850
PŮVODNÍ425200011151111173233294355388
PRÁCE839200011151111174230285
/1150200011132
ORIGINAL1208200011158118151213244306367421
PAPER1654200011151107163217278
Comparison4253200974690158204243270289321366412
of8533200974468
ibuprofen9383200971965110156183227251292338
and12923200973984130
paracetamol14393200974585112151188228255295362407427
combination18833200973679147193212257296323342387432
with23323200975979106151
ketorolac24993200973878105149176221241280316
and28323200973984130
paracetamol29793200974585111151187227255294362406426
in34223200971964
patients35033200974585112131172217243277
undergoing37963200974590136176203249293313358403
gynecologic42163200974584130171208251271316362381418
surgery46513200973176102148189216256
24815620001114293143
|343200011126
ANESTEZIOLOGIE4268040010753112155200245290342362425467527586607650
A10988040010753
INTENZIVNÍ1172804001071978123168227276296345405426
MEDICÍNA16198040010770114174195248268328382
/20468040010732
Anest21238040010753101145179208
intenziv235080400107196794137185222241282
Med.26528040010770114164180
2025;36(4):247-2522852804001074487128172185229273296338359374418458499522560604646
/35438040010732
www.aimjournal.cz48358040010765133201214257275349367415463490539579598614654693
+425540012160
paracetamol506540012157106138187231280314363446501525
(1000105354001212874121174227
mg).1301540012183139166184
Po1507540012153106
6,163554001215172
241728540012151100
a1849540012148
481919540012151104
hodinách2044540012156111168191246294339394
po2460540012157112
operaci2594540012155112163196244289312
jsme292754001212564147197
hodnotili3146540012155110168223278311334357380
numerickou3548540012155110193243276300345391445500
škálu407054001213986135158213
bolesti4305540012156112136187226260283
(NRS),460954001212993148198225243
dobu4874540012156111169224
srážlivosti511954001214072121164188210259313352386409
(CT),42568001212884137168186
dobu633680012156111168224
krvácivosti87868001214781132180225248296350390423446
(BT)134668001212881131163
a1530680012148
IL-6.15996800121247194149170
Výsledky:425820012360110150176227285335388411
Skóre85482001214995148180229
bolesti1100820012156111135184223257279
a1396820012148
CT1461820012158109
se158882001213989
mezi1694820012182132175198
oběma1909820012154111161243290
skupinami221782001213985139195218273320402425
významně265982001214797142196244326380430
nelišily.3106820012155105128150189211234281297
Skupina342082001214994149205228282330
s3767820012139
ketorolakem382382001214795128181213267290338384432514
vykazovala435582001214797144192235289335383406453
významný482582001214898142197244326381425
nárůst5267820012155103135189228261
BT425960012154104
po546960012157113
2467696001215199
a793960012148
48859960012151103
hodinách980960012155110167190245293337392
(p139096001212884
<1492960012159
0,05),156996001215171122172199217
zatímco180496001214292124147230275328
skupina215096001213986141197220275323
s2491960012139
ibuprofenem254896001212379134191224278307357412462545
měla3111960012183133157204
po3333960012157112
24346396001215199
hodinách3580960012155110167190245292337392
významně398996001214898143198246328383433
nižší444096001215578121162184
hladiny464296001215679126183206261306
IL-649659600121247194148
(p513196001212885
<5234960012159
0,05).531196001215171122172198217
Závěr:4251100012357109158208244269
Oba7131100012169126175
režimy907110001213383126149232278
byly12041100012157103127175
co1397110001214599
do15151100012156111
zvládání1645110001214394118166222270326349
bolesti20131100012157112136187226260283
stejně2315110001213973123146202252
účinné.25861100012155100123178233284304
Ovšem29081100012169119158208292
kombinace32191100012147100184241264320368412461
ketorolak‑paracetamol3699110001214796129183216271295343390418476525557606651700733782865920944
významně4662110001214899144200248331386436
prodlužovala5117110001215790145202225280323377425124001214897120168
dobu6151240012156111169224
krvácivosti,861124001214781132180225248296350390423446467
zatímco1350124001214393125148231276330
kombinace17021240012147101184241265320368413462
ibuprofen‑paracetamol2186124001212380135192225279308359414447505553586634679728762810894949973
byla31811240012157103127175
účinnější33781240012155100123178233284307346370
při3769124001215790114
redukci3905124001213282139194241284307
zánětu4234124001214393148199232287
prostřednictvím4543124001215790144183217250299357412435480515566590673
snížení5238124001213994118161211266289
hladiny425138001215579127184207262307
IL-6.75413800121237193149170
Tyto945138001215091127181
rozdíly1147138001213387129186209234282
je1450138001212474
třeba1546138001213365115172221
brát1788138001215790138171
v19801380012148
úvahu,20491380012155104152208262283
zejména2353138001214393117200250306354
pak27281380012157106153
u29021380012155
pacientek29781380012157106151174224279312361408
s34071380012140
rizikem346813800121335799123169218302
krvácení.3791138001214781132181226275330353374
Klíčová425155001235885111155211261312
slova:758155001234268124174225248
léčba1027155001212474120176225
bolesti,12731550012157113137187226260283304
koagulační15981550012147101149205260283331376431454
profil,2074155001215789144173199223243
interleukin-6,2338155001212479111161193217267323369394449482537558
ibuprofen,2917155001212380135192225279309359414435
ketorolak,3373155001214796130184217271295343390413
paracetamol,38071550012157106139187232281314363446501526546
gynekologická43741550012156104160211258312336391447471515562611
operace.50061550012155112163196245290339359
Introduction4251980015340115166227293365436493547587653726
Gynecological425216001075695144188230276296344394413453494513
surgery958216001073380107155199225268
is1246216001071951
a13172160010740
common1377216001074086161234283331
procedure1728216001074976123164207257304331374
that2121216001072876117144
frequently228421600107245194144192236284311330370
results2673216001072770104151169197232
in425230001071967
postoperative515230001075099133162208259303330372399418459502
pain1041230001074991109157
of1222230001074872
varying1318230001074082108151171219268
intensity,161023000107196793136184217235263306318
ranging1951230001072769117166185233282
from225723000107235198172
moderate24532300010774122172216243284311354
to2831230001072874
severe425244001073478119162188231
[1].683244001092669907712440010716
Inadequate813244001071967108157201251299340367410
perioperative1249244001075095121141189239284310352379398439483
pain1758244001075091110158
management19422440010774115163204253297371415464491
can2459244001074081130
result2615244001072670103150169197
in2839244001071866
multiple4252580010773120139166185234253296
complications,737258001074086160209228246286327353372419467500516
including1269258001071866106124171220238285334
hemodynamic1619258001074892165213262302351391463482522
instability,215725800107186698127168217236254272300342353
prolonged2526258001074976122142189237286330379
recovery,425272001072771113160201245272316328
immunosuppression,780272001071994169217266315349397448499526570604638657706756772
and1579272001074190140
an1746272001074290
increased1863272001071968110137180221255300351
risk224127200107274780119
of2387272001074873
developing2487272001074994136180200249300319368418
chronic425286001073986112157205222261
pain702286001074989107153
[2].871286001092570929612860010715
Postoperative992286001074489122150195244287313353380398437479
pain1487286001074989107153
following165628600107236988106153216234281329
gynecological2000286001074888135178218264282329378396435475493
procedures2509286001074975120160202250296322364396
may4253000010776118158
arise61130000107426989123169
from808300001072453101178
various1014300001074184112132182231266
surgical1307300001073583111161180222265285
approaches,1620300001074293145173221265307356402437454
including2102300001071968110130179230250299351
laparotomy2480300001072062113156184232261309386426
and425314001074189138
laparoscopy586314001071959109151177224258298345395434
[3].10433140010926729511363140010716
Although1174314001075372100148196245294342
laparoscopy1539314001071959109150177224257298344395434
is1995314001071952
considered2070314001074086135168186235279306349399
a24913140010741
minimally2555314001077392140158232273291310350
invasive425328001071967106148181199240283
technique,733328001072870111159207226275322367381
postoperative1138328001075099133162208259303330372399417459502
pain1664328001075091110158
remains1846328001072770143184203251284
a21543280010741
significant2219328001073452101149168192212252293341368
concern2612328001074086135176218244293
that425342001072876117144
warrants5893420010765106132160201249276311
proper920342001074976123173218245
management.11843420010774115163204253297371415463490506
Postoperative565356001074592125154201251296322364391410451494
pain1078356001075092110158
involves1255356001071967106154174214258291
a15663560010740
combination1626356001074086161210229277318345364412461
of2106356001074872
nociceptive,2197356001074897138156197239289316335376419434
inflammatory,2650356001071967901131532274253700010774114142188215258270
and712370001074189139
neuropathic868370001074993140167214264306333381400440
components1325370001074187161211260309353401428463
resulting1805370001072770103150169197216264313
from213637000107235198172
tissue232637000107284779113160204
injury254737000107196786133159202
and2767370001074189138
inflammatory42538400107196790113153227300341368415442485
response926384001072770104153202251283328
to1270384001072875
surgical1362384001073380107155173214255274
trauma165338400107285496143217258
[4].19283840010926699320193840010716
Therefore,2051384001074292136163206229277304347361
a24293840010741
multimodal24873840010773121140168186260308358399418
analgesic425398001074190131150199244278296337
approach789398001074191141168216258299347
combining1156398001074188163213232280299347397
multiple15803980010774122141169188238258302
drugs1909398001074976125174208
with2143398001076685113162
different233239800107496892120164190234282309
mechanisms26683980010774119160209425412001074190109142216250
of702412001074872
action801412001074182113132181230
is1052412001071952
strongly113141200107336390138187237256297
recommended1455412001072670112159234308353402452497548
to2029412001072876
achieve2131412001074283132150195236280
optimal2438412001074899127146220261281
pain2746412001075092111159
control425426001074189139167194243263
while7154260010767117136156201
minimizing943426001077595144163238258295315365415
the1386426001072878123
adverse1537426001074192134179206242287
effects185142600107457098143185216252
associated2131426001074176110160202221263291335386
with2545426001076686115164
high2737426001074968119168
doses425440001074997131175209
of653440001074872
a7454400010741
single80644000107335199149167211
agent1037440001074190134183209
[2].12664400010926729513604400010716
Non-steroidal5654540010757106155183217245288315362381430470489
anti-inflammatory1074454001074189116135163183230254276317390464505532578605648
drugs1742454001074976124174206
(NSAIDs)1968454001072481122174193251285306
and2294454001074189138
paracetamol2452454001075091118159200242270312385434453
(acetaminophen)425468001072463105148177219294313362411462512557606628
are1080468001074269112
central1219468001074185134161189231251
components1497468001074088163214264314359408435471
in1995468001071968
multimodal20904680010775123142171190265315366407427
postoperative2544468001075010013516421226330933642548200107416989131175
analgesia.627482001074291132152202247282301342359
Ibuprofen1013482001071970119169197245270314364
is1404482001071952
a14834820010742
non-selective1552482001074998148177212257277322364395414456500
cyclooxygenase2080482001074084124144193243282326375420470511545590
(COX)2698482001072474133181207
inhibitor425496001071967116135185205233280308
that759496001072877118146
reduces932496001072770121169210253287
the1246496001072877121
production1394496001075078125176224265296315364413
of1834496001074872
prostaglandins1933496001075077125159188230280300341389439458507540
involved2500496001071967107155175217261311
in2838496001071967
pain425510001075091110158
and603510001074088138
inflammation.76151000107186690112153226300341368386434483499
Ketorolac1280510001074588116163190237256297337
is1637510001071952
a17085100010741
more17695100010774122149192
potent1981510001074999126168217243
NSAID2244510001075898150169227
with2491510001076584112160
strong267151000107336289136185234
analgesic425524001074189130149198242276294334
effects78052400107446895139180210245
and1046524001074189138
is1206524001071851
frequently127852400107245295144192236284311330370
administered1669524001074191164183231249282311353380423473
intravenously216352400107196794120162202245293342390423441482
for266652400107237198
the2785524001072876120
management4255380010772112158198246288360403449475
of915538001074770
severe1001538001073275115156182223
postoperative1240538001074896128156201250293319359385403443485
pain1740538001074989106153
[5].19085380010925689219995380010715
Paracetamol,2030538001074483108148188229255295367414433447
although249253800107405885132179225273320
its282753800107184579
mechanism4255520010773117157205245292310342415
of856552001074771
action943552001074080110129176224
is1183552001071951
not1250552001074895122
fully138855200107247290109148
understood,1552552001074795144187213247275321369419434
is2002552001071951
believed2069552001074993112130173213256305
to2390552001072874
act2480552001074181110
centrally2606552001074082130156182223242260299
to425566001072874
exert519566001074484126153184
analgesic723566001074088129148197241275293334
and1076566001074189139
antipyretic1234566001074189116135184224251294322341381
effects163556600107436795138179210244
[6].18995660010926709519925660010716
Despite5655800010758104138189209238281
their866580001072777122141168
effectiveness,105458000107446897141183214234276320369414449483500
NSAIDs1574580001075799151171230265
are1859580001074068112
associated1990580001074175109159201220262290333384
with2394580001076585114163
potential25765800010750100128172221249268310329
side425594001073352100144
effects,58759400107436794137178209243260
particularly864594001074990117148167207255274314340360400
affecting128259400107406391134175206225272321
the1621594001072775119
coagulation1758594001073986127176223243283310329377425
and2201594001074088137
gastrointestinal2355594001074989122151178225244292319361395424443491531550
systems.425608001073476110140184258292310
All76260800107537392
NSAIDs881608001075899152172231266
can1174608001074082131
inhibit1332608001071968117136187207236
platelet1595608001075070112140183203248277
aggregation1899608001074191142169213264305333353402451
to2378608001072775
varying2480608001074183110154175224274
degrees,2781608001074994425622001074976120166200217
with662622001076585114163
ketorolac845622001073882111158186234255296338
being1203622001074995115164214
associated1437622001074175109158200220261289333384
with1840622001076586114164
a20246220010740
higher2084622001074968118167212239
risk234362200107274781119
of2482622001074873
bleeding2575622001074970115160211231280330
due425636001074997142
to585636001072875
its67963600107194783
greater781636001074876119160188231259
potency10586360010750100128171220261304
[7].138163600109267310114816360010716
Postoperative1515636001074592127156204255300328370398418459503
coagulation2037636001074087130180228248289317337386435
disturbances2490636001074969102132181208259301350391425650001074480
may5336500010775117158
lead720650001071965107158
to907650001072876
serious1012650001073480108129178228263
hemorrhagic1304650001074994170221249278328371422442484
complications,1817650001074089165216237257299342371391441491526543
particularly2389650001075094121154174216266286328356377419
in2837650001071968
surgeries425664001073481109158203230250295330
with779664001076585114163
significant966664001073453103152172196217258301350377
bleeding1368664001074970115160211231280330
potential,17226640010750100128172221248268309329345
such2091664001073482123172
as2288664001074075
gynecological2387664001074990140185227275296345396415456499519
procedures.425678001075078125168211262310338381416434
Moreover,5656920010772122150194245286331358371
the963692001072979124
postoperative11156920010751101136166214266312340383411431473518
inflammatory166069200107206993117159234310352380429457501
response2189692001072771106157208258292338
mediated25486920010775121172192234262306357
by425706001075089
pro-inflammatory541706001074976124153173221244267308381455496523570597640
cytokines1208706001074082114160199219267312346
such1580706001073481121169
as1776706001074174
IL-6187670600107206078125
is2021706001071952
also209970600107416093141
of2267706001074872
concern.2365706001074087136177219246295311
IL-6270270600107196078125
is2854706001071851
released42572000107277089133173206250300
in745720001071967
response831720001072770103153202250283328
to1178720001072875
tissue127272000107284780113160204
injury149672000107186685132159202
and1717720001074189139
correlates1875720001074087114141184203244271313347
with2242720001076584112160
pain2422720001074991110158
intensity259972000107196794136184217236264306
and425734001074189138
the580734001072876120
overall717734001074788131157199218236
postoperative970734001075099132161208258302329370397416457500
stress148773400107346289132166199
response1703734001072669103152201249282327
[8,204673400109267089
9].215273400109466922207340010716
NSAIDs2252734001075898150169227261
are2529734001074168110
known2656734001073888136201250
to425748001072874
modulate5197480010774123173220239280307349
this88874800107287695128
inflammatory103674800107186690112153226300341368414441484
cascade.1540748001074082115156197247291306
Comparing1866748001075198172221263289308356406
the2292748001072876120
effects243274800107446795138179210245
of2697748001074771
different27887480010749689242576200107246794136185211
analgesic658762001074189130149198242276294335
combinations1014762001074187161211230278319346365413461494
on1530762001074897
IL-6164976200107195977124
levels1795762001071963104147166199
can2016762001074082130
provide2168762001074976123164183232276
insights2466762001071967100118167215242277
into276576200107196793140
their425776001072876120139165
capacity610776001074082131173213232260303
to932776001072875
attenuate102677600107416899141190237278305347
systemic1393776001073475109138180254272313
inflammation.172577600107196791113154227301341368387435484500
Given3187202001075675116158206
the3410202001072775119
importance3546202001071891140189216247288335376418
of3980202001074872
achieving4068202001074181129147191231250298347
effective443120200107446794138178208227268311
pain4758202001075091109157
control4931202001074087135162188235254
with5202202001076483111159
a53782020010740
favorable54352020010723653047216001074086112153201220263
safety332621600107337496139166207
profile,3549216001074975121144163181224238
this380221600107287593124
study3942216001073361108156195
aims4153216001074058130162
to4331216001072773
compare4419216001074085158206247272314
the4749216001072774117
efficacy488221600107436692111150191230272
and5169216001074087136
safety532021600107337497139166208
of3047230001074770
two3133230001072793140
commonly3288230001074085158230277324342381
used3685230001074779122171
analgesic3871230001074087127145193236269286325
combinations4212230001073985157206224271310337355401449481
ibuprofen-paracetamol4712230001071866113162188234257299346373423463489529569610637677749796815
and3047244001074189138
ketorolac-paracetamol3203244001073881109156183230249290331353404446472514554597625666739788808
in4030244001071967
patients4115244001075091118137181229256291
undergoing4424244001074896145189216264312331379428
gynecological4870244001074990139183224271290339389407448489508
surgery.53962440010733811073047258001074992118160172
The3235258001074191134
comparison3385258001074086159208249275294326373421
focuses3823258001072370110158190233267
on4106258001074795
postoperative4217258001074998131159205255299325366393411451494
pain4727258001074990109156
intensity,489925800107186692134181214232259301312
changes5227258001074088128175224267300
in3047272001071967
coagulation3133272001074187129178226245285312331379428
parameters3580272001075092118160233278305348374409
(CT,4008272001072474119129
BT),4157272001074588115129
and4305272001074189139
serum4463272001073478105153227
IL-6470927200107195978125
levels.4854272001071963103147166198215
Material30472960015398163214274335377441483
and35532960015362138208
Methods37842960015398159211285350421475
A30473140010754
double-blind,31283140010750100150201221267297349370389438489506
randomized3661314001072770120171221297316354398450
clinical413931400107416080129148190233253
trial441931400107295676118138
was45843140010767110144
conducted4756314001074189139190239281312356408
between5191314001075197126196241287336
December30473280010758102143185259308353379
20243442328001074487128168
and3626328001074189138
March37803280010770111137175223
20254020328001074386127171
at4207328001074168
Dr.429132800107588598
Wahidin44053280010774113161179228246294
Sudirohusodo4715328001074289138156182229277325357405455503
Hospital52353280010756104137186205233274293
and3047342001074189138
its320234200107184681
affiliated330034200107406491111129148188215257307
network3624342001074892120187235262300
hospitals.3941342001074896129179198226267286318335
The4292342001074292136
study4444342001073463111160200
design4661342001074992126144193241
was49193420010765106139
approved5075342001074090140167213254297347
by5438342001075089
the3047356001072876120
Ethics3184356001074268117135176210
Committee3411356001075298172246265293323366411
for383935600107237198
Biomedical3954356001074564112186230280299339381400
Research4371356001074589123167207234273321
(No:4709356001072481129144
1010/UN4.6.4.5.31/4870356001074484123163194251308352368412428472487532546591630657
PP36/2024).3047370001074589131175206250293335375396409
Eligible318738400107436281132151202222268
patients3482384001075193121141186236263299
were38093840010766111138182
those4019384001072878127162207
aged4254384001074192138189
18–654470384001074585133182226
years4723384001074085126154189
undergoing4939384001074998149195222271321341390441
gynecologic54073840010750923047398001074892134180200248298317357
surgery,3429398001073380107155199225268280
with3734398001076584112160
American39193980010752126170197216256298346
Society4289398001074291132150194222265
of4578398001074872
Anesthesiologists46753980010752101145178207256300334352400419468518536569598633
(ASA)5333398001072376119170194
physical3047412001074997135168186226267285
status3348412001073362102129176209
I-II.35734120010718466685100
Patients3690412001074484110129172219245280
with3986412001076483110158
significant416041200107335199147165188207247288335361
comorbidities,4537412001074086159207233283301350368395414457490505
prior505841200107507695142169
relevant524341200107266887130170211258285
drug3047426001075077127177
use,3252426001074882128143
ongoing3422426001074999150199219268319
chemotherapy,3768426001074190136211261289338384411454505545557
or4353426001074876
study-material4457426001073464113164205233310352380423451471512532
allergies501642600107426181126153203222267302
were53454260010766111138182
excluded.3047440001074483123142189238282332349
Furthermore,3417440001074288114145193237264338387414457471
patients3910440001074991118137181229256291
who42224400010765114162
experienced4406440001074383133178205224268316356399449
major48764400010774115134182209
bleeding5107440001074969113158208226274324
or5452440001074875
blood3047454001074968115163213
transfusion327545400107285495142174198246278296343391
during3682454001074894120139186234
surgery3932454001073379105152195221263
(>4211454001072374
40%4301454001074388154
of4471454001074770
MABL),45574540010769121166205228242
withdrawal4814454001076583110158206232273336376395
from522545400107235096169
the5410454001072774118
study,3047468001073463111160200212
and3282468001074189138
conversion3443468001074087135175218245279297345394
to3860468001072774
general3957468001074993141185212253272
anesthesia4252468001074189133167196244289322341381
during4656468001074996123142190239
surgery4918468001073481107155199226269
dropped5210468001074975122172222267317
out3047482001074896124
of3190482001074872
this328048200107287695127
study.3426482001073362110160200212
After3657482001075276107150176
providing3852482001074976123164183232251299348
informed421948200107186690137164239283333
consent,4570482001074187136169213261288304
the4893482001072876120
subjects5031482001073481131150193235265300
were53494820010765109135178
divided3047496001074968109128177221271
into333949600107196693140
two3499496001072896143
groups3663496001074975122170220253
(Group3937496001072478105152200250
1:4207496001074454
ibuprofen4281496001071969117166193240264308356
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paracetamol;4732496001074991117159200242270311385433453467
Group5219496001075784131179228
2:5468496001074459
ketorolac3047510001073881109156183230249290330
+33975100010754
paracetamol).3470510001075092118160200243271312385434454478491
After3187524001075274105146172
informed337452400107186587134160232275324
consent3713524001074085132164207254280
was40085240010764104137
obtained4160524001074796122162180227270318
and4494524001074087135
the4644524001072774117
inclusion4777524001071865104122168200217264311
criteria510452400107396583110152177195235
were53545240010764106132173
met,30475380010773117144160
patients3223538001074990116135178225251286
were35255380010764107133175
randomly3716538001072667114163211284302342
assigned4074538001074073106123172219262312
to4402538001072773
treatment449153800107285496136162235279326352
groups4859538001074975121168217250
using512553800107478098145193
block5334538001074969116157194
randomization3047552001072667113161208281299334375401419466513
with3576552001076482109156
a37485520010740
block3803552001074968115155192
size401055200107335086128
of4153552001074770
four,4239552001072369116141152
generated4407552001074891138181206247273314363
by4785552001074987
a48885520010740
computer-based4943552001074085157206253280321347370420460492535584
random3047566001072768116166214288
number3359566001074895169218263290
generator.3672566001074993142186212254281328355367
Group4063566001075683130178227
allocations431456600107416078127168209236255303352385
were47225660010765109135178
placed4924566001075069110150193243
in5190566001071967
sealed,5281566001073378118137181231246
opaque3047580001074898140189236280
envelopes3352580001074492132175194242293337371
and3748580001074189138
opened3911580001074898143192236286
by4222580001075089
a43365800010741
nurse4402580001074895122156200
who46275800010765114162
was48145800010765107140
not4979580001074897124
involved5128580001071967106154173214257308
in5461580001071866
data3047594001074990117158
collection3225594001074087106125169210240259307356
or3600594001074875
patient3695594001075091118137181229256
evaluation.3971594001074384126145192233260279327375391
Both3187608001074594121169
the3372608001072876120
anesthesiologist3508608001074189133166195243287320338386406453503522554583
responsible4107608001072770103152201249282300349369412
for453660800107237197
postoperative4650608001074998132160207256301327369396414455498
pain5165608001074990109156
management533860800107731141623047622001074191135209254303330
and3403622001074190140
the3569622001072877121
researcher3717622001072770104148189215255303348375
collecting4118622001074087107126170212243262310360
data4504622001074990118160
were46906220010765109136179
blinded489662200107507088137186231281
to5204622001072875
group5305622001074976124172222
allocation304763600107415978126167208235253301349
(double-blind).3413636001072470118166215235278307357377395443492516529
The3958636001074291135
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also460863600107416092140
unaware4765636001074795135199241267309
of5091636001074871
the5179636001072775119
medication531563600107731171671853047650001074082109128176224
they3291650001072876120160
received3471650001072669110153171212256306
(double-blind).3796650001072471119167217237281310360380398446496520533
All318766400107537291
patients3305664001075092119138182231258293
enrolled3625664001074492119166186205250300
in3952664001071967
the4045664001072877122
study4193664001073463112162202
underwent4422664001074896146191217286330378406
surgery4854664001073481108157201228271
under5152664001074896146191218
spinal53966640010734841033047678001074889108
anesthesia3180678001074189133167196244289322340381
in3586678001071967
the3678678001072876121
left382467800107196387118
lateral396867800107196087129156197216
position,4210678001074999132150178197245294309
with4545678001076584112160
insertion473167800107196699144170201220268317
at5073678001074168
the5166678001072877121
L3–L45312678001074186132174215
interspace304769200107196997142170205257300342387
using3461692001075084103153205
a36946920010742
25G3764692001074591148
Spinocan3940692001074394114164214258301351
needle.4319692001074995142194214260276
The4623692001074394140
anesthetic4791692001074292139174204254300330350392
regimen5211692001072772124144220266316
consisted3047706001074087135168187219248291341
of3411706001074872
0.5%3506706001074459104168
bupivacaine3697706001075098147167208249290331350398442
154162706001074481
mg42667060010774123
combined4412706001074087161211230278322372
with4807706001076584112161
fentanyl4991706001072367115142183231269289
255303706001074488
µg.5414706001074897113
Surgical3047720001074289115163182222264283
procedures3348720001074976123165207257305331374408
commenced3774720001074086160234278326367409459
once4251720001074897137180
the4449720001072876120
sensory4587720001073378126159207234277
block4882720001075069118159197
reached5097720001072669109150198242292
the5407720001072876120
T63047734001074282
dermatome.3145734001074993119193234261307381425440
After3602734001075275107149175
the3794734001072876120
surgery3930734001073481107155199225268
had4214734001074989138
been4369734001074994139187
completed4572734001074087160210229273301343393
and4981734001074189138
the5136734001072775119
patient5272734001075091118137180228255
had3047748001074888136
recovered3199748001072668109155194237263305354
from356974800107235096169
anesthesia3754748001074188131164193240283316334374
in4143748001071966
the4225748001072775118
Post-Anesthesia4359748001074590123151175227274317350379426470503520560
Care4935748001075091117159
Unit51107480010756102120148
(PACU),5274748001072367114162217240253
the3047762001072876120
assigned3190762001074074107125174222267317
analgesic3529762001074189130148198242276294334
regimen3885762001072770120138212256304
was42127620010765106139
administered4374762001074090163182230248281310353379422472
148687620010744
hour4935762001074896144171
postoperatively5128762001075099132161208258303330371304777600107284788131150190
according3254776001074081119166193241260307357
to3627776001072875
group3718776001074976123171220
allocation.395577600107415978126167209236254302351367
Group4339776001075683130178227
145837760010744
(ibuprofen-paracetamol)464377600107244392140190216263287331379407457499525567607650677719792841860884