495
PŮVODNÍ4021200011151111173233294355388
PRÁCE4435200011151111174230285
/4746200011132
ORIGINAL4804200011158118151213244306367421
PAPER5250200011151107163217278
Comparison10453200974690158204243270289321366412
of14733200974468
ibuprofen15583200971965110156183227251292338
and19123200973984130
paracetamol20593200974585112151188228255295362407427
combination25033200973679147193212257296323342387432
with29523200975979106151
ketorolac31193200973878105149176221241280316
and34523200973984130
paracetamol35993200974585111151187227255294362406426
in40423200971964
patients41233200974585112131172217243277
undergoing44163200974590136176203249293313358403
gynecologic48363200974584130171208251271316362381418
surgery52713200973176102148189216256
|5584190011126
247565419001114293133
/23588040010732
Anest24358040010752100145178207
intenziv266280400107196794136184221240282
Med.29638040010770115165181
2025;36(4):247-2523163804001074487129173186230273297339360375419459499522561605647
/38558040010731
ANESTEZIOLOGIE39528040010753112155200245290342362425467527586607650
A46248040010753
INTENZIVNÍ4698804001071978123168227276296345405426
MEDICÍNA51468040010770113173194247268327381
www.aimjournal.cz4258040010765133201214257275349367415463490539579598614654693
https://doi.org/10.36290/aim.2025.043420843009543679513916918321423644414300984692114455443009514578112515447074300984383102148191234277321347386408476496542585627671689733778820
Comparison4259100305150279482619741862943105111801323
of17999100305124215
ibuprofen20649100305752103514866017318219381080
and31959100305120268406
paracetamol36519100305136259379503616735834960116812941368
combination425117003051122404435786548029271021110012261369
with184511700305179262357502
ketorolac2398117003051392573554866017308059291042
and349111700305120268406
paracetamol394711700305136259379503616735834960116812941369
in4251430030574222
patients69814300305136259353432549692787895
undergoing16441430030514028642354065577790297811261249
gynecologic294314300305117243392509625753827952107311551268
surgery:426214300305103244363485601716844914
A42516900305159
review63516900305113233356439556739
of142516900305124215
pain169016900305137259341489
level,22301690030573190313430505573
coagulation285416900305112240363487631710835929100811341277
profile,418216900305136251380471555636752818
and42519500305120268406
interleukin-6881195003057522231743955462774388410281110125813301466
levels23971950030574190313431505613
Maarif42523400149102165228274305347
M.79623400149102134
K.1,9452340014974107104423500873910812340014931
Musba113623400149102172224296359
A.15192340014979112
M.164623400149101134
T.1,2,17952340014965891875235008739559619742340014931
Datu20292340014984147190260
M.231423400149101134
D.1,3,246323400149831112565235008739559626622340014931
Gaus27172340014982146216268
S.1,2,30092340014965963096235008739559631952340014931
Wirawan325023400149107140185247337399469
N.37442340014982114
S.1,3,38732340014965963961235008739559640582340014931
Adil41132340014979149182215
A.1,24352234001497911144552350087395596
1Department4252560071304532560012167118175223256292375425481513
of988256001215584
Anesthesiology,10932560012161116167206240295346385408463487542599647663
Intensive1777256001212479112161217256279327376
Care21742560012158107139189
and23842560012148104160
Pain25652560012154101124179
Management,27652560012181129185233288339422473529561582
Faculty3368256001214993138193216249299
of3688256001215584
Medicine,37942560012180131188211256279334384404
Hasanuddin42202560012165113152201257311368425448503
University,47442560012165120143191240273314337370420436
Makassar,4682690012180129176225264303352385401
Indonesia890269001212479136191247297337359407
2Department4252820071304562820012167118175223256292375425481513
of991282001215584
Anesthesiology,10962820012161116167206240295346385408463487542599647663
Intensive1780282001212479112161217256279327376
Care21772820012158107139189
and23872820012148104160
Pain25682820012154101124179
Management,27682820012181129185233288339422473529561582
Faculty3371282001214993138193216249299
of3691282001215584
Medicine,37972820012180131188211256279334384404
Dr.4223282001216699116
Wahidin43602820012185131186209266289344
Sudirohusodo47252820012149104161184216271327381420476533588
General4682950012165116172222255303327
Hospital,8162950012165121160217240273322346366
Makassar,12032950012181129176225264303352385401
Indonesia1625295001212479136191247297337360408
3Department4253080071304563080012167118175223256292375425481513
of991308001215584
Anesthesiology,10963080012161116167206240295346385408463487542599647663
Intensive1780308001212479112161217256279327376
Care21773080012158107139189
and23873080012148104160
Pain25683080012154101124179
Management,27683080012181129185233288339422473529561582
Faculty3371308001214993138193216249299
of3691308001215584
Medicine,37973080012180131188211256279334384404
Hasanuddin42233080012165113152201257311368425448503
University47473080012165120143191240273314337370420
Hospital,4683210012165121160216240273322345366
Makassar,8553210012180129176225264303352385401
Indonesia1277321001212479136191247297337360408
Background:4253600012358110156208265302360418476535560
Postoperative10133610012153107148182238296348382431465489538588
pain16293610012157107131187
management18453610012183132188237294346430482538572
in2445361001212380
gynecological25533610012156105162213260315340396454478524573598
surgery3179361001214095129185237270322
remains3529361001213384168217241298338
a38953610012148
significant3971361001214064121177201232259304354410444
challenge,44433610012145101150174198250306364415436
with4907361001217498133189
many51243610012183132189235
patients53883610012156106425375001213357108165198240
experiencing690375001215098156208242267318375421445501558
moderate12723750012184140198250283333366417
to1713375001213388
severe1826375001214091140190224274
pain21253750012157107131187
despite23373750012156107148205230264314
standard2676375001213974124180238287320378
analgesic30783750012148105154178235286327351397
interventions.3499375001212480113163197249300356390414470526566589
The41123750012150107159
risk429537500121335898145
of4465375001215585
complications,45743750012145100185242267291337387420444500557597619
such5218375001213995141197
as5439375001214889
bleeding425389001215782133185244268324381
and8293890012148105162
prolonged1015389001215790146171227284341392451
recovery,1489389001213383130185233283317368385
is1898389001212363
heightened19843890012156107132189245278329385437495
by25023890012157105
the2630389001213389140
use2794389001215595147
of2964389001215585
certain3072389001214595129166215240296
analgesics,33913890012148105154178235286327351397438460
emphasizing38753890012150134192249298338362406430486543
the4442389001213389140
need46063890012155107159217
for4846389001212985119
optimal49893890012154113147171255304328
pain53413890012156106130186
management4254030012183132189238295346431482539572
strategies.1018403001214075108158191241299323375415437
This14764030012150107131172
study1668403001214075131189237
compares19264030012145100184242292325376416
the2363403001213390141
efficacy2525403001215081114142187237283333
of2879403001215585
two29854030012133110166
multimodal31714030012184140164198222306362421470494
analgesic36864030012148104153178235286327351396
regimens-ibuprofen-paracetamol4103403001213384142166250301358398429455512569626660716746797854887946996103010791125117512091259134314001425
and4254170012148104162
ketorolac-paracetamol-on61041700121479713218722127630135039642348253256561566071074579587993596099310521108
pain,17414170012157107131187209
coagulation,19734170012145100150206262287336369393449506528
and25244170012148104162
interleukin-62709417001212480113163197222273330377403459492549
(IL-6)3281417001212852100124180207
levels.3511417001212475124174199239261
Methods:4254300012383136173231289349391416
A8674310012161
double-blind9544310012157113169227252303337396421445502559
randomized1539431001213382139196252337361405456514
trial207943100121336791140165
was22694310012174123164
conducted2459431001214499156213269315351402460
with2945431001217398132188
4031594310012152105
patients32904310012157107140164215272305347
undergoing36634310012155111169220254311367391448505
gynecological41944310012155104162213260314339396453477523573597
surgery.4817431001214095129185237271322339
Group5182431001216599155211269
154774310012151
received425445001213384130180205254304362
IV808445001212481
ibuprofen910445001212481138195229285315366423
(4001354445001212877131185
mg)15604450012183140168
+17494450012160
paracetamol18304450012156106140189235285319369453510535
(10002386445001212875123177231
mg);26384450012183141168188
Group2847445001216499154210268
231364450012151
received3208445001213384131181205254304363
IV3592445001212481
ketorolac3694445001214696131186220275300349395
(304110445001212979130
mg)42614450012184141169
+44504450012160
paracetamol45314450012157107140190235285320370454510535
(10005087445001212876123177231
mg).53394450012184141169188
Numeric4254590012166122206258292316362
Rating8124590012154103137161217274
Scale1112459001214995145169221
(NRS),1358459001212894149200228248
clotting1631459001214569125159195220276333
time1989459001213357141193
(CT),2207459001212985139171190
bleeding2423459001215782133185243268324381
time2829459001213357141193
(BT),3047459001212983134166186
and32584590012148104162
IL-6344545900121247396152
were36234590012173124158208
assessed3857459001214888128180220260312370
at4252459001214882
6,4359459001215273
24,44584590012151100122
and46054590012148104162
4847924590012152105
hours49234590012155111167201242
postoperatively.51914590012157113154189244302425473001215084133167191240290315364381
Results:4254860012357110153210237273317341
Pain7904870012153101126182
scores995487001213986140174225266
and12844870012148104162
CT14694870012158112
did1604487001215680138
not17654870012156112145
differ1934487001215680111144196229
significantly2187487001213963120176200231258304353410443467516
between27264870012157109143220271323379
the3128487001213390141
groups.3292487001215690145202259300322
The36374870012150107159
ketorolac3819487001214797131186220276301350395
group4238487001215689145201259
showed4520487001214096152226276334
a48784870012148
significant4949487001214064120177201231258304354410443
increase5416487001212379425501001214477128176216267
in711501001212379
BT8095010012154104
at933501001214881
2410335010012151100
and11525010012148104161
4813325010012151104
hours14565010012155110166199240
(p1715501001212986
<18205010012159
0.05),1899501001215171123174201220
while21395010012173129153177227
the2386501001213388139
ibuprofen2545501001212380135192226281311361417
group2982501001215588143199256
had32575010012155104161
significantly3437501001214063119175199229255301350405438462510
lower3966501001212479152202236
IL-6422150100121247295150
levels4391501001212374122172196236
at4646501001214881
2447465010012151100
hours48655010012156111167200241
(p5125501001212885
<52305010012159
0.05).5308501001215172124175202221
Conclusion:4255140012358114171216243300342368424482505
Both9495150012154109142197
regimens1166515001213282139162245296352391
were15765150012173122156206
equally18015150012149107161210233257305
effective2125515001214979112163209244268316365
for2509515001212984118
pain26465150012156105129184
control.2849515001214498154186219274298320
However,31885150012164120193242290339372389
ketorolac-paracetamol3596515001214796129183217271296344389415473522555604649698732781863919943
significantly4558515001213963119174198227254299348403436459507
prolonged5084515001215690144169224280336386444
bleeding425529001215782133185244268324381
time,831529001213357141193214
while10695290012174131155179230
ibuprofen-paracetamol1324529001212481138195229285315366423456515565598648694744778828912968993
was23425290012174123163
more25305290012184140174224
effective2779529001215081115166213249273322372
in3176529001212480
reducing3281529001213283141197243267323380
inflammation3686529001212480110137186270354404437461517574
by42855290012157104
lowering4414529001212379153204238262318375
IL-6481452900121247296152
levels.4991529001212475124174199239261
These52775290012150107158199250
differences425543001215681111145196230281337383433474
should922543001214096152208233290
be12355430012157109
considered,1368543001214499156196220277329362413472493
particularly18845430012157107141178202247303327376410435483
in2390543001212480
patients24935430012157107140164216272306347
at2863543001214982
risk296854300121335898145
of3136543001215585
bleeding.3245543001215782133185243267324381403
Key4255590012358108158
words:6035590012375131167225267290
pain9155600012157106129184
management,11205600012184132187235291341425475531563584
coagulation1726560001214498147203257281329361384439495
profile,2242560001215790145174200223274294
interleukin-6,2557560001212378111160193217267322369394449481536557
ibuprofen,3135560001212480136192225280309359415436
ketorolac,3592560001214796129183216271295343388409
paracetamol,40225600012157106138187231280314363446501525546
gynecological45895600012156103160210256310334389445469513562586
surgery.5196560001213994126182232265315332
Srovnání4255840016671132202267346413492535
kombinace9845840016676144253325365444511571635
ibuprofenu16435840016640113188260322391439501577651
a23185840016666
paracetamolu24085840016674140204270330393446513625692731806
s32385840016656
ketorolakem33185840016676138191260321391430496574637747
a40895840016665
paracetamolem41785840016674140204270330394446513625693732794903
u4255980016676
pacientek5255980016675140200241304380431496571
podstupujících11205980016674143218275327403475551596635696737797874
gynekologickou20185980016664131211273348416455522586629690766833909
operaci:29515980016668141205266332392433469
přehled34445980016675137202278320382456
úrovně39245980016677140209274354417
bolesti,43655980016673142181243300353394431
koagulačního4256120016676144209275353394461521599642721788
profilu12376120016675136205253298340414
a16756120016666
hladin17656120016677118185258301380
interleukinu-621696120016641120170235296334396472549592671745783856
Úvod:4256320012367118173232255
Léčba699633001214797143199248
pooperační9666330012157113168226277310358403458481
bolesti14666330012157113137187227261284
u17696330012155
gynekologických18436330012156104160211258312336391448471516562612656711
výkonů2574633001214898146200255310
i29036330012124
nadále29466330012155103160208231282
představuje3247633001215790140197236270319365421445495
závažný3761633001214393140188231287332
problém,4112633001215790145202226276360381
jelikož451263300121247599122168222264
mnoho47956330012184139194250305
pacientek51196330012157106151174224280312361408
pociťuje4256470012156110155177209262285334
středně775647001213972103152207261310
silnou110264700121396183137190244
až1363647001214789
silnou146864700121396184137191245
bolest,17296470012156110133182221253274
a20196470012148
to2083647001213385
i21856470012123
navzdory22246470012155102147190245299331380
standardním2620647001213972119173228275306361415437518
analgetickým31556470012147101148170225274306328372417466548
postupům.37196470012156111149181235290344425445
Riziko4181647001215376117140185237
komplikací,4435647001214698180235258280325373417439458
jako4910647001212470116168
je5095647001212372
krvácení5184647001214679129176219267321343
a4256610012148
prodloužená495661001215790144202225280335378428484532
doba10496610012156111168217
rekonvalescence,1288661001213282129183239285334357407447492541597642691711
se2020661001214090
zvyšuje2132661001214394144184238262312
při2466661001215790113
užití2601661001215598121154177
některých28006610012155106153189238271321365420
analgetik,32426610012148103151175231281315338384408
což3671661001214599141
zdůrazňuje38336610012143100154187235279334389412463
nutnost43176610012156110144199254293327
optimálních46666610012155112145168251299323378401445500
strategií5188661001214074106155187236293316339
pro425675001215790145
zvládání599675001214394118166223272327351
bolesti.9786750012157113138188228262285306
Tato1313675001215091124179
studie1520675001214074129186210260
srovnává1809675001213972127174231279326375
účinnost22126750012155101124179235290329364
dvou26046750012157105160215
multimodálních28486750012184139162195219302358415464487543566611666
analgetických35436750012148104152176232283316340385431482526581
režimů4153675001213283126150233288
–44706750012150
ibuprofen‑paracetamol4548675001212481136193227281311361417450508557590639684733767816900955979
a4256890012148
ketorolak‑paracetamol494689001214796130184217271295343390418476525558606651700733782865920945
–14606890012150
na15316890012155103
bolest,16566890012157112136187226260281
koagulaci19586890012147101150206260284332377399
a23796890012148
hladiny2448689001215679127184207262307
interleukinu-62777689001212378111160193217267322369394449503535591
(IL-6).338968900121285198121176202220
Metody:4257020012383135171227286336360
Byla8087030012154102126174
provedena1005703001215689144191240297348403451
dvojitě14797030012156105159182206239288
zaslepená1789703001214393132155206263314369417
studie2229703001213973128185208258
se2510703001213990
4026227030012151104
pacientkami,27487030012157106151174224280312359408491514535
které3305703001214783132165215
podstoupily35427030012157113170210244298353410433456504
gynekologickou40687030012156104160211258312336391448471515562616671
operaci.47617030012155112163196245290313333
Skupině5117703001214995151208231286337
154767030012151
byl4257170012157103127
podán5807170012157113170218273
intravenózně881717001212379111143192239288343398440496546
ibuprofen1455717001212380135192225279308359414
(4001897717001212876129182
mg)21007170012183139166
+22947170012159
paracetamol23817170012157105138186231280314362446501525
(10002933717001212975122175228
mg);31827170012183139166184
skupina3394717001214086142198222277325
237477170012151
obdržela38267170012155112169202246296320368
intravenózně4222717001212378110143191238287343398440495546
ketorolak4795717001214796129184216271295343390
(305212717001212978129
mg)53617170012183140166
CORRESPONDING485757009746100144188229269312367421475495549601
AUTHOR:1103757009749100141194250294312
1432757009518
Článek329375700984768110156198240
přijat35507570098467697119160189
redakcí:375575700982971119160201237258277
16.40497570095397489
6.415675700953953
2025;422775700953978115154166
Článek441075700984768110156198240
přijat46677570098467697119160189
k4872757009841
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