860
ABSTRAKTY3363200011158114164221282345406464520
Z3909200011151
KONGRESU3986200011156116178239299356406466
/4478200011132
CONGRESS4536200011154116177239299355406456
ABSTRACTS5018200011158114164221282345401459509
(LIVES)2480320097236080125166206229
Physiology27263200974287124156175220240284330369
is31123200971951
the31803200972671112
only33093200974489109147
polar34733200974691111150177
star3667320097315999126
we38103200975899
have39263200974483121161
–410432009740
unikátní41613200974489108146186213258277
akce44553200973977112152
proběhla46243200974673117163205250269308
již4949320097203974
potřetí50403200974591118144185212231
v528832009739
Praze53443200974268108143184
|5584190011126
117565419001113676116
/23748040010732
Anest24518040010752100145178207
intenziv267880400107196794136184221240282
Med.29798040010770115165181
2026;37(2):116-1253179804001074487129171186230271291334356370407442481511549587631
/38558040010731
ANESTEZIOLOGIE39528040010753112155200245290342362424467527586607650
A46248040010752
INTENZIVNÍ4698804001071978123168226276296345405426
MEDICÍNA51458040010770114174195248268327381
www.aimjournal.cz4258040010765133201214257275349367415463490539579598614654693
current42562001053986112139182229255
practice70662001054976117157186205245287
of101862001054771
emergency1115620010543115159185232276323363405
medicine.1546620010572116165183223241288332347
Recommendations191862001054589129175248320364411460500527545593640673
for26176200105237096
education,27396200105439213942576001053980106125172220235
training6777600105275494113160178225273
experience96776001054382131175201220263310350391
and137576001054087136
quality152876001054894134153171199240
improvement178676001051890138165211250293365408455482
in228576001051865
the236776001052775118
emergency2502760010543115158184232275322362403
setting42590001053375102131150196244
are68490001054065107
well806900010563105124142
described96390001054890123162188206254297346
in132490001051965
the140590001052673116
literature.15379000105183663104129169196242267309323
POCUS1876900010543102153206245
can213790001053979125
reliably22789000105256785103142190209247
be254190001054892
used264890001054778121169
to283390001052772
identify425104001051867110157183202225268
reversible711104001052668108150176210227276295338
causes1067104001054080127159202235
of1320104001054771
CA14091040010550103
[1].15301040010625678816161040010515
However,16491040010556103167209249291317329
POCUS19961040010544103155209248
use2262104001054779123
during2403104001054794120139186234
cardiac2655104001053980106153171211250
arrest42511800105406692135168196
management6401180010572112159199248291363406453480
may11391180010572112150
be1308118001054993
associated1420118001054072105153193211251277319368
with1807118001056483110157
prolonged1984118001054875121140187235283326375
CPR2379118001055093137
pauses2535118001054989136168211244
[2].27991180010625709328901180010515
TEE425132001054183124
could573132001053985132150199
be796132001054892
used913132001054679122171
to1108132001052773
diagnose1205132001054867106154201249282325
reversible1554132001052668108150176210228276296339
causes1917132001053980126159202235
of2176132001054771
collapse,2271132001053985104122162210243287301
optimize2596132001054796123141213232267310
the425146001052774118
quality560146001054895135153171199241
of818146001054771
chest906146001054087130163191
compressions,1115146001053985157206232274308340358405453485501
guide1633146001054895113161205
therapies,1855146001052775118144185233252295328344
and2216146001054087136
identify2369146001051967110157184202226268
cardiac2655146001053980106153171211250
activity425160001054079109127167186214255
[3].696160001062570927871600010515
Despite8181600010557101134182200228269
potential1103160001054997123165212238256295314
advantages1433160001054088128169216242282330373406
during1855160001054894120139185233
resuscitation,2105160001052567100146178218236263303330348395442458
TEE2579160001054183123
is2718160001051850
not2784160001054795121
currently425174001053986112139181228254273312
widely758174001056382130174192232
adopted1010174001054089136185212254303
in1334174001051865
the1420174001052774117
routine1558174001052672119147166212256
practice1834174001054975116156186204244285
of2140174001054770
ED.2231174001054197111
As2362174001055286
described2469174001054891124164190209257301350
in2840174001051865
the425188001052774118
«5621880010535
2025617188001054285125168
European805188001054186112158207251290337
Resuscitation1162188001054588121167199239257285325352370418465
Council1647188001055096143190230248266
Guidelines19331880010555102120169212231249296339372
»,2325188001053446
further239118800105237197127175218244
studies2654188001053362109157175218251
are425202001054066108
needed557202001054791134183227276
to857202001052773
better954202001054993120150192218
define1196202001054891114134180224
the1444202001052774118
diagnostic1586202001054866106154201249281310328368
value197820200105408199146189
of2191202001054770
TEE2286202001054183123
in2434202001051865
identifying2523202001051867110157183202225268287334382
reversible425216001052566105146170203220267285327
pathology767216001054787112158204222268315354
and1135216001054085132
myocardial12822160010571107152191230255301318357374
contractility1671216001053983129154179219257286303321338364405
in2090216001051864
cardiac2169216001053877102148165203242
arrest242621600105396489130162189
patients2630216001054787112130171217242275
[4].425230001062567905132300010515
Development544230001055699138179198244292363406452478
of1037230001054669
a11222300010539
comprehensive1177230001053883154202228269315358404436453492534
guide1726230001054893111158200
is1942230001051849
also200723000105395788135
essential2157230001054375107149195221239278296
to2468230001052772
define2555230001054890112131177220
the2790230001052773116
minimum425244001057290137155227274346
training79224400105275394112159178224273
requirement1086244001052668117164182208250322365412439
for154624400105236996
an1663244001054087
effective177124400105436693136176206224264307
implementation2099244001051890139158201273316364390430457476523570
of2690244001054771
TEE2782244001054183123
into42525800105186592137
emergency5852580010543115158184231275322361403
medicine10112580010572115164182222240287330
practice.1364258001054975116156185204243285300
In1686258001051966
the1775258001052774117
meantime,19152580010572116155202228247319362376
developing2314258001054891131173192240289307354403
local2740258001051865106146165
CPR425272001055094137
protocols583272001054875121148193234279299331
in934272001051966
collaboration1020272001053985104123162211259285326353371418466
with1507272001056382110157
TEE-proficient1684272001054184124150200226272296315355373416463489
specialists2194272001053381125165184223242260292320354
may25692720010572112150
offer274027200105467097139165
crucial425286001053965112151169209227
information66828600105186588134160232272298317363411
to1095286001052772
physicians1183286001054896133166184223241280327359
involved1558286001051965103150169208251299
in1873286001051965
cardiac1954286001053980105152170209249
arrest221928600105406592133166194
management24292860010572112158198246289360404450476
(Figure42530000105236482130176202244
2).68930000105436578
Conclusion:787300001055096143183202248280298345393407
Focused1214300001054187128174207250299
cardiac1533300001053980106153171211250
ultrasound180330000105476693119160193240287334383
during2206300001054794120139186234
resuscitation2460300001052668101147179219237265306332351398445
represents425314001052668117144186220263311337372
an823314001054087
increasingly936314001051866106132174214247265312361379419
important1381314001051890139188214245286333360
skill176731400105337090108127
for192031400105237096
the2042314001052875119
modern21873140010572120169213239287
critical250031400105396685112131171212231
care2756314001054081107149
physician.425328001054998136170189229248288336352
Understanding8033280010556104153197223258287328376425444492541
cellular1370328001054082102121168187227254
physiology1650328001054998136170189237256305354395
and2071328001054189138
its223532800105194782
integration234332800105196693136186212254281300348396
into276632800105186693139
the425342001052774117
management5573420010572112158197245288359402449475
of1048342001054669
cardiac1133342001053979105151169208248
arrest139734200105396591133165193
may16063420010572111149
facilitate1771342001052363103121139156183224250291
decision-making2078342001054790130148179197244291318390430467486532580
during2674342001054894119138184232
resuscitation.42535600105266799144175214232258298324341387434449
Our8893560010558105130
experience1034356001054280128171196214256302341382
demonstrates1431356001054789160206253284312337377403443476
that1922356001052773112137
point-of-care2075356001054895113158184207255278302343382407449
TEE2539356001054081121
can2675356001053978124
be2815356001054790
instrumental42537000105186598126152200272315362389429448
in893370001051966
the979370001052875118
diagnosis1118370001054866106154201248281299331
and1470370001054087135
treatment162637000105275396135161234277324351
guidance1997370001054895113161201248288330
of2347370001054771
cardiac2438370001054080106153172211251
arrest270937000105406693135168197
and425384001054087135
acute580384001054080126154196
aortic795384001054088114144163202
syndrome.1017384001053373121169195241314357372
Further1408384001054186112142189233259
studies1686384001053361108157175218251
are1957384001054065108
required2084384001052668117164182208250299
to2402384001052873
validate249538400105408099117165205232273
the2788384001052774118
clinical42539800105395876123141180221240
benefit684398001054993140183206226253
and957398001053987135
feasibility1111398001052366105138156204223241259287329
of1459398001054770
implementing1549398001051890138158201273316363390408455503
TEE2072398001054183123
during2215398001054894120139186234
CPR.2468398001055194138155
Sodium4254220015366133204246318422
bicarbonate8694220015370109168231294363429502567618678
for15704220015348112172
hospitalized17644220015373137191262302353417459500558619690
patients4254360015370133184224284358409462
with9104360015392134185259
metabolic119243600153102161214278347413452494552
acidosis:17674360015362119160231295349390444478
a4254500015362
systematic5104500015351114168221282384449500540598
review11314500015359120184226286379
and15334500015362138208
meta-analysis176445000153102161214278315377452516558619673714769
of4254640015364112
randomized5604640015359123198269333436477535596668
controlled12504640015357122196247307374413454513585
trials18574640015351112154219261314
Muralie4254850012485144182235263291344
Vignarajah1,789485001246492151210264302355384437497128048600733213114850012426
Jason1357485001244194138197256
Vaillancourt1,16334850012464114142170198251310356414473511550218148600733222124850012426
Tessa22584850012455102146190244
Anzai2,25224850012465124172226254277548600733228094850012426
Garrett4254980012468122161199252290328
McDougall2,7744980012484130201259318378431459487126049900733212954980012426
Spencer13414980012454114168228273326365
Fansollato1,17264980012453103162206264293320374411469218849900733222194980012426
Zuhal4255110012458115175228256
Mohmand1,7015110012485143203289342402462116051200733211915110012426
Akira12375110012466120149188240
Kuriyama3,14985110012461118156184237290377430192851200733219615110012426
Gloria425524001246897155194221275
Vasquez-Grande4,7205240012464114158218277330378410481520573632692746146752500733215015240012426
Bram1547524001246199152238
Rochwerg3,18065240012459117163222298350389448225452500733249
5,231452500733349
62374525007333
1Department4255440071304535430012167118175223256292375425481513
of988543001215584
Medicine,10935430012180131188212256279334385405
Queen’s15195430012169124175226281302337
University,18785430012164119142191240273313336369419435
Kingston,2334543001215479134190229263317373394
Ontario,4685560012169125157206239262317337
Canada8265560012158107162210267315
2Department4255700071304565690012167118175223256292375426481514
of991569001215584
Emergency10965690012149132182215271321377422472
Medicine,15895690012180131188211256279334385405
McMaster20155690012180125206255294328377410
University,24465690012165120143191240273313336369419435
Hamilton,4685820012165114197220243276330386407
Ontario,8965820012169125157206239262317337
Canada12545820012158107162210267315
3Population4255960071304565950012153106163219242290323346401457
Health9345950012165116164187220275
Research12315950012153104143194242274319374
Institute,1626595001212479118152175208263296345365
McMaster20135950012180125206254293327377409
University24445950012164119142191240273313336369419
and4686080012148103160
Hamilton6496080012166114197220244277331386
Health10576080012165116164187220275
Sciences,1353608001215095118168224269318357378
Hamilton,17526080012166114197221244277331387407
Ontario,21816080012168125157206238262317336
Canada25396080012158106161209266314
4Department4256220071304566210012167118175223256292375425481513
of991621001215584
Medicine,10966210012180131188212256279334385405
University15226210012165120143191240273313336369419
of1962621001215584
Manitoba,20686210012180129184207240294351400421
Winnipeg,4686340012185109164219242299350407427
Manitoba,9176340012180129184207240294351400421
Canada13596340012158107162210267315
5Department4256480071304556470012167118175223256292375425481513
of990647001215584
Medicine,10956470012180131188212256279334385405
McMaster15216470012180126206255294328377410
University,19526470012165120143191240273313336369419435
Hamilton,24096470012165113196220243276330386406
ON,4686600012169135156
Canada6466600012158106161209266314
6Knowledge4256740071304566730012154111166239263313370427477
Centre,9546730012158107163195228277297
Hamilton12726730012166114197221244277331387
Health16806730012165116164187220275
Sciences,1977673001214994117167223268317356378
Hamilton,23766730012165113197220243276330386406
ON,4686860012169135156
Canada6466860012158106161209266314
Introduction:56572000105196692119165215261301331350397445460
Intravenous105172000105186692118159199241289336384416
bicarbonate1493720001054968108149175224272320361387429
is1948720001051951
a20257200010540
commonly2091720001053985158230278326345384
used2501720001054780123172
agent2699720001054089132180206
in425734001051865
the516734001052875118
management6607340010572112160200248292364407455481
of1167734001054770
acute1263734001054080127155197
metabolic14857340010573116144184233281301319358
acidosis.186973400105408098147194227245277294
However,21897340010555103166209249291318329
it’s25447340010518466595
clinical266573400105395876123142181222241
benefit425748001054993140183206226253
and695748001054087135
safety84774800105337497139167208
is1072748001051850
largely113974800105195884131175193233
uncertain.1388748001054794134175201232272290337353
We17587480010572113
summarized1887748001053379151223263289308344386435
the2339748001052774117
existing2473748001054382100132161179226275
randomized2764748001052667114425762001054895167186221263312
controlled754762001053984132158184230250268311360
data1130762001054888114155
and1301762001054087135
examined1452762001054382122194212259302351
whether18207620010563111154181228271297
the2134762001052774117
use2268762001054679122
of2406762001054770
intravenous249376200105186591117158197239286334381413
bicarbonate,425776001054867105145171219267314353379420434
as875776001053971
compared962776001053984156204244269311359
to1337776001052772
control1424776001053984131157183228247
or1687776001054672
an1775776001054086
alternate187777600105395784125151198237264305
type2197776001052768117161
of2373776001054770
fluid245977600105224490108155
without2630776001056381108155202248275
bicarbonate,304762001054967107148173222271318358385426441
leads350962001051962101150182
to371362001052772
improvements380762001051890139165211251293365408456482516
in434562001051865
patient-important443162001054990116135178225251275295366415463490520560608634
outcomes508662001054794122160206278321354
in546262001051865
those304776001052774120153195
hospitalized325876001054793126173192219259277295330371420
with369376001056382109155
acute386476001054079125152193
metabolic4073760010571114141181229276295313352
acidosis.44407600105407997144191223241272288
Methods:4744760010568111137184231279311326
We5085760010572112
searched521376001053275114139177223266314
Ovid3047900010559100119167
MEDLINE,3230900010568109165205223279320335
Embase,3581900010541112161201234277291
the388890001052774117
Cochrane402190001055096136182208249295338
library,43759000105193785111152178219231
and462290001054086134
Clinicaltrials.gov,47739000105506886132150190230248275302320360378410426474521560571
from53609000105235096168
inception3047104001051865105147195222241288335
until3401104001054794120139157
Jan3577104001053170117
2nd3713104001054389137
20263869104001054385126167
and4055104001054087136
included4210104001051865105123170218261310
randomized4539104001052667114162209282300336378427
controlled4985104001053985133159185231251269312361
trials536510400105275372112130162
of3047118001054669
hospitalized3132118001054794126173192219259277294330371419
adult3567118001054087133151178
participants3761118001054888113143161200218265305352378411
who41881180010563110156
received4360118001052667107148166205247295
intravenous467111800105186490116156194236283329376407
bicarbonate,5094118001054867105145171219267313353379420434
as3047132001054072
compared3134132001053984156204244269311359
to3509132001052772
control3597132001053883130156182228246
or3859132001054772
an3947132001054086
alternate404913200105395885126151198238264305
type4369132001052769117161
of4545132001054770
fluid463113200105234490108155
without4802132001056381108155202248276
bicarbonate,5093132001054867106146171220267314353379420434
for304714600105236995
metabolic31581460010571114141181229277296314353
acidosis.352614600105407997145192224242273289
We38311460010572112
excluded3959146001054381119137183231274322
studies4297146001053361107155173215248
examining4561146001054281121192210256274320368
oral4945146001054673113131
bicarbonate.5092146001054867106146171220268315354380421436
We30471600010572113
pooled3184160001054896144164207256
data3463160001054888114155
using364116000105477997144192
a38571600010540
random-effects3920160001052667114162210282310355378405448488518552
model44951600010572120169212231
and4749160001054087136
present4908160001054975117150194241267
risk519916000105264477113
ratios533616000105266793112159192
(RRs)3047174001052366110143163
or3225174001054671
mean33111740010571113151197
differences352317400105476587113155180221266305345377
(MDs),3915174001052389144176196209
along4139174001053957103149196
with4350174001056381108154
95%4519174001054283144
confidence4678174001053983129152170217259305343384
intervals507717400105186389129154196236254284
(CIs).537617400105237188119139151
We30471880010572113
assessed3183188001053972105148181214257306
individual3512188001051865113132172191239286325344
study3879188001053261108156196
risk409718800105264577114
of4233188001054771
bias4326188001054968107140
using448818800105477997144192
the4703188001052774118
modified48431880010572120169187211230273322
Cochrane5187188001055096137184209250297341
tool,3047202001052773121140155
and3219202001054087135
certainty3372202001053980106137177195242269310
of3700202001054670
evidence3787202001054383102150193240280321
using412520200105477997144193
the4335202001052774118
Grading4470202001055481122170188235284
of4771202001054770
Recommendations4858202001054588128174247319362409457497524542590637670
Assessment,3047216001055186119162195228299343390416432
Development35042160010557100140182201249298370414461487
and4016216001054087135
Evaluation4176216001054180121139186225252271318365
(GRADE)4566216001052376121174231272297
approach.4887216001054089138164210251291338354
Results:5265216001054588121167186213247262
Of3047230001055984
10663148230001054381126170
citations,333423000105405886126153171218266298314
we36652300010563106
included3787230001051966105124170219262311
941152300010543
RCTs4174230001054595140166
(n4357230001052368
=44422300010552
13314511230001054380120158
patients),4686230001054989116135177225251285306319
three5022230001052774100142186
of5225230001054770
which53122300010563111129169216
focused3047244001052370110157189232281
on3350244001054795
patients3466244001054990116135178225251285
exclusively3773244001054382120139185218235276318337376
with4171244001056382110157
severe4350244001053376116158184226
diabetic4598244001054866106154198225244283
ketoacidosis,4903244001053780107153193233251300347380398430445
with5370244001056482110157
initial304725800105186684112130170189
pH32612580010549106
values3392258001054081100147190223
ranging3641258001052667114163181228277
from394425800105235097169
7.00413925800105435094139
-7.06.430425800105266572115160176
Pooled4506258001054490138157200250
analysis4782258001054087127146185219237269
showed5077258001053380127191234283
that5386258001052775115142
bicarbonate3047272001054967107148173222271318358385426
may34942720010572112150
be3664272001054993
associated3778272001054072105152193211250277319368
with4166272001056483110157
decreased4344272001054891131157199239271315364
mortality47282720010572120146177217236254281323
(RR5072272001052367112
0.93,520527200105435899140154
95%5379272001054386148
CI:304728600105506883
0.82–1.05,3151286001054358103144186224235279321334
low3506286001051966130
certainty),3657286001053981107137177196243269311333346
and4024286001054087136
decreased4180286001054891132158200239272315364
need4565286001054791134184
for476928600105247097
renal4886286001052669116156174
replacement5081286001052668117136176216257329373420446
therapy3047300001052773115140179227264
(RR3326300001052366110
0.69,345130000105425699140151
95%3617300001054283145
CI3777300001054966
0.60385830000105425799142
to4015300001052771
0.80,4101300001054257100142156
low4272300001051965126
certainty)4414300001053878103133172190235261301322
compared4752300001053882153200240265306354
to5121300001052671
not5207300001054692118
using534030000105467794140187
bicarbonate.3047314001054967107148173222271318358385426441
Bicarbonate3506314001054463102143169218266314354380422
may39463140010572112150
have4114314001054787126168
no4300314001054895
effect441331400105436693136176206
on4637314001054694
length4749314001051962109157185232
of5000314001054670
hospital5088314001054795127176194222262281
stay5387314001053361102140
(MD3047328001052390147
of3215328001054670
0.413305328001054358101138
days3463328001054888126159
longer,3643328001051866113162205231242
95%3906328001054385148
CI4074328001055068
3.544163328001054257101145
fewer4328328001052366129172198
to4546328001052773
4.364639328001054358102145
days4804328001054888126159
longer,4984328001051865113161205231242
low5246328001051966130
certainty).5396328001053981107304734200105276785131157198220232
Conclusion:3295342001055095142181199245277294341388402
Bicarbonate3712342001054463101141167215263310349375416
may41443420010572111148
reduce4308342001052667116161201242
mortality45653420010572119145174214233250277318
and4899342001054086134
need5049342001054689132181
for524534200105236995
renal5356342001052667114153171
replacement3047356001052667114132171210250321363409434
therapy3496356001052773115141180227265
in3776356001051864
hospitalized3855356001054793125172190216256274291326367414
patients4285356001054787113131172218244277
with4577356001056381107153
metabolic47453560010571114140179227274292310348
acidosis,510835600105397896142189220238269284
but5407356001054894120
further304737000105236994123169211236
data3298370001054785111150
is3463370001051849
needed3527370001054688130178220267
to3809370001052771
increase3895370001051863102127167205237279
precision4189370001054773113152170201218263309
in4513370001051864
effect459237000105426490131170198
estimates4805370001054274101119189228253293325
and5145370001053985132
further529237000105226994123169211235
assess3047384001054072105148180213
the3276384001052774117
impact3409384001051990138179218248
of3673384001054670
bicarbonate3759384001054867106147172221269316356382424
on4199384001054694
other4309384001054773120163189
patient-important4514384001054889115134176223249273292364412460486516556603629
outcomes.5159384001054794121159204277320352369
Physiology30474080015371143204258299364403467531594
at36644080015362113
the38004080015351125184
edge:40064080015359130194252285
septic43134080015352113183236276335
shock46704080015352126190250324
in50174080015338113
BiVAD-supported30474220015371111192268354395448521590661727787842902974
patients.40434220015370134185225285358409463497
What456342200153110187251302
happens48884220015372136206276337410464
to53754220015351117
shock30474360015351126190249323
physiology33934360015370143204258299364403467530594
when40104360015392164223297
the43294360015351125184
heart45364360015372132195257313
is4871436001533993
no49874360015372137
longer51474360015338103176240297358
the30474500015351125184
pump?32544500015369142246315372
Lyuboslava3047471001245199158219277321350403455508
Vladimirova3575471001246492146206234320348387445497550
Pampulova1,41454710012458111197258317345403455508464747200733246784710012426
Stanislav3047484001245490144203231275303357408
Hristov34764840012469107135179216274326
Georgiev2382248400124691231822202793083614134235485007332
1Department304750400713030755030012167118175223256292375425481513
of3610503001215584
Anesthesiology37155030012161116167206240295346385408463487542599647
and43835030012148103160
Intensive4564503001212480112161217256279327376
Care,49615030012158107139189209
St.3090516001214981102
Ekaterina3213516001214996145177227259283338386
University36205160012165120143191241273314337370420
Hospital,40615160012165121160216240273322345366
Sofia,44485160012149105134160208229
Bulgaria46985160012154109133189237269293341
2Department304753000713030785290012167118175223256292375425481513
of3613529001215584
Cardiac37185290012158106139195218266311
Surgery,40505290012149104136192242275326342
St.4413529001214980102
Ekaterina4536529001214995145177226259283338386
University49435290012165120143191240273314336370419
Hospital,30905420012165121160216240273322345366
Sofia,34775420012149105134160208229
Bulgaria37275420012154109133189237270293341
Introduction:318756600105196692118164213260300329348395442457
Mechanical36615660010569112153200240287305344385404
circulatory408256600105395783122168187227253299325367
support4467566001053379127176224251281
devices4766566001054891131150189231264
have5047566001054787126168
become5233566001054893133179251294
an3047580001054087
integral316058000105186591133182208249267
component3453580001053985158206254302345393419
of3898580001054670
modern39945800010572119168211237285
cardiac4305580001053980106153171211251
intensive458158000105196692134181213231271314
care,4920580001054080106148163
significantly510858000105335199146164188207247287335361380419
improving3047594001051890139165211251270317365
survival3438594001053379105148167208248267
in3731594001051865
advanced3822594001054088128169216256298347
heart4194594001054891130156187
failure.440659400105236583101148174216231
Implantation4662594001051991139159198246272313339358405453
of5140594001054771
a52365940010540
biventricular5302594001054867108150197304760800105275372111157175214240
assist3303608001054072104122153181
device3500608001054891130149188229
(BiVAD)374560800105236785131178234255
profoundly4016608001054874120143189236283331349388
alters442060800105395885126152185
cardiovascular4621608001053979104151169216255295327367413431470496
physiology,5133608001054895133166183230249295344383394
creating3047622001053965107147173192239287
a33596220010540
state3424622001053261101128170
of3618622001054771
device-dependent3714622001054891131150189231259309352401445492541584631657
circulation439662200105395883122168187227253272319366
in4787622001051966
which48776220010564112130169216
pump5118622001054996168217
flow,535962200105234593156168
rather304763600105266692138181206
than3268636001052774113159
intrinsic344263600105196590116134180212230268
myocardial37266360010571108154193233258305323361379
performance,4121636001054891116142188214285325371410451464
determines4601636001054789116157182254272318360393
cardiac5009636001053979104150168207246
output.5270636001054793120168214241257
With3047650001057292119167
Frank–Starling3232650001054064105152189232270296336362381399446495
mechanism37456500010572115156203243290308340412
no4175650001054794
longer4288650001051865113161205231
functioning4537650001052371118158187206253300319366414
adequately,4969650001054089132181227267294335354393405
and5392650001054087136
the3047664001052774118
presence3188664001054975117150194241280322
of3533664001054771
concomitant3627664001053985133172218290309336377424450
autonomic4101664001054086114159207254327345385
and4509664001054087135
endothelial4668664001054290138185212259303322340379398
dysfunction,5089664001054888121145193240280310328375423438
the3047678001052774117
heart’s3181678001054790129155185204234
capacity3431678001053980128169208226254295
to3742678001052873
respond3831678001052668101149197244293
to4140678001052772
physiological4229678001054896133166184231250297346364404444463
stressors470867800105336187129162194242268301
is5026678001051850
substantially5092678001053379127160188228275301320359378396435
compromised.3047692001054087161210237284358377410455505521
In3595692001051866
this368869200105287695128
context,3842692001054087135162205245276292
the4161692001052776120
onset4307692001054897130174202
of4536692001054772
septic4634692001053378127155174215
shock4875692001053481130171209
may51116920010573114153
generate52906920010549931411862123047706001054067109
metabolic31817060010573116144184233281301319359
and3566706001054087135
hemodynamic3727706001054891163211260300348388460479518
demands4271706001054892164204251300332
that4629706001052775115142
exceed4796706001054382121163207256
the5078706001052775118
adaptive5222706001054089129177204223263306
capacity3047720001054081130172212231259302
of3375720001054772
device-supported3473720001054892133152193235264298345394444493520551593643
circulation.414272000105405985124172191231259277325374390
Methods:45597200010569113141189237287320335
We49217200010573115
analyzed5062720001054088129148188227269319
the5408720001052775119
pathophysiological3047734001054989116163211260307345379396443463510559577617657676
mechanisms37417340010572116156203243290308340412444
underlying4204734001054693142185211230269288335384
septic4606734001053376125152170210
shock4834734001053379127167204
in5056734001051966
BiVAD5140734001054463109156213
supported53717340010533791283047748001054997124154196245
patients,3318748001054990117135178226252287302
with3646748001056483111158
particular3830748001054990116146165205252270310336
focus4192748001052370111158190
on4408748001054795
hemodynamic4529748001054791163211260300348388460479518
responses5073748001052669102150199246279322356
to5455748001052773
pump3047762001054996168216
flow328176200105234592155
adjustments3454762001054088107153185214286329377403437
and3908762001054087136
on4061762001054794
laboratory4173762001051858107155181222249294321363
parameters4553762001054989115156228271299340366400
reflecting497076200105266892114157197227245292341
tissue532876200105274577110156199
perfusion,3047776001054994120147195228246294342357
inflammation,343077600105196690112152225298338365384432480495
and3952776001054088136
organ4115776001054774121162209
dysfunction.4350776001054989122147196243284314332380428444
In4821776001051866
order4913776001054774122165192
to5131776001052774
respond5231776001052668102151199248296