe3047761001244194148207241304362401428472509567628687741
Richard3,3808761001245987133193246284345415276200733249
5,421276200733342467610012426
Wouter42927610012489145204241294333
Huberts1,46467610012468128188242281320364500676200733250387610012426
Sam30477740012454108194
Bayat2,32617740012461114165218255351777500733250
63578775007333